Human MAT2B Recombinant Protein – Cat# MBS143722

Methionine Adenosyltransferase II, Beta (MAT2B) Human Recombinant Protein

Name: MAT2B Recombinant Protein; Human; MyBioSource
Brand: MyBioSource
SKU: MBS143722
Price: 250 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS143722

Description: Recombinant Human MAT2B produced in E Coli is a single, non-glycosylated polypeptide chain containing 323 amino acids (1-323 a.a) and having a molecular mass of 36.4 kDa. MAT2B is is purified by conventional chromatography… More details

$250 / 0.005 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Methionine Adenosyltransferase II, Beta (MAT2B), Recombinant Protein

Full Product Name

Recombinant Human Methionine Adenosyltransferase II, Beta

Product Gene Name

MAT2B recombinant protein

Product Synonym Names

MAT2B Human; Methionine Adenosyltransferase II Beta Human Recombinant; MAT2-beta; MAT-2B; MAT2-B; DTDP-4-keto-6-deoxy-D-glucose 4-reductase; MAT-II; MATIIbeta; MAT II beta; Methionine adenosyltransferase 2 subunit beta; Methionine adenosyltransferase II beta; MGC12237; MSTP045; Nbla02999; SDR23E1; TGR; UNQ2435/PRO4995; MAT2B

Sequence

MPEMPEDMEQ EEVNIPNRRV LVTGATGLLG RAVHKEFQQN NWHAVGCGFR RARPKFEQVN LLDSNAVHHI IHDFQPHVIV HCAAERRPDV VENQPDAASQ LNVDASGNLA KEAAAVGAFL IYISSDYVFD GTNPPYREED IPAPLNLYGK TKLDGEKAVL ENNLGAAVLR IPILYGEVEK LEESAVTVMF DKVQFSNKSA NMDHWQQRFP THVKDVATVC RQLAEKRMLD PSIKGTFHWS GNEQMTKYEM ACAIADAFNL PSSHLRPITD SPVLGAQRPR NTQLDCSKLE TLGIGQRTPF RIGIKESLWP FLIDKRWRQT VFH

Host

E Coli

Form/Format

The MAT2B protein solution contains 20mM Tris-HCl, pH-8, 1mM DTT, 1mM EDTA and 10% Glycerol.
Sterile filtered colorless solution.

Purity/Purification

Greater than 90.0% as determined by SDS-PAGE.

Preparation and Storage

Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.

Molecular Weight

9,488 Da

OMIM

605527

3D Structure

ModBase 3D Structure for Q9NZL9

Product Categories/Family for MAT2B recombinant protein

Enzymes; Transferase

Other Notes

Small volumes of MAT2B recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MAT2B purchase

MBS143722 is a recombinant protein targeting MAT2B. Also known as Recombinant Human Methionine Adenosyltransferase II, Beta. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for MAT2B. It may not necessarily be applicable to this product.

NCBI GI #

11034825

NCBI GeneID

27430

NCBI Accession #

NP_037415.1

UniProt Primary Accession #

Q9NZL9

UniProt Secondary Accession #

Q1WAI7; Q27J92; Q3LIE8; Q567T7; Q6NYC7; Q9BS89; Q9H3E1; Q9UJ54; B2R5Y6

UniProt Related Accession #

Q9NZL9

GenBank Nucleotide #

NM_013283.4

NCBI Official Full Name

methionine adenosyltransferase 2 subunit beta isoform 1

NCBI Official Synonym Full Names

methionine adenosyltransferase II, beta

NCBI Official Symbol

MAT2B

NCBI Official Synonym Symbols

TGR; MAT-II; SDR23E1; MATIIbeta; Nbla02999

UniProt Protein Name

Methionine adenosyltransferase 2 subunit beta

UniProt Synonym Protein Names

Methionine adenosyltransferase II beta; MAT II beta; Putative dTDP-4-keto-6-deoxy-D-glucose 4-reductase

Protein Family

Methionine adenosyltransferase

UniProt Gene Name

MAT2B

UniProt Synonym Gene Names

TGR; MAT II beta

UniProt Entry Name

MAT2B_HUMAN

NCBI Protein Information

methionine adenosyltransferase 2 subunit beta; MAT II beta; beta regulatory subunit of methionine adenosyltransferase; dTDP-4-keto-6-deoxy-D-glucose 4-reductase; putative dTDP-4-keto-6-deoxy-D-glucose 4-reductase; putative protein product of Nbla02999; short chain dehydrogenase/reductase family 23E, member 1

