Human HGF Recombinant Protein – Cat# MBS965929

Hepatocyte Growth Factor (HGF) Human Recombinant Protein

Name: HGF Recombinant Protein; Hepatocyte Growth Factor; Human; MyBioSource
Brand: MyBioSource
SKU: MBS965929
Price: 900 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS965929

Hepatocyte growth factor regulates cell growth, cell motility, and morphogenesis by activating a tyrosine kinase signaling cascade after binding to the proto-oncogenic c-Met receptor. Hepatocyte growth factor is secreted by mesenchymal cells and acts as a… More details

$900 / 0.02 mg (E-Coli) +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Hepatocyte growth factor (HGF), Recombinant Protein

Full Product Name

Recombinant Human Hepatocyte growth factor (HGF)

Product Gene Name

HGF recombinant protein

Sequence

VVNGIPTRTN IGWMVSLRYR NKHICGGSLI KESWVLTARQ CFPSRDLKDY EAWLGIHDVH GRGDEKCKQV LNVSQLVYGP EGSDLVLMKL ARPAVLDDFV STIDLPNYGC TIPEKTSCSV YGWGYTGLIN YDGLLRVAHL YIMGNEKCSQ HHRGKVTLNE SEICAGAEKI GSGPCEGDYG GPLVCEQHKM RMVLGVIVPG RGCAIPNRPG IFVRVAYYAK WIHKIILTYK VPQS

Host

E Coli or Yeast or Baculovirus or Mammalian Cell

Form/Format

Lyophilized or liquid (Format to be determined during the manufacturing process)

Purity/Purification

Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)

Preparation and Storage

Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Molecular Weight

24,116 Da

Sequence Positions

495-728aa; Partial

Tag Information

This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.

Sterility

Sterile filter available upon request.

Endotoxin

Low endotoxin available upon request.

OMIM

142409

3D Structure

ModBase 3D Structure for P14210

Species

Human

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of HGF recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for HGF purchase

MBS965929 is a recombinant protein targeting HGF. Also known as Recombinant Human Hepatocyte growth factor (HGF). Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for HGF. It may not necessarily be applicable to this product.

NCBI GI #

33859835

NCBI GeneID

3082

NCBI Accession #

NP_000592.3

UniProt Primary Accession #

P14210

UniProt Secondary Accession #

Q02935; Q13494; Q14519; Q3KRB2; Q8TCE2; Q9BYL9; Q9BYM0; Q9UDU6; A1L3U6

UniProt Related Accession #

P14210

GenBank Nucleotide #

NM_000601.5

NCBI Official Full Name

hepatocyte growth factor isoform 1 preproprotein

NCBI Official Synonym Full Names

hepatocyte growth factor

NCBI Official Symbol

HGF

NCBI Official Synonym Symbols

SF; HGFB; HPTA; F-TCF; DFNB39

UniProt Protein Name

Hepatocyte growth factor

UniProt Synonym Protein Names

Hepatopoietin-A; Scatter factor; SF

Protein Family

Hepatocyte growth factor

UniProt Gene Name

HGF

UniProt Synonym Gene Names

HPTA; SF

NCBI Protein Information

hepatocyte growth factor

NCBI Summary for HGF

This gene encodes a protein that binds to the hepatocyte growth factor receptor to regulate cell growth, cell motility and morphogenesis in numerous cell and tissue types. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate alpha and beta chains, which form the mature heterodimer. This protein is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. This protein also plays a role in angiogenesis, tumorogenesis, and tissue regeneration. Although the encoded protein is a member of the peptidase S1 family of serine proteases, it lacks peptidase activity. Mutations in this gene are associated with nonsyndromic hearing loss. [provided by RefSeq, Nov 2015]

UniProt Comments for HGF

Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization.

Research Articles on HGF

1. The results suggested that HGF may inhibit TEMT by inhibiting AngII through the JAK2/STAT3 signaling pathway in HK2 cells and HGF may prevent apoptosis induced by AngII. The present study provides a basis for understanding the mechanisms involved in the inhibition of TEMT by HGF, which requires further investigation

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with HGF recombinant protein

Reference Product	PubMed Publications
MET recombinant protein	>2381 publications with HGF and MET
ST14 recombinant protein	>8 publications with HGF and ST14
SDC1 recombinant protein	>8 publications with HGF and SDC1
NRP1 recombinant protein	>6 publications with HGF and NRP1
LCN2 recombinant protein	>3 publications with HGF and LCN2
HGFAC recombinant protein	>2 publications with HGF and HGFAC
FN1 recombinant protein	>2 publications with HGF and FN1
PLAU recombinant protein	>1 publications with HGF and PLAU

Pathways associated with HGF recombinant protein

Products by Pathway	Pathway Diagram
Arf6 Signaling Events Pathway antibodies	Arf6 Signaling Events Pathway Diagram
Cytokine Signaling In Immune System Pathway antibodies	Cytokine Signaling In Immune System Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Direct P53 Effectors Pathway antibodies	Direct P53 Effectors Pathway Diagram
FGF Signaling Pathway antibodies	FGF Signaling Pathway Diagram
Focal Adhesion Pathway antibodies	Focal Adhesion Pathway Diagram
Focal Adhesion Pathway antibodies	Focal Adhesion Pathway Diagram
Focal Adhesion Pathway antibodies	Focal Adhesion Pathway Diagram
Hemostasis Pathway antibodies	Hemostasis Pathway Diagram

Diseases associated with HGF recombinant protein

Disease Name	Pubmed Publications
Liver Diseases Antibodies	>762 publications with HGF and Liver Diseases
Disease Models, Animal Antibodies	>626 publications with HGF and Disease Models, Animal
Vascular Diseases Antibodies	>604 publications with HGF and Vascular Diseases
Necrosis Antibodies	>458 publications with HGF and Necrosis
Fibrosis Antibodies	>444 publications with HGF and Fibrosis
Liver Neoplasms Antibodies	>435 publications with HGF and Liver Neoplasms
Neoplasm Invasiveness Antibodies	>428 publications with HGF and Neoplasm Invasiveness
Inflammation Antibodies	>423 publications with HGF and Inflammation
Neoplasms, Experimental Antibodies	>307 publications with HGF and Neoplasms, Experimental
Kidney Diseases Antibodies	>300 publications with HGF and Kidney Diseases

Organs/Tissues associated with HGF recombinant protein

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>1823 publications with HGF and Blood
Liver Antibodies	>1686 publications with HGF and Liver
Vascular Antibodies	>1239 publications with HGF and Vascular
Bone Antibodies	>757 publications with HGF and Bone
Kidney Antibodies	>748 publications with HGF and Kidney
Lung Antibodies	>679 publications with HGF and Lung
Muscle Antibodies	>610 publications with HGF and Muscle
Bone Marrow Antibodies	>529 publications with HGF and Bone Marrow
Embryonic Tissue Antibodies	>377 publications with HGF and Embryonic Tissue
Brain Antibodies	>353 publications with HGF and Brain