Mouse mIL 17 A/F Recombinant Protein – Cat# MBS143623

Interleukin-17 A/F Heterodimer (mIL 17 A/F) Mouse Recombinant Protein

Name: mIL 17 A/F Recombinant Protein; Mouse; MyBioSource
Brand: MyBioSource
SKU: MBS143623
Price: 250 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS143623

Description: Interleukin-17 A/F Mouse Recombinant produced in E Coli is a heterodimeric, non-glycosylated polypeptide comprised of IL17A monomeric subunit & and IL17F monomeric subunit containing a total of 266 amino acids and having a total molecular mass of… More details

$250 / 0.002 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Interleukin-17 A/F Heterodimer (mIL 17 A/F), Recombinant Protein

Full Product Name

Recombinant Mouse Interleukin-17 A/F Heterodimer

Product Gene Name

mIL 17 A/F recombinant protein

Product Synonym Names

IL 17 A/F Mouse; Interleukin-17 A/F Heterodimer Mouse Recombinant; IL17A/F; IL17 A/F; IL-17A/F; IL-17 A/F; IL17AF; IL-17 AF; Interleukin-17 A/F; Interleukin-17 AF

Sequence

RKNPKAGVPA LQKAGNCPPL EDNTVRVDIR IFNQNQGISV PREFQNRSSS PWDYNITRDP HRFPSEIAEA QCRHSGCINA QGQEDSTMNS VAIQQEILVL RREPQGCSNS FRLEKMLLKV GCTCVKPIVH QAAAAIIPQS SACPNTEAKD FLQNVKVNLK VFNSLGAKVS SRRPSDYLNR STSPWTLHRN EDPDRYPSVI WEAQCRHQRC VNAEGKLDHH MNSVLIQQEI LVLKREPESC PFTFRVEKML VGVGCTCVAS IVRQAA

Host

E Coli

Form/Format

Lyophilized from a concentrated (1mg/ml) solution containing no additives.
Sterile Filtered White lyophilized (freeze-dried) powder.

Purity/Purification

Greater than 97.0% as determined by SDS-PAGE.

Preparation and Storage

Lyophilized Mouse IL17 A/F although stable at room temperature for 3 weeks, should be stored desiccated below -18 degree C. Upon reconstitution Mouse IL17 A/F should be stored at 4 degree C between 2-7 days and for future use below -18 degree C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.

Molecular Weight

17,504 Da

OMIM

603149

Solubility

It is recommended to reconstitute the lyophilized Mouse IL17 A/F in sterile 18M Omega -cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions.

Product Categories/Family for mIL 17 A/F recombinant protein

Cytokines and Growth Factors; Cytokines; Interleukin

Other Notes

Small volumes of mIL 17 A/F recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for mIL 17 A/F purchase

MBS143623 is a recombinant protein targeting mIL 17 A/F. Also known as Recombinant Mouse Interleukin-17 A/F Heterodimer. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for mIL 17 A/F. It may not necessarily be applicable to this product.

NCBI GI #

299832923

NCBI GeneID

3605

NCBI Accession #

ADJ56412.1

UniProt Secondary Accession #

Q5T2P0

UniProt Related Accession #

Q16552

NCBI Official Full Name

interleukin 17A, partial

NCBI Official Synonym Full Names

interleukin 17A

NCBI Official Symbol

IL17A

NCBI Official Synonym Symbols

IL17; CTLA8; IL-17; IL-17A

UniProt Protein Name

Interleukin-17A

UniProt Synonym Protein Names

Cytotoxic T-lymphocyte-associated antigen 8; CTLA-8

UniProt Gene Name

IL17A

UniProt Synonym Gene Names

CTLA8; IL17; IL-17; IL-17A; CTLA-8

UniProt Entry Name

IL17_HUMAN

NCBI Protein Information

interleukin-17A; CTLA-8; cytotoxic T-lymphocyte-associated antigen 8; cytotoxic T-lymphocyte-associated protein 8; interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8)

