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Serine/Threonine-Protein Kinase 3 (stk3) Danio Rerio Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1436636

MBS1436636 is a recombinant protein targeting stk3. Also known as Recombinant Danio rerio Serine/threonine-protein kinase 3 (stk3). Host: E Coli or Yeast or Baculovirus or Mammalian Cell. More details

$1290 / 0.02 mg (E-Coli) +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Serine/threonine-protein kinase 3 (stk3), Recombinant Protein
Full Product Name
Recombinant Danio rerio Serine/threonine-protein kinase 3 (stk3)
Product Gene Name
stk3 recombinant protein
Product Synonym Gene Name
stk3
Sequence
MEHSVPKNKL KKLSEDSLTK QPEEVFDVLE KLGEGSYGSV FKAIHKESGQ VVAIKQVPVE SDLQEIIKEI SIMQQCDSPY VVKYYGSYFK NTDLWIVMEY CGAGSVSDII RLRNKTLTED EIATVLKSTL KGLEYLHFMR KIHRDIKAGN ILLNTEGHAK LADFGVAGQL TDTMAKRNTV IGTPFWMAPE VIQEIGYNCV ADIWSLGITS IEMAEGKPPY ADIHPMRAIF MIPTNPPPTF RKPEHWSDDF TDFVKKCLVK NPEQRATATQ LLQHPFIVGA KPVSILRDLI TEAMDMKAKR QQEQQRELEE DDENSEEEVE VDSHTMVKSG SESAGTMRAT GTMSDGAQTM IEHGSTMLES NLGTMVINSD DEEEEEDLGS MRRNPTSQQI QRPSFMDYFD KQDSNKAQEG FNHNQQDPCL ISKTAFPDNW KVPQDGDFDF LKNLDFEELQ MRLTALDPMM EREIEELRQR YTAKRQPILD AMDAKKRRQQ NF
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
56,081 Da
Sequence Positions
1-492, Full length protein
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
3D Structure
ModBase 3D Structure for Q7ZUQ3
Species
Zebrafish
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of stk3 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for stk3. It may not necessarily be applicable to this product.

NCBI GI #
41054445
NCBI GeneID
324125
NCBI Accession #
NP_955966.1
UniProt Primary Accession #
Q7ZUQ3
UniProt Related Accession #
Q7ZUQ3
GenBank Nucleotide #
NM_199672.1
NCBI Official Full Name
serine/threonine-protein kinase 3
NCBI Official Synonym Full Names
serine/threonine kinase 3 (STE20 homolog, yeast)
NCBI Official Symbol
stk3
NCBI Official Synonym Symbols
zgc:55383; wu:fc19e11
UniProt Protein Name
Serine/threonine-protein kinase 3
Protein Family
Serine/threonine-protein kinase
UniProt Gene Name
stk3
UniProt Synonym Gene Names
MST2/N; MST2/C
NCBI Protein Information
serine/threonine-protein kinase 3

UniProt Comments for stk3

Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein stk3/mst2 and stk4/mst1, in complex with its regulatory protein sav1, phosphorylates and activates lats1/2 in complex with its regulatory protein mob1, which in turn phosphorylates and inactivates yap1 oncoprotein and wwtr1/taz. Phosphorylation of yap1 by lats2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration.
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with stk3 recombinant protein

 Products by Pathway  Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By Hippo Pathway antibodies  Signaling By Hippo Pathway Diagram

Diseases associated with stk3 recombinant protein

 Disease Name  Pubmed Publications
 Breast Neoplasms Antibodies  >5 publications with stk3 and Breast Neoplasms
 Liver Neoplasms Antibodies  >4 publications with stk3 and Liver Neoplasms
 Adenocarcinoma Antibodies  >4 publications with stk3 and Adenocarcinoma
 Carcinoma, Hepatocellular Antibodies  >3 publications with stk3 and Carcinoma, Hepatocellular
 Liver Diseases Antibodies  >3 publications with stk3 and Liver Diseases
 Disease Models, Animal Antibodies  >3 publications with stk3 and Disease Models, Animal
 Hypertrophy Antibodies  >2 publications with stk3 and Hypertrophy
 Liver Neoplasms, Experimental Antibodies  >2 publications with stk3 and Liver Neoplasms, Experimental
 Necrosis Antibodies  >2 publications with stk3 and Necrosis
 Ovarian Diseases Antibodies  >1 publications with stk3 and Ovarian Diseases

Organs/Tissues associated with stk3 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >2 publications with stk3 and Bone
 Eye Antibodies  >1 publications with stk3 and Eye
 Muscle Antibodies  >1 publications with stk3 and Muscle
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