Human FABP4 Recombinant Protein – Cat# MBS143781

Fatty Acid Binding Protein-4 (FABP4) Human Recombinant Protein

Name: FABP4 Recombinant Protein; Fatty Acid Binding Protein-4; Human; MyBioSource
Brand: MyBioSource
SKU: MBS143781
Price: 250 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS143781

Description: FABP4 Human Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 132 amino acids and having a molecular mass of 18 kDa. FABP4 is fused to His tag at N-terminus and purified by standard chromatography… More details

$250 / 0.002 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Fatty Acid Binding Protein-4 (FABP4), Recombinant Protein

Full Product Name

Recombinant Human Fatty Acid Binding Protein-4, His Tag

Product Gene Name

FABP4 recombinant protein

Product Synonym Names

FABP4 Human, His; Fatty Acid Binding Protein 4 Human Recombinant, His Tag; Fatty acid-binding protein adipocyte; AFABP; Fatty acid-binding protein 4; Adipocyte lipid-binding protein; ALBP; A-FABP; FABP4; FABP4 His

Host

E Coli

Form/Format

FABP4 His-Tag is supplied in 20mM Tris HCL pH=8, 0.5mM DTT and 50% glycerol.
Sterile Filtered colorless liquid formulation.

Purity/Purification

Greater than 95% as determined by SDS-PAGE.

Preparation and Storage

Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time.Please avoid freeze thaw cycles.

Molecular Weight

14,719 Da

OMIM

600434

3D Structure

ModBase 3D Structure for P15090

Product Categories/Family for FABP4 recombinant protein

Recombinant & Natural Proteins; Recombinant Proteins; FABP

Other Notes

Small volumes of FABP4 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for FABP4 purchase

MBS143781 is a recombinant protein targeting FABP4. Also known as Recombinant Human Fatty Acid Binding Protein-4, His Tag. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for FABP4. It may not necessarily be applicable to this product.

NCBI GI #

4557579

NCBI GeneID

2167

NCBI Accession #

NP_001433.1

UniProt Primary Accession #

P15090

UniProt Secondary Accession #

Q6IBA1

UniProt Related Accession #

P15090

GenBank Nucleotide #

NM_001442.2

NCBI Official Full Name

fatty acid-binding protein, adipocyte

NCBI Official Synonym Full Names

fatty acid binding protein 4, adipocyte

NCBI Official Symbol

FABP4

NCBI Official Synonym Symbols

aP2; ALBP; AFABP; A-FABP; HEL-S-104

UniProt Protein Name

Fatty acid-binding protein, adipocyte

UniProt Synonym Protein Names

Adipocyte lipid-binding protein; ALBP; Adipocyte-type fatty acid-binding protein; A-FABP; AFABP; Fatty acid-binding protein 4

Protein Family

Fatty acid-binding protein

UniProt Gene Name

FABP4

UniProt Synonym Gene Names

ALBP; A-FABP; AFABP

UniProt Entry Name

FABP4_HUMAN

NCBI Protein Information

fatty acid-binding protein, adipocyte; adipocyte lipid-binding protein; adipocyte-type fatty acid-binding protein; epididymis secretory protein Li 104; fatty acid-binding protein 4

NCBI Summary for FABP4

FABP4 encodes the fatty acid binding protein found in adipocytes. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. It is thought that FABPs roles include fatty acid uptake, transport, and metabolism. [provided by RefSeq, Jul 2008]

UniProt Comments for FABP4

FABP4: a lipid transport protein that is the predominant fatty acid binding protein found in adipocytes. Also expressed in macrophages. Binds both long chain fatty acids and retinoic acid. Delivers long-chain fatty acids and retinoic acid to their cognate receptors in the nucleus. Homodimer. Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior. Interacts with PPARG. Monomer. FABP4 knockout mice fed a high-fat and high-calorie diet become obese but develop neither insulin resistance nor diabetes, suggesting that this protein might be a link between obesity and insulin resistance and diabetes. Mice deficient in both FABP4 and ApoE show protection against atherosclerosis when compared with mice deficient only in ApoE. Mice carrying a FABP4 genetic variant exhibit both reduced FABP4 expression and a reduced potential for developing type 2 diabetes and coronary heart disease. A related study in humans indicated a similar pattern, suggesting that FABP4 may be a potential therapeutic target in the treatment of these disorders. Belongs to the calycin superfamily,fatty-acid binding protein (FABP) family.

