Mouse mMDC Active Protein – Cat# MBS143921

Macrophage-Derived Chemokine (mMDC) Mouse Active Protein

Name: mMDC Active Protein; Macrophage-Derived Chemokine; Mouse; MyBioSource
Brand: MyBioSource
SKU: MBS143921
Price: 250 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS143921

Description: CCL22 Mouse Recombinant produced in E Coli is a non-glycosylated, Polypeptide chain containing 68 amino acids and having a molecular mass of 7.8kDa. The Mouse CCL22 is purified by proprietary chromatographic techniques.Introduction: MDC (CCL22)… More details

$250 / 0.005 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Macrophage-Derived Chemokine (mMDC), Active Protein

Full Product Name

Recombinant Mouse Macrophage-Derived Chemokine (CCL22)

Product Gene Name

mMDC active protein

Product Synonym Names

MDC Mouse; Macrophage-Derived Chemokine Mouse Recombinant (CCL22); C-C motif chemokine 22; Small-inducible cytokine A22; Macrophage-derived chemokine; MDC(1-69); Stimulated T-cell chemotactic protein 1; CC chemokine STCP-1; CCL22; MDC; SCYA22; ABCD-1; DC/B-CK; MGC34554; A-152E5.1; CC chemokine ABCD-1; Activated B and dendritic cell-derived; DCBCK

Sequence

GPYGANVEDS ICCQDYIRHP LPSRLVKEFF WTSKSCRKPG VVLITVKNRD ICADPRQVWV KKLLHKLS

Host

E Coli

Form/Format

CCL22 filtered (0.2 um) and lyophilized from a concentrated solution containing 20mM phosphate buffer & 150mM NaCl pH-7.4.
Filtered White lyophilized (freeze-dried) powder.

Purity/Purification

Greater than 97.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.

Preparation and Storage

Lyophilized CCL22 although stable at room temperature for 3 weeks, should be stored desiccated below -18 degree C. Upon reconstitution CCL22 should be stored at 4 degree C between 2-7 days and for future use below -18 degree C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.

Molecular Weight

10,302 Da

3D Structure

ModBase 3D Structure for O88430

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Solubility

It is recommended to reconstitute the lyophilized CCL22 in sterile 18M Omega -cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions.

Biological Activity

Determined by its ability to chemoattract human activated lymphocytes using a concentration range of 10-100ng/ml corresponding to a Specific Activity of 10,000-100,000IU/mg.

Product Categories/Family for mMDC active protein

Chemokines; MDC (CCL22)

Other Notes

Small volumes of mMDC active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for mMDC purchase

MBS143921 is an active protein targeting mMDC. Also known as Recombinant Mouse Macrophage-Derived Chemokine (CCL22). Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for mMDC. It may not necessarily be applicable to this product.

NCBI GI #

6677879

NCBI GeneID

20299

NCBI Accession #

NP_033163.1

UniProt Primary Accession #

O88430

UniProt Related Accession #

O88430

GenBank Nucleotide #

NM_009137.2

NCBI Official Full Name

C-C motif chemokine 22

NCBI Official Synonym Full Names

chemokine (C-C motif) ligand 22

NCBI Official Symbol

Ccl22

NCBI Official Synonym Symbols

MDC; DCBCK; ABCD-1; Scya22

UniProt Protein Name

C-C motif chemokine 22

UniProt Synonym Protein Names

Activated B and dendritic cell-derived; CC chemokine ABCD-1; Small-inducible cytokine A22

UniProt Gene Name

Ccl22

UniProt Synonym Gene Names

Abcd1; Scya22

UniProt Entry Name

CCL22_MOUSE

NCBI Protein Information

C-C motif chemokine 22; CC chemokine ABCD-1; SMALL INDUCIBLE CYTOKINE A22 PRECURSOR (CC CHEMOKINE ABCD-1) (ACTIVATED B AND DENDRITIC CELL-DERIVED); activated B and dendritic cell-derived; dendritic cell and B cell derived chemokine; small inducible cytokine subfamily A, member 22; small inducible cytokine subfamily A22; small-inducible cytokine A22

UniProt Comments for mMDC

CCL22: May play a role in the trafficking of activated/effector T-lymphocytes to inflammatory sites and other aspects of activated T-lymphocyte physiology. Chemotactic for monocytes, dendritic cells and natural killer cells. Mild chemoattractant for primary activated T-lymphocytes and a potent chemoattractant for chronically activated T-lymphocytes but has no chemoattractant activity for neutrophils, eosinophils, and resting T-lymphocytes. Binds to CCR4. Processed forms MDC(3-69), MDC(5-69) and MDC(7-69) seem not be active. Belongs to the intercrine beta (chemokine CC) family.

Protein type: Secreted; Motility/polarity/chemotaxis; Chemokine; Secreted, signal peptide

Cellular Component: extracellular space; extracellular region

Molecular Function: chemokine activity; cytokine activity

Biological Process: immune response; inflammatory response; chemotaxis

Research Articles on mMDC

1. Data indicate macrophage-derived chemokine CCL22 as an adjuvant could enhance the immune protective effect of NTHi-P6 protein vaccine to an extent.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with mMDC active protein

Reference Product	PubMed Publications
Ccr4 active protein	>225 publications with mMDC and Ccr4
Ccl11 active protein	>58 publications with mMDC and Ccl11
Cxcr3 active protein	>44 publications with mMDC and Cxcr3
Ccr5 active protein	>41 publications with mMDC and Ccr5
Ccr7 active protein	>41 publications with mMDC and Ccr7
Ccr3 active protein	>27 publications with mMDC and Ccr3
Ccr8 active protein	>25 publications with mMDC and Ccr8
Ccl7 active protein	>22 publications with mMDC and Ccl7
Ccr1 active protein	>17 publications with mMDC and Ccr1
Ccr2 active protein	>16 publications with mMDC and Ccr2

Pathways associated with mMDC active protein

Products by Pathway	Pathway Diagram
Chemokine Receptors Bind Chemokines Pathway antibodies	Chemokine Receptors Bind Chemokines Pathway Diagram
Chemokine Signaling Pathway antibodies	Chemokine Signaling Pathway Diagram
Chemokine Signaling Pathway antibodies	Chemokine Signaling Pathway Diagram
Chemokine Signaling Pathway antibodies	Chemokine Signaling Pathway Diagram
Class A/1 (Rhodopsin-like Receptors) Pathway antibodies	Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway antibodies	Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway Diagram
Disease Pathway antibodies	Disease Pathway Diagram
GPCR Ligand Binding Pathway antibodies	GPCR Ligand Binding Pathway Diagram

Diseases associated with mMDC active protein

Disease Name	Pubmed Publications
Inflammation Antibodies	>187 publications with mMDC and Inflammation
Hypersensitivity Antibodies	>144 publications with mMDC and Hypersensitivity
Skin Diseases Antibodies	>125 publications with mMDC and Skin Diseases
Respiratory Tract Diseases Antibodies	>118 publications with mMDC and Respiratory Tract Diseases
Lung Diseases Antibodies	>103 publications with mMDC and Lung Diseases
Necrosis Antibodies	>75 publications with mMDC and Necrosis
Dermatitis, Atopic Antibodies	>71 publications with mMDC and Dermatitis, Atopic
Respiratory Hypersensitivity Antibodies	>63 publications with mMDC and Respiratory Hypersensitivity
Carcinoma Antibodies	>45 publications with mMDC and Carcinoma
Liver Diseases Antibodies	>17 publications with mMDC and Liver Diseases

Organs/Tissues associated with mMDC active protein

Organ/Tissue Name	Pubmed Publications
Thymus Antibodies	>135 publications with mMDC and Thymus
Skin Antibodies	>124 publications with mMDC and Skin
Lymph Node Antibodies	>66 publications with mMDC and Lymph Node
Spleen Antibodies	>31 publications with mMDC and Spleen
Thyroid Antibodies	>3 publications with mMDC and Thyroid
Salivary Gland Antibodies	>3 publications with mMDC and Salivary Gland