NCBI Summary for MAT2B

The protein encoded by this gene belongs to the methionine adenosyltransferase (MAT) family. MAT catalyzes the biosynthesis of S-adenosylmethionine from methionine and ATP. This protein is the regulatory beta subunit of MAT. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2012]

UniProt Comments for MAT2B

MAT2B: Non-catalytic regulatory subunit of S-adenosylmethionine synthetase 2 (MAT2A), an enzyme that catalyzes the formation of S- adenosylmethionine from methionine and ATP. Regulates the activity of S-adenosylmethionine synthetase 2 by changing its kinetic properties, rendering the enzyme more susceptible to S- adenosylmethionine inhibition. Belongs to the dTDP-4-dehydrorhamnose reductase family. MAT2B subfamily. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Amino Acid Metabolism - cysteine and methionine; Other Amino Acids Metabolism - selenoamino acid; Transferase

Chromosomal Location of Human Ortholog: 5q34

Cellular Component: methionine adenosyltransferase complex; mitochondrion; intracellular; cytosol; nucleus

Molecular Function: methionine adenosyltransferase regulator activity; enzyme binding

Biological Process: methylation; regulation of catalytic activity; xenobiotic metabolic process; S-adenosylmethionine biosynthetic process; one-carbon compound metabolic process

Research Articles on MAT2B

1. resveratrol induces HuR, SIRT1, and MAT2B expression; the last may represent a compensatory response against apoptosis and growth inhibition.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with MAT2B recombinant protein

Products by Pathway	Pathway Diagram
Biological Oxidations Pathway antibodies	Biological Oxidations Pathway Diagram
Biosynthesis Of Amino Acids Pathway antibodies	Biosynthesis Of Amino Acids Pathway Diagram
Biosynthesis Of Amino Acids Pathway antibodies	Biosynthesis Of Amino Acids Pathway Diagram
Cysteine And Methionine Metabolism Pathway antibodies	Cysteine And Methionine Metabolism Pathway Diagram
Cysteine And Methionine Metabolism Pathway antibodies	Cysteine And Methionine Metabolism Pathway Diagram
Defective AHCY Causes Hypermethioninemia With S-adenosylhomocysteine Hydrolase Deficiency (HMAHCHD) Pathway antibodies	Defective AHCY Causes Hypermethioninemia With S-adenosylhomocysteine Hydrolase Deficiency (HMAHCHD) Pathway Diagram
Defective GCLC Causes Hemolytic Anemia Due To Gamma-glutamylcysteine Synthetase Deficiency (HAGGSD) Pathway antibodies	Defective GCLC Causes Hemolytic Anemia Due To Gamma-glutamylcysteine Synthetase Deficiency (HAGGSD) Pathway Diagram
Defective GGT1 Causes Glutathionuria (GLUTH) Pathway antibodies	Defective GGT1 Causes Glutathionuria (GLUTH) Pathway Diagram
Defective GSS Causes Glutathione Synthetase Deficiency (GSS Deficiency) Pathway antibodies	Defective GSS Causes Glutathione Synthetase Deficiency (GSS Deficiency) Pathway Diagram
Defective MAT1A Causes Methionine Adenosyltransferase Deficiency (MATD) Pathway antibodies	Defective MAT1A Causes Methionine Adenosyltransferase Deficiency (MATD) Pathway Diagram

Diseases associated with MAT2B recombinant protein

Disease Name	Pubmed Publications
Liver Diseases Antibodies	>7 publications with MAT2B and Liver Diseases
Liver Neoplasms Antibodies	>6 publications with MAT2B and Liver Neoplasms
Carcinoma, Hepatocellular Antibodies	>5 publications with MAT2B and Carcinoma, Hepatocellular
Growth Disorders Antibodies	>1 publications with MAT2B and Growth Disorders
Cell Transformation, Neoplastic Antibodies	>1 publications with MAT2B and Cell Transformation, Neoplastic
Neoplasm Metastasis Antibodies	>1 publications with MAT2B and Neoplasm Metastasis
Fatty Liver Antibodies	>1 publications with MAT2B and Fatty Liver

Organs/Tissues associated with MAT2B recombinant protein

Organ/Tissue Name	Pubmed Publications
Liver Antibodies	>11 publications with MAT2B and Liver
Muscle Antibodies	>1 publications with MAT2B and Muscle
Blood Antibodies	>1 publications with MAT2B and Blood
Lung Antibodies	>1 publications with MAT2B and Lung