Protein type: Lipid-binding

Chromosomal Location of Human Ortholog: 8q21

Cellular Component: cytoplasm; lipid particle; nucleus

Molecular Function: transporter activity; fatty acid binding

Biological Process: cholesterol homeostasis; transport; white fat cell differentiation; triacylglycerol catabolic process; brown fat cell differentiation; negative regulation of protein kinase activity; cytokine production; negative regulation of transcription, DNA-dependent; positive regulation of inflammatory response

Research Articles on FABP4

1. A strong association was found between adipocyte fatty acid binding protein and FGF 21 levels in metabolic syndrome individuals.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with FABP4 recombinant protein

Reference Product	PubMed Publications
LPL recombinant protein	>69 publications with FABP4 and LPL
CD36 recombinant protein	>41 publications with FABP4 and CD36
ADIPOQ recombinant protein	>29 publications with FABP4 and ADIPOQ
WNT10B recombinant protein	>10 publications with FABP4 and WNT10B
ANGPTL4 recombinant protein	>9 publications with FABP4 and ANGPTL4
PPARA recombinant protein	>8 publications with FABP4 and PPARA
LIPE recombinant protein	>5 publications with FABP4 and LIPE
PLIN1 recombinant protein	>4 publications with FABP4 and PLIN1

Pathways associated with FABP4 recombinant protein

Products by Pathway	Pathway Diagram
Developmental Biology Pathway antibodies	Developmental Biology Pathway Diagram
Hormone-sensitive Lipase (HSL)-mediated Triacylglycerol Hydrolysis Pathway antibodies	Hormone-sensitive Lipase (HSL)-mediated Triacylglycerol Hydrolysis Pathway Diagram
Lipid Digestion, Mobilization, And Transport Pathway antibodies	Lipid Digestion, Mobilization, And Transport Pathway Diagram
Metabolism Pathway antibodies	Metabolism Pathway Diagram
Metabolism Of Lipids And Lipoproteins Pathway antibodies	Metabolism Of Lipids And Lipoproteins Pathway Diagram
PPAR Signaling Pathway antibodies	PPAR Signaling Pathway Diagram
PPAR Signaling Pathway antibodies	PPAR Signaling Pathway Diagram
Transcriptional Regulation Of White Adipocyte Differentiation Pathway antibodies	Transcriptional Regulation Of White Adipocyte Differentiation Pathway Diagram

Diseases associated with FABP4 recombinant protein

Disease Name	Pubmed Publications
Insulin Resistance Antibodies	>148 publications with FABP4 and Insulin Resistance
Inflammation Antibodies	>99 publications with FABP4 and Inflammation
Cardiovascular Diseases Antibodies	>82 publications with FABP4 and Cardiovascular Diseases
Fatty Liver Antibodies	>74 publications with FABP4 and Fatty Liver
Necrosis Antibodies	>43 publications with FABP4 and Necrosis
Heart Diseases Antibodies	>32 publications with FABP4 and Heart Diseases
Disease Models, Animal Antibodies	>27 publications with FABP4 and Disease Models, Animal
Liver Diseases Antibodies	>27 publications with FABP4 and Liver Diseases
Weight Loss Antibodies	>22 publications with FABP4 and Weight Loss
Hypertension Antibodies	>21 publications with FABP4 and Hypertension

Organs/Tissues associated with FABP4 recombinant protein

Organ/Tissue Name	Pubmed Publications
Adipose Tissue Antibodies	>254 publications with FABP4 and Adipose Tissue
Blood Antibodies	>207 publications with FABP4 and Blood
Connective Tissue Antibodies	>170 publications with FABP4 and Connective Tissue
Muscle Antibodies	>87 publications with FABP4 and Muscle
Bone Antibodies	>76 publications with FABP4 and Bone
Vascular Antibodies	>69 publications with FABP4 and Vascular
Heart Antibodies	>51 publications with FABP4 and Heart
Brain Antibodies	>25 publications with FABP4 and Brain
Lung Antibodies	>18 publications with FABP4 and Lung
Kidney Antibodies	>16 publications with FABP4 and Kidney