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2-Oxoglutarate Dehydrogenase (OGDH) Mouse Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1438331

The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and… More details

$455 / 0.02 mg (E-Coli) +1 FREE 8GB USB
Product Documentation
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
2-oxoglutarate dehydrogenase (Ogdh), Recombinant Protein
Full Product Name
Recombinant Mouse 2-oxoglutarate dehydrogenase, mitochondrial
Product Gene Name
Ogdh recombinant protein
Product Synonym Names
2-oxoglutarate dehydrogenase complex component E1; OGDC-E1; Alpha-ketoglutarate dehydrogenase
Sequence
VDKRTCIPMN HLWPNQAPYT VCNSSLSEYG VLGFELGFAM ASPNALVLWE AQFGDFNNMA QCIIDQFICP GQAKWVRQNG IVLLLPHGME GMGPEHSSAR PERFLQMCND DPDVLPDLQE ENFDINQLYD CNWIVVNCST PGNFFHVLRR QILLPFRKPL IVFTPKSLLR HPEARTSFDE MLPGTHFQRV IPENGPAAQD PHKVKRLLFC TGKVYYDLTR ERKARNMEEE VAITRIEQLS PFPFDLLLKE AQKYPNAELA WCQEEHKNQG YYDYVKPRLR TTIDRAKPVW YAGRDPAAAP ATGNKKTHLT ELQRFLDTAF DLDAFKKFS
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
Molecular Weight
53.9 kDa
Sequence Positions
695-1023aa; Partial
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
3D Structure
ModBase 3D Structure for Q60597
Species
Mus musculus (Mouse)
Production Note
Special Offer: The E Coli host-expressed protein is manufactured from a stock plasmid containing the protein gene. E Colihost-expressed protein is stocked in different unit sizes ranging from as small as 10 ug to as large as 1 mg. Bulk inventory is also available. The E Coli host-expressed protein has been ordered over and over again by researchers and has stood the test of time as both a robust protein and important target for the research community. It is part of our new program to make our most popular protein targets and corresponding hosts available in expanded unit sizes and with a quick processing time. Select E Coli host-expressed protein for the fastest delivery among all hosts. Please contact our technical support team or email to support@mybiosource.com for more details.

Product Categories/Family for Ogdh recombinant protein

Metabolism
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

SDS-PAGE of Ogdh recombinant protein

Mouse OGDH Recombinant Protein – Cat# MBS1438331

Product References and Citations for Ogdh recombinant protein

"Prediction of the coding sequences of mouse homologues of KIAA gene. The complete nucleotide sequences of mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries." Okazaki N., Kikuno R.F., Ohara R., Inamoto S., Nagase T., Ohara O., Koga H. Submitted (FEB-2005)

Other Notes

Small volumes of Ogdh recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Ogdh purchase

MBS1438331 is a recombinant protein targeting Ogdh. Also known as Recombinant Mouse 2-oxoglutarate dehydrogenase, mitochondrial. Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for Ogdh. It may not necessarily be applicable to this product.

NCBI GI #
356582477
NCBI GeneID
18293
NCBI Accession #
NP_001239211.1
UniProt Primary Accession #
Q60597
UniProt Secondary Accession #
Q3UDM7; Q5DTI4; Q5SVX7; Q5SVX9; Q6PFZ2; Q80Y57; Q8K0K7; Q8K2Z3; Q8R3M2; Q91WP2
UniProt Related Accession #
Q60597
GenBank Nucleotide #
NM_001252282.1
NCBI Official Full Name
2-oxoglutarate dehydrogenase, mitochondrial isoform 1
NCBI Official Synonym Full Names
oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)
NCBI Official Symbol
Ogdh
NCBI Official Synonym Symbols
d1401; AA409584; mKIAA4192; 2210403E04Rik; 2210412K19Rik
UniProt Protein Name
2-oxoglutarate dehydrogenase, mitochondrial
UniProt Synonym Protein Names
2-oxoglutarate dehydrogenase complex component E1; OGDC-E1; Alpha-ketoglutarate dehydrogenase
Protein Family
2-oxoglutarate dehydrogenase
UniProt Gene Name
Ogdh
UniProt Synonym Gene Names
Kiaa4192; OGDC-E1
UniProt Entry Name
ODO1_MOUSE
NCBI Protein Information
2-oxoglutarate dehydrogenase, mitochondrial