NCBI Summary for mIL 17 A/F

The protein encoded by this gene is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. [provided by RefSeq, Jul 2008]

UniProt Comments for mIL 17 A/F

IL17A: Induces stromal cells to produce proinflammatory and hematopoietic cytokines. Enhances the surface expression of ICAM1/intracellular adhesion molecule 1 in fibroblasts. Belongs to the IL-17 family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 6p12

Cellular Component: extracellular space; external side of plasma membrane

Molecular Function: cytokine activity

Biological Process: cell death; cell-cell signaling; positive regulation of interleukin-23 production; apoptosis; positive regulation of osteoclast differentiation; protein amino acid glycosylation; immune response; positive regulation of transcription from RNA polymerase II promoter; inflammatory response

Research Articles on mIL 17 A/F

1. Serum IL-17 and IL-23 levels demonstrate no association with type 1 and type 2 diabetes, but, in line with previous studies, TGF-beta levels were lower in type 1 diabetic patients

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with mIL 17 A/F recombinant protein

Reference Product	PubMed Publications
FOXP3 recombinant protein	>680 publications with mIL 17 A/F and FOXP3
STAT3 recombinant protein	>289 publications with mIL 17 A/F and STAT3
TGFB1 recombinant protein	>150 publications with mIL 17 A/F and TGFB1
IL6 recombinant protein	>120 publications with mIL 17 A/F and IL6
IL17RA recombinant protein	>117 publications with mIL 17 A/F and IL17RA
STAT1 recombinant protein	>89 publications with mIL 17 A/F and STAT1
IL23A recombinant protein	>71 publications with mIL 17 A/F and IL23A
IL17RC recombinant protein	>26 publications with mIL 17 A/F and IL17RC
NFKB1 recombinant protein	>3 publications with mIL 17 A/F and NFKB1

Pathways associated with mIL 17 A/F recombinant protein

Products by Pathway	Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
IL17 Signaling Pathway antibodies	IL17 Signaling Pathway Diagram
IL23-mediated Signaling Events Pathway antibodies	IL23-mediated Signaling Events Pathway Diagram
IL27-mediated Signaling Events Pathway antibodies	IL27-mediated Signaling Events Pathway Diagram
Inflammatory Bowel Disease (IBD) Pathway antibodies	Inflammatory Bowel Disease (IBD) Pathway Diagram
Inflammatory Bowel Disease (IBD) Pathway antibodies	Inflammatory Bowel Disease (IBD) Pathway Diagram
Rheumatoid Arthritis Pathway antibodies	Rheumatoid Arthritis Pathway Diagram
Rheumatoid Arthritis Pathway antibodies	Rheumatoid Arthritis Pathway Diagram
TCR Signaling Pathway antibodies	TCR Signaling Pathway Diagram

Diseases associated with mIL 17 A/F recombinant protein

Disease Name	Pubmed Publications
Inflammation Antibodies	>2525 publications with mIL 17 A/F and Inflammation
Autoimmune Diseases Antibodies	>1898 publications with mIL 17 A/F and Autoimmune Diseases
Disease Models, Animal Antibodies	>1364 publications with mIL 17 A/F and Disease Models, Animal
Necrosis Antibodies	>1051 publications with mIL 17 A/F and Necrosis
Respiratory Tract Diseases Antibodies	>744 publications with mIL 17 A/F and Respiratory Tract Diseases
Lung Diseases Antibodies	>654 publications with mIL 17 A/F and Lung Diseases
Central Nervous System Diseases Antibodies	>555 publications with mIL 17 A/F and Central Nervous System Diseases
Hypersensitivity Antibodies	>522 publications with mIL 17 A/F and Hypersensitivity
Liver Diseases Antibodies	>202 publications with mIL 17 A/F and Liver Diseases
Fibrosis Antibodies	>182 publications with mIL 17 A/F and Fibrosis

Organs/Tissues associated with mIL 17 A/F recombinant protein

Organ/Tissue Name	Pubmed Publications
Mixed Antibodies	>107 publications with mIL 17 A/F and Mixed