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Dedicator of Cytokinesis Protein 8 (DOCK8) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1436565

MBS1436565 is a recombinant protein targeting DOCK8. Also known as Recombinant Human Dedicator of cytokinesis protein 8 (DOCK8) , partial. Host: E Coli or Yeast or Baculovirus or Mammalian Cell. More details

$385 / 0.02 mg (E-Coli) +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Dedicator of cytokinesis protein 8 (DOCK8), Recombinant Protein
Full Product Name
Recombinant Human Dedicator of cytokinesis protein 8 (DOCK8) , partial
Product Gene Name
DOCK8 recombinant protein
Product Synonym Gene Name
DOCK8
Sequence
RNLLYVYPQR LNFVNKLASA RNITIKIQFM CGEDASNAMP VIFGKSSGPE FLQEVYTAVT YHNKSPDFYE EVKIKLPAKL TVNHHLLFTF YHISCQQKQG ASVETLLGYS WLPILLNERL QTGSYCLPVA LEKLPPNYSM HSAEKVPLQN PPIKWAEGHK GVFNIEVQAV
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
21.3 kDa
Sequence Positions
560-729aa; Partial
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
OMIM
243700
3D Structure
ModBase 3D Structure for Q8NF50
Species
Human
Production Note
Special Offer: The Yeast host-expressed protein is manufactured from a stock plasmid containing the protein gene. Yeasthost-expressed protein is stocked in different unit sizes ranging from as small as 10 ug to as large as 1 mg. Bulk inventory is also available. The Yeast host-expressed protein has been ordered over and over again by researchers and has stood the test of time as both a robust protein and important target for the research community. It is part of our new program to make our most popular protein targets and corresponding hosts available in expanded unit sizes and with a quick processing time. Select Yeast host-expressed protein for the fastest delivery among all hosts. Please contact our technical support team or email to support@mybiosource.com for more details.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

SDS-Page of DOCK8 recombinant protein

Human DOCK8 Recombinant Protein – Cat# MBS1436565

Other Notes

Small volumes of DOCK8 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for DOCK8. It may not necessarily be applicable to this product.

NCBI GI #
299473744
NCBI GeneID
81704
NCBI Accession #
NP_001177387.1
UniProt Primary Accession #
Q8NF50
UniProt Secondary Accession #
Q3MV16; Q5JPJ1; Q8TEP1; Q8WUY2; Q9BYJ5; Q9H1Q2; A2A350; A2BDF2; A4FU78; B7ZLP0; E9PH09
UniProt Related Accession #
Q8NF50
GenBank Nucleotide #
NM_001190458.1
NCBI Official Full Name
dedicator of cytokinesis protein 8 isoform 2
NCBI Official Synonym Full Names
dedicator of cytokinesis 8
NCBI Official Symbol
DOCK8
NCBI Official Synonym Symbols
MRD2; ZIR8; HEL-205
UniProt Protein Name
Dedicator of cytokinesis protein 8
Protein Family
Dedicator of cytokinesis protein
UniProt Gene Name
DOCK8
NCBI Protein Information
dedicator of cytokinesis protein 8

NCBI Summary for DOCK8

This gene encodes a member of the DOCK180 family of guanine nucleotide exchange factors. Guanine nucleotide exchange factors interact with Rho GTPases and are components of intracellular signaling networks. Mutations in this gene result in the autosomal recessive form of the hyper-IgE syndrome. Alternatively spliced transcript variants encoding different isoforms have been described.[provided by RefSeq, Jun 2010]
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UniProt Comments for DOCK8

Guanine nucleotide exchange factor (GEF) which specifically activates small GTPase CDC42 by exchanging bound GDP for free GTP (PubMed:28028151, PubMed:22461490). During immune responses, required for interstitial dendritic cell (DC) migration by locally activating CDC42 at the leading edge membrane of DC (). Required for CD4+ T-cell migration in response to chemokine stimulation by promoting CDC42 activation at T cell leading edge membrane (PubMed:28028151). Is involved in NK cell cytotoxicity by controlling polarization of microtubule-organizing center (MTOC), and possibly regulating CCDC88B-mediated lytic granule transport to MTOC during cell killing (PubMed:25762780).
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Research Articles on DOCK8

1. Recent advances in the understanding of DOCK8 function are summarized, paying particular attention to an emerging role as a signaling intermediate to promote immune responses to diverse external stimuli. [Review]

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with DOCK8 recombinant protein

 Reference Product  PubMed Publications
 CDC42 recombinant protein  >3 publications with DOCK8 and CDC42
 RAC1 recombinant protein  >2 publications with DOCK8 and RAC1

Pathways associated with DOCK8 recombinant protein

 Products by Pathway  Pathway Diagram
 Factors Involved In Megakaryocyte Development And Platelet Production Pathway antibodies  Factors Involved In Megakaryocyte Development And Platelet Production Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram

Diseases associated with DOCK8 recombinant protein

 Disease Name  Pubmed Publications
 Job Syndrome Antibodies  >29 publications with DOCK8 and Job Syndrome
 Nervous System Diseases Antibodies  >8 publications with DOCK8 and Nervous System Diseases
 Disease Models, Animal Antibodies  >6 publications with DOCK8 and Disease Models, Animal
 Brain Diseases Antibodies  >4 publications with DOCK8 and Brain Diseases
 Inflammation Antibodies  >4 publications with DOCK8 and Inflammation
 Congenital Abnormalities Antibodies  >3 publications with DOCK8 and Congenital Abnormalities
 Liver Diseases Antibodies  >2 publications with DOCK8 and Liver Diseases
 Neurobehavioral Manifestations Antibodies  >2 publications with DOCK8 and Neurobehavioral Manifestations
 Abnormalities, Multiple Antibodies  >2 publications with DOCK8 and Abnormalities, Multiple
 Intellectual Disability Antibodies  >2 publications with DOCK8 and Intellectual Disability

Organs/Tissues associated with DOCK8 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >22 publications with DOCK8 and Blood
 Skin Antibodies  >6 publications with DOCK8 and Skin
 Bone Marrow Antibodies  >4 publications with DOCK8 and Bone Marrow
 Lymph Node Antibodies  >4 publications with DOCK8 and Lymph Node
 Connective Tissue Antibodies  >3 publications with DOCK8 and Connective Tissue
 Lung Antibodies  >3 publications with DOCK8 and Lung
 Lymph Antibodies  >2 publications with DOCK8 and Lymph
 Nerve Antibodies  >1 publications with DOCK8 and Nerve
 Thymus Antibodies  >1 publications with DOCK8 and Thymus
 Brain Antibodies  >1 publications with DOCK8 and Brain
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