Porcine pCD163 Recombinant Protein – Cat# MBS143958

CD163 (pCD163) Porcine Recombinant Protein

Name: pCD163 Recombinant Protein; CD163; Porcine; MyBioSource
Brand: MyBioSource
SKU: MBS143958
Price: 250 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS143958

Description: CD163 Porcine