Mouse mMCP-2 Active Protein – Cat# MBS143826

Monocyte Chemotactic Protein-2 (mMCP-2) Mouse Active Protein

Name: mMCP-2 Active Protein; Monocyte Chemotactic Protein-2; Mouse; MyBioSource
Brand: MyBioSource
SKU: MBS143826
Price: 250 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS143826

Description: Monocyte Chemotactic Protein-2 Mouse Recombinant produced in E Coli is a non-glycosylated, Polypeptide chain containing 74 amino acids and having a molecular mass of 8507 Dalton. The MCP-2 is purified by proprietary chromatographic… More details

$250 / 0.002 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Monocyte Chemotactic Protein-2 (mMCP-2), Active Protein

Full Product Name

Recombinant Mouse Monocyte Chemotactic Protein-2 (CCL8)

Product Gene Name

mMCP-2 active protein

Product Synonym Names

MCP 2 Mouse; Monocyte Chemotactic Protein-2 Mouse Recombinant (CCL8); Small inducible cytokine A8; CCL8; Monocyte chemotactic protein 2; MCP-2; Monocyte chemoattractant protein 2; HC14; chemokine (C-C motif) ligand 8; MCP2; SCYA8; SCYA10; AB023418; 1810063B20Rik

Sequence

GPDKAPVTCC FHVLKLKIPL RVLKSYERIN NIQCPMEAVV FQTKQGMSLC VDPTQKWVSE YMEILDQKSQ ILQP

Host

E Coli

Form/Format

Lyophilized from a 0.2 um filtered concentrated (1.0mg/ml) solution in 20mM PB, pH 7.4, 150mM NaCl.
Sterile Filtered White lyophilized (freeze-dried) powder.

Purity/Purification

Greater than 97.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.

Preparation and Storage

Lyophilized MCP-2 although stable at room temperature for 3 weeks, should be stored desiccated below -18 degree C. Upon reconstitution CCL8 should be stored at 4 degree C between 2-7 days and for future use below -18 degree C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.

Molecular Weight

11,017 Da

3D Structure

ModBase 3D Structure for Q9Z121

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Solubility

It is recommended to reconstitute the lyophilized CCL8in sterile 18M Omega -cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions.

Biological Activity

Determined by its ability to chemoattract human peripheral blood monocytes using a concentration range of 10-100ng/ml corresponding to a Specific Activity of 10,000-100,000IU/mg.

Product Categories/Family for mMCP-2 active protein

Chemokines; MCP

Other Notes

Small volumes of mMCP-2 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for mMCP-2 purchase

MBS143826 is an active protein targeting mMCP-2. Also known as Recombinant Mouse Monocyte Chemotactic Protein-2 (CCL8). Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for mMCP-2. It may not necessarily be applicable to this product.

NCBI GI #

10946818

NCBI GeneID

20307

NCBI Accession #

NP_067418.1

UniProt Primary Accession #

Q9Z121

UniProt Related Accession #

Q9Z121

GenBank Nucleotide #

NM_021443.3

NCBI Official Full Name

C-C motif chemokine 8

NCBI Official Synonym Full Names

chemokine (C-C motif) ligand 8

NCBI Official Symbol

Ccl8

NCBI Official Synonym Symbols

HC14; Mcp2; MCP-2; Scya8; AB023418; 1810063B20Rik

UniProt Protein Name

C-C motif chemokine 8

UniProt Synonym Protein Names

Monocyte chemoattractant protein 2; Monocyte chemotactic protein 2; MCP-2; Small-inducible cytokine A8

Protein Family

C-C motif chemokine

UniProt Gene Name

Ccl8

UniProt Synonym Gene Names

Mcp2; Scya8; MCP-2

UniProt Entry Name

CCL8_MOUSE

NCBI Protein Information

C-C motif chemokine 8; monocyte chemoattractant protein 2; monocyte chemoattractant protein-2; monocyte chemotactic protein 2; small inducible cytokine A8; small-inducible cytokine A8

UniProt Comments for mMCP-2

CCL8: Chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils. May play a role in neoplasia and inflammatory host responses. This protein can bind heparin. The processed form MCP-2(6-76) does not show monocyte chemotactic activity, but inhibits the chemotactic effect most predominantly of CCL7, and also of CCL2 and CCL5 and CCL8. Belongs to the intercrine beta (chemokine CC) family.

Protein type: Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide; Chemokine

Cellular Component: extracellular space; extracellular region

Molecular Function: heparin binding; chemokine activity; cytokine activity

Biological Process: immune response; chemotaxis; inflammatory response; positive regulation of myoblast differentiation

Research Articles on mMCP-2

1. these data reveal an important role for BLIMP1 in modulating host defenses by suppressing expression of the chemokine CCL8.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with mMCP-2 active protein

Products by Pathway	Pathway Diagram
Chemokine Signaling Pathway antibodies	Chemokine Signaling Pathway Diagram
Chemokine Signaling Pathway antibodies	Chemokine Signaling Pathway Diagram
Chemokine Signaling Pathway antibodies	Chemokine Signaling Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram

Diseases associated with mMCP-2 active protein

Disease Name	Pubmed Publications
Inflammation Antibodies	>112 publications with mMCP-2 and Inflammation
Necrosis Antibodies	>38 publications with mMCP-2 and Necrosis
Lung Diseases Antibodies	>34 publications with mMCP-2 and Lung Diseases
Hypersensitivity Antibodies	>27 publications with mMCP-2 and Hypersensitivity
Disease Models, Animal Antibodies	>25 publications with mMCP-2 and Disease Models, Animal
Respiratory Hypersensitivity Antibodies	>13 publications with mMCP-2 and Respiratory Hypersensitivity
Atherosclerosis Antibodies	>9 publications with mMCP-2 and Atherosclerosis
Lymphoma Antibodies	>8 publications with mMCP-2 and Lymphoma
Lung Injury Antibodies	>7 publications with mMCP-2 and Lung Injury
Arthritis, Rheumatoid Antibodies	>7 publications with mMCP-2 and Arthritis, Rheumatoid

Organs/Tissues associated with mMCP-2 active protein

Organ/Tissue Name	Pubmed Publications
Bone Antibodies	>27 publications with mMCP-2 and Bone
Bone Marrow Antibodies	>21 publications with mMCP-2 and Bone Marrow
Spleen Antibodies	>5 publications with mMCP-2 and Spleen
Thymus Antibodies	>3 publications with mMCP-2 and Thymus
Pancreas Antibodies	>3 publications with mMCP-2 and Pancreas
Prostate Antibodies	>3 publications with mMCP-2 and Prostate
Testis Antibodies	>2 publications with mMCP-2 and Testis
Thyroid Antibodies	>1 publications with mMCP-2 and Thyroid