UniProt Comments for Ogdh

OGDH: The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components: 2- oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3). Belongs to the alpha-ketoglutarate dehydrogenase family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Amino Acid Metabolism - lysine degradation; Amino Acid Metabolism - tryptophan; Carbohydrate Metabolism - citrate (TCA) cycle; Mitochondrial; Oxidoreductase; EC 1.2.4.2

Cellular Component: mitochondrion; oxoglutarate dehydrogenase complex

Molecular Function: chaperone binding; heat shock protein binding; metal ion binding; oxidoreductase activity; oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor; oxoglutarate dehydrogenase (succinyl-transferring) activity; thiamin pyrophosphate binding

Biological Process: 2-oxoglutarate metabolic process; glycolysis; metabolic process; NADH metabolic process; succinyl-CoA metabolic process; tricarboxylic acid cycle
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Research Articles on Ogdh

1. The nitration degree of alpha-OGDH for diabetic mouse is higher than that for control mouse, indicating that alpha-OGDH of the diabetic mouse suffered from more intense oxidative damage.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with Ogdh recombinant protein

 Reference Product  PubMed Publications
 Idh3a recombinant protein  >1 publications with Ogdh and Idh3a
 Idh2 recombinant protein  >1 publications with Ogdh and Idh2
 Dlst recombinant protein  >1 publications with Ogdh and Dlst

Pathways associated with Ogdh recombinant protein

 Products by Pathway  Pathway Diagram
 2-amino-3-carboxymuconate Semialdehyde Degradation To Glutaryl-CoA Pathway antibodies  2-amino-3-carboxymuconate Semialdehyde Degradation To Glutaryl-CoA Pathway Diagram
 2-ketoglutarate Dehydrogenase Complex Pathway antibodies  2-ketoglutarate Dehydrogenase Complex Pathway Diagram
 Amino Acid Metabolism Pathway antibodies  Amino Acid Metabolism Pathway Diagram
 Carbon Metabolism Pathway antibodies  Carbon Metabolism Pathway Diagram
 Carbon Metabolism Pathway antibodies  Carbon Metabolism Pathway Diagram
 Citrate Cycle (TCA Cycle) Pathway antibodies  Citrate Cycle (TCA Cycle) Pathway Diagram
 Citrate Cycle (TCA Cycle) Pathway antibodies  Citrate Cycle (TCA Cycle) Pathway Diagram
 Citrate Cycle (TCA Cycle, Krebs Cycle) Pathway antibodies  Citrate Cycle (TCA Cycle, Krebs Cycle) Pathway Diagram
 Citrate Cycle (TCA Cycle, Krebs Cycle) Pathway antibodies  Citrate Cycle (TCA Cycle, Krebs Cycle) Pathway Diagram
 Citrate Cycle, Second Carbon Oxidation, 2-oxoglutarate => Oxaloacetate Pathway antibodies  Citrate Cycle, Second Carbon Oxidation, 2-oxoglutarate => Oxaloacetate Pathway Diagram

Diseases associated with Ogdh recombinant protein

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >4 publications with Ogdh and Nervous System Diseases
 Heart Diseases Antibodies  >3 publications with Ogdh and Heart Diseases
 Cardiovascular Diseases Antibodies  >3 publications with Ogdh and Cardiovascular Diseases
 Breast Neoplasms Antibodies  >2 publications with Ogdh and Breast Neoplasms
 Brain Diseases Antibodies  >2 publications with Ogdh and Brain Diseases
 Disease Models, Animal Antibodies  >2 publications with Ogdh and Disease Models, Animal
 Liver Diseases Antibodies  >2 publications with Ogdh and Liver Diseases
 Cell Transformation, Neoplastic Antibodies  >1 publications with Ogdh and Cell Transformation, Neoplastic
 Liver Cirrhosis Antibodies  >1 publications with Ogdh and Liver Cirrhosis
 Fatty Liver Antibodies  >1 publications with Ogdh and Fatty Liver

Organs/Tissues associated with Ogdh recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >16 publications with Ogdh and Muscle
 Heart Antibodies  >9 publications with Ogdh and Heart
 Liver Antibodies  >8 publications with Ogdh and Liver
 Brain Antibodies  >6 publications with Ogdh and Brain
 Pancreas Antibodies  >3 publications with Ogdh and Pancreas
 Kidney Antibodies  >3 publications with Ogdh and Kidney
 Stomach Antibodies  >2 publications with Ogdh and Stomach
 Connective Tissue Antibodies  >2 publications with Ogdh and Connective Tissue
 Bone Antibodies  >2 publications with Ogdh and Bone
 Eye Antibodies  >1 publications with Ogdh and Eye
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