Rat rCNTF Active Protein – Cat# MBS143807

Ciliary Neurotrophic Factor (rCNTF) Rat Active Protein

Name: rCNTF Active Protein; Ciliary Neurotrophic Factor; Rat; MyBioSource
Brand: MyBioSource
SKU: MBS143807
Price: 250 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS143807

Description: CNTF Recombinant Rat produced in E Coli is a single, non-glycosylated polypeptide chain containing 200 amino acids and having a molecular mass of 22834 Dalton. The CNTF is purified by proprietary chromatographic techniques.Introduction: CNTF is a… More details

$250 / 0.005 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Ciliary Neurotrophic Factor (rCNTF), Active Protein

Full Product Name

Recombinant Rat Ciliary Neurotrophic Factor

Product Gene Name

rCNTF active protein

Product Synonym Names

CNTF Rat; Ciliary Neurotrophic Factor Rat Recombinant; HCNTF; CNTF; Ciliary Neurotrophic Factor

Sequence

AFAEQTPLTL HRRDLSSRSI WLARKIRSDL TALMESYVKH QGLNKNINLD SVDGVPVAST DRWSEMTEAE RLQENLQAYR TFQGMLTKLL EDQRVHFTPT EGDFHQAIHT LMLQVSAFAY QLEELMVLLE QKIPENEADG MPATVGDGGL FEKKLWGLKV LQELSQWTVR SIHDLRVISS HQMGISALES HYGAKDKQM

Host

E Coli

Form/Format

Lyophilized from a concentrated (1mg/ml) solution in water containing 0.025% NaHCO3.
Sterile Filtered White lyophilized (freeze-dried) powder.

Purity/Purification

Greater than 99.0% as determined by: (a) Analysis by Gel Filtration. (b) Analysis by SDS-PAGE.

Preparation and Storage

Lyophilized CNTF although stable at room temperature for 3 weeks, should be stored desiccated below -18 degree C. Upon reconstitution CNTF should be stored at 4 degree C between 2-7 days and for future use below -18 degree C.Please prevent freeze-thaw cycles.

Molecular Weight

22,854 Da

3D Structure

ModBase 3D Structure for P20294

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Solubility

It is recommended to reconstitute the lyophilized CNTF in sterile water or 0.4% NaHCO3 adjusted to pH 8-9, not less than 100 ug/ml, which can then be further diluted to other aqueous solutions, preferably in presence of carrier protein.

Biological Activity

Fully biologically active by its ability to phosphorylate STAT3 in several cells lines.

Product Categories/Family for rCNTF active protein

Cytokines and Growth Factors; Neurotrophins; Ciliary-Neurotrophic Factor

Other Notes

Small volumes of rCNTF active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for rCNTF purchase

MBS143807 is an active protein targeting rCNTF. Also known as Recombinant Rat Ciliary Neurotrophic Factor. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for rCNTF. It may not necessarily be applicable to this product.

NCBI GI #

6978675

NCBI GeneID

25707

NCBI Accession #

NP_037298.1

UniProt Primary Accession #

P20294

UniProt Related Accession #

P20294

GenBank Nucleotide #

NM_013166.1

NCBI Official Full Name

ciliary neurotrophic factor

NCBI Official Synonym Full Names

ciliary neurotrophic factor

NCBI Official Symbol

Cntf

UniProt Protein Name

Ciliary neurotrophic factor

Protein Family

Ciliary neurotrophic factor

UniProt Gene Name

Cntf

UniProt Synonym Gene Names

CNTF

UniProt Entry Name

CNTF_RAT

NCBI Protein Information

ciliary neurotrophic factor; ciliary neurotropic factor

NCBI Summary for rCNTF

a cytokine involved in neuronal degeneration and adipocyte gene expression [RGD, Feb 2006]

UniProt Comments for rCNTF

CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy.

Research Articles on rCNTF

1. Compared to the rats in the control group, the rats in the HF group had the expression levels of 12 genes with significant changes, Agrp, Ghrl, and Nr3c1, Apoa4, Cntf, Ghr, IL-1beta, Ins1, Lepr,Sort, Adcyap1r1 and Adrb1.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with rCNTF active protein

Reference Product	PubMed Publications
Stat3 active protein	>212 publications with rCNTF and Stat3
Lifr active protein	>129 publications with rCNTF and Lifr
Gfap active protein	>118 publications with rCNTF and Gfap
Il6st active protein	>112 publications with rCNTF and Il6st
Socs3 active protein	>31 publications with rCNTF and Socs3
Pomc active protein	>16 publications with rCNTF and Pomc
Gap43 active protein	>8 publications with rCNTF and Gap43
Notch1 active protein	>7 publications with rCNTF and Notch1

Pathways associated with rCNTF active protein

Products by Pathway	Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Delta-Notch Signaling Pathway antibodies	Delta-Notch Signaling Pathway Diagram
Jak-STAT Signaling Pathway antibodies	Jak-STAT Signaling Pathway Diagram
Jak-STAT Signaling Pathway antibodies	Jak-STAT Signaling Pathway Diagram

Diseases associated with rCNTF active protein

Disease Name	Pubmed Publications
Nervous System Diseases Antibodies	>611 publications with rCNTF and Nervous System Diseases
Brain Diseases Antibodies	>302 publications with rCNTF and Brain Diseases
Disease Models, Animal Antibodies	>247 publications with rCNTF and Disease Models, Animal
Nerve Degeneration Antibodies	>196 publications with rCNTF and Nerve Degeneration
Inflammation Antibodies	>112 publications with rCNTF and Inflammation
Necrosis Antibodies	>91 publications with rCNTF and Necrosis
Peripheral Nervous System Diseases Antibodies	>81 publications with rCNTF and Peripheral Nervous System Diseases
Weight Loss Antibodies	>73 publications with rCNTF and Weight Loss
Atrophy Antibodies	>69 publications with rCNTF and Atrophy
Movement Disorders Antibodies	>59 publications with rCNTF and Movement Disorders

Organs/Tissues associated with rCNTF active protein

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>1302 publications with rCNTF and Brain
Dorsal Root Ganglion Antibodies	>168 publications with rCNTF and Dorsal Root Ganglion
Kidney Antibodies	>40 publications with rCNTF and Kidney
Inner Ear Antibodies	>32 publications with rCNTF and Inner Ear