Human FKBP3 Active Protein – Cat# MBS143927

FK506 Binding Protein 3 (FKBP3) Human Active Protein

Name: FKBP3 Active Protein; FK506 Binding Protein 3; Human; MyBioSource
Brand: MyBioSource
SKU: MBS143927
Price: 250 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS143927

Description: FKBP3 produced in E Coli is a single, non-glycosylated polypeptide chain containing 224 amino acids (1-224 a.a.) and having a molecular mass of 25.1 kDa. FKBP3 is purified by proprietary chromatographic techniques.Introduction: FKBP3 is part of a… More details

$250 / 0.005 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

FK506 Binding Protein 3 (FKBP3), Active Protein

Full Product Name

Recombinant Human FK506 Binding Protein 3

Product Gene Name

FKBP3 active protein

Product Synonym Names

FKBP3 Human; FK506 Binding Protein 3 Human Recombinant; EC 5.2.1.8; FKBP-3; FKBP25; FKBP-25; Peptidyl-prolyl cis-trans isomerase FKBP3; PPIase FKBP3; FK506-binding protein 3; Rotamase; Immunophilin FKBP25; 25 kDa FK506-binding protein; 25 kDa FKBP; Rapamycin-selective 25 kDa immunophilin; FKBP3; PPIase

Sequence

MAAAVPQRAW TVEQLRSEQL PKKDIIKFLQ EHGSDSFLAE HKLLGNIKNV AKTANKDHLV TAYNHLFETK RFKGTESISK VSEQVKNVKL NEDKPKETKS EETLDEGPPK YTKSVLKKGD KTNFPKKGDV VHCWYTGTLQ DGTVFDTNIQ TSAKKKKNAK PLSFKVGVGK VIRGWDEALL TMSKGEKARL EIEPEWAYGK KGQPDAKIPP NAKLTFEVEL VDID

Host

E Coli

Form/Format

The FKBP3 protein solution contains 20mM Tris-HCl, pH-8, 1mM DTT and 10% glycerol.
Sterile filtered colorless solution.

Purity/Purification

Greater than 90.0% as determined by SDS-PAGE.

Preparation and Storage

Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.

Molecular Weight

25,177 Da

OMIM

186947

3D Structure

ModBase 3D Structure for Q00688

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Biological Activity

Specific activity is > 490 nmoles/min/mg, and is defined as the amount of enzyme that cleaves 1umole of suc-AAFP-pNA per minute at 25C in Tris-Hcl pH8.0 using chymotrypsin.

Product Categories/Family for FKBP3 active protein

Enzymes; FK506 Binding Protein

Other Notes

Small volumes of FKBP3 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for FKBP3 purchase

MBS143927 is an active protein targeting FKBP3. Also known as Recombinant Human FK506 Binding Protein 3. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for FKBP3. It may not necessarily be applicable to this product.

NCBI GI #

4503727

NCBI GeneID

2287

NCBI Accession #

NP_002004.1

UniProt Primary Accession #

Q00688

UniProt Secondary Accession #

Q14317; B2R4Q9

UniProt Related Accession #

Q00688

GenBank Nucleotide #

NM_002013.3

NCBI Official Full Name

peptidyl-prolyl cis-trans isomerase FKBP3

NCBI Official Synonym Full Names

FK506 binding protein 3, 25kDa

NCBI Official Symbol

FKBP3

NCBI Official Synonym Symbols

FKBP-3; FKBP25; PPIase; FKBP-25

UniProt Protein Name

Peptidyl-prolyl cis-trans isomerase FKBP3

UniProt Synonym Protein Names

25 kDa FK506-binding protein; 25 kDa FKBP; FKBP-25; FK506-binding protein 3; FKBP-3; Immunophilin FKBP25; Rapamycin-selective 25 kDa immunophilin; Rotamase

Protein Family

FK506-binding protein

UniProt Gene Name

FKBP3

UniProt Synonym Gene Names

FKBP25; PPIase FKBP3; 25 kDa FKBP; FKBP-25; FKBP-3

UniProt Entry Name

FKBP3_HUMAN

NCBI Protein Information

peptidyl-prolyl cis-trans isomerase FKBP3; 25 kDa FK506-binding protein; 25 kDa FKBP; FK506-binding protein 25, T-cell; FK506-binding protein 3 (25kD); PPIase FKBP3; immunophilin FKBP25; rapamycin binding protein; rapamycin-selective 25 kDa immunophilin; rotamase

NCBI Summary for FKBP3

The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin, as well as histone deacetylases, the transcription factor YY1, casein kinase II, and nucleolin. It has a higher affinity for rapamycin than for FK506 and thus may be an important target molecule for immunosuppression by rapamycin. [provided by RefSeq, Sep 2008]

UniProt Comments for FKBP3

FKBP3: FK506- and rapamycin-binding proteins (FKBPs) constitute a family of receptors for the two immunosuppressants which inhibit T-cell proliferation by arresting two distinct cytoplasmic signal transmission pathways. PPIases accelerate the folding of proteins. Belongs to the FKBP-type PPIase family.

Protein type: EC 5.2.1.8; Isomerase

Chromosomal Location of Human Ortholog: 14q21.2

Cellular Component: endoplasmic reticulum membrane; nucleus

Molecular Function: protein binding; peptidyl-prolyl cis-trans isomerase activity; FK506 binding; receptor activity

Biological Process: protein peptidyl-prolyl isomerization

Research Articles on FKBP3

1. proteomics study indicates that the nuclear pool of the FKBP25 targets various nuclear proteins that are crucial for packaging of DNA, chromatin remodeling and pre-mRNA splicing

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with FKBP3 active protein

Reference Product	PubMed Publications
HDAC1 active protein	>1 publications with FKBP3 and HDAC1

Pathways associated with FKBP3 active protein

Products by Pathway	Pathway Diagram
Integrated Pancreatic Cancer Pathway antibodies	Integrated Pancreatic Cancer Pathway Diagram
Signaling Events Mediated By HDAC Class I Pathway antibodies	Signaling Events Mediated By HDAC Class I Pathway Diagram

Diseases associated with FKBP3 active protein

Disease Name	Pubmed Publications
Immune System Diseases Antibodies	>1 publications with FKBP3 and Immune System Diseases
Liver Diseases Antibodies	>1 publications with FKBP3 and Liver Diseases
Inflammation Antibodies	>1 publications with FKBP3 and Inflammation

Organs/Tissues associated with FKBP3 active protein

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>4 publications with FKBP3 and Brain
Liver Antibodies	>2 publications with FKBP3 and Liver
Ovary Antibodies	>1 publications with FKBP3 and Ovary
Eye Antibodies	>1 publications with FKBP3 and Eye
Testis Antibodies	>1 publications with FKBP3 and Testis
Heart Antibodies	>1 publications with FKBP3 and Heart
Blood Antibodies	>1 publications with FKBP3 and Blood
Muscle Antibodies	>1 publications with FKBP3 and Muscle
Embryonic Tissue Antibodies	>1 publications with FKBP3 and Embryonic Tissue