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Neuroligin-3 (NLGN3) Rat Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1436139

This gene encodes a member of a family of neuronal cell surface proteins. Members of this family may act as splice site-specific ligands for beta-neurexins and may be involved in the formation and remodeling of central nervous system synapses. Mutations in… More details

$2005 / 0.5 mg (E-Coli) +2 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Neuroligin-3 (Nlgn3), Recombinant Protein
Full Product Name
Recombinant Rat Neuroligin-3 (Nlgn3), partial
Product Gene Name
Nlgn3 recombinant protein
Product Synonym Gene Name
Nlgn3
Sequence
QAP APTVNTHFGK LRGARVPLPS EILGPVDQYL GVPYAAPPIG EKRFLPPEPP PSWSGIRNAT HFPPVCPQNI HTAVPEVMLP VWFTANLDIV ATYIQEPNED CLYLNVYVPT EDVKRISKEC ARKPNKKICR KGGSGAKKQG EDLADNDGDE DEDIRDSGAK PVMVYIHGGS YMEGTGNMID GSVLASYGNV IVITLNYRVG VLGFLSTGDQ AAKGNYGLLD QIQALRWVSE NIAFFGGDPR RITVFGSGIG ASCVSLLTLS HHSEGLFQRA IIQSGSALSS WAVNYQPVKY TSLLADKVGC NVLDTVDMVD CLRQKSAKEL VEQDIQPARY HVAFGPVIDG DVIPDDPEIL MEQGEFLNYD IMLGVNQGEG LKFVEGVVDP EDGVSGTDFD YSVSNFVDNL YGYPEGKDTL RETIKFMYTD WADRDNPETR RKTLVALFTD HQWVEPSVVT ADLHARYGSP TYFYAFYHHC QSLMKPAWSD AAHGDEVPYV FGVPMVGPTD LFPCNFSKND VMLSAVVMTY WTNFAKTGDP NKPVPQDTKF IHTKANRFEE VAWSKYNPRD QLYLHIGLKP RVRDHYRATK VAFWKHLVPH LYNLHDMFHY TSTTTKVPPP DTTHSSHITR RPNGKTWSTK RPAISPAYSN ENAPGSWNGD QDAGPLLVEN PRDYSTELS
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
91,563 Da
Sequence Positions
38-709
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
3D Structure
ModBase 3D Structure for Q62889
Species
Rat
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of Nlgn3 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Nlgn3 purchase

MBS1436139 is a recombinant protein targeting Nlgn3. Also known as Recombinant Rat Neuroligin-3 (Nlgn3), partial. Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for Nlgn3. It may not necessarily be applicable to this product.

NCBI GI #
145966694
NCBI GeneID
171297
NCBI Accession #
NP_599163.2
UniProt Primary Accession #
Q62889
UniProt Related Accession #
Q62889
GenBank Nucleotide #
NM_134336.2
NCBI Official Full Name
neuroligin-3
NCBI Official Synonym Full Names
neuroligin 3
NCBI Official Symbol
Nlgn3
UniProt Protein Name
Neuroligin-3
UniProt Synonym Protein Names
Gliotactin homolog
Protein Family
Neuroligin
UniProt Gene Name
Nlgn3
NCBI Protein Information
neuroligin-3

NCBI Summary for Nlgn3

neuronal cell surface protein that binds neurexins [RGD, Feb 2006]

UniProt Comments for Nlgn3

Cell surface protein involved in cell-cell-interactions via its interactions with neurexin family members. Plays a role in synapse function and synaptic signal transmission, and probably mediates its effects by recruiting and clustering other synaptic proteins. May promote the initial formation of synapses, but is not essential for this. May also play a role in glia-glia or glia-neuron interactions in the developing peripheral nervous system.
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Research Articles on Nlgn3

1. e found that NLGN3 function at inhibitory synapses in rat CA1 depends on the presence of NLGN2 and identified a domain in the extracellular region that accounted for this functional difference between NLGN2 and 3 specifically at inhibitory synapses.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with Nlgn3 recombinant protein

 Reference Product  PubMed Publications
 Nrxn1 recombinant protein  >7 publications with Nlgn3 and Nrxn1
 Nrxn3 recombinant protein  >3 publications with Nlgn3 and Nrxn3
 Nrxn2 recombinant protein  >1 publications with Nlgn3 and Nrxn2

Pathways associated with Nlgn3 recombinant protein

 Products by Pathway  Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram

Diseases associated with Nlgn3 recombinant protein

 Disease Name  Pubmed Publications
 Autistic Disorder Antibodies  >18 publications with Nlgn3 and Autistic Disorder
 Drug Toxicity Antibodies  >2 publications with Nlgn3 and Drug Toxicity
 Brain Diseases Antibodies  >2 publications with Nlgn3 and Brain Diseases
 Prenatal Exposure Delayed Effects Antibodies  >2 publications with Nlgn3 and Prenatal Exposure Delayed Effects
 Ataxia Antibodies  >1 publications with Nlgn3 and Ataxia
 AUTISM, SUSCEPTIBILITY TO, X-LINKED 1 Antibodies  >1 publications with Nlgn3 and AUTISM, SUSCEPTIBILITY TO, X-LINKED 1

Organs/Tissues associated with Nlgn3 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >10 publications with Nlgn3 and Brain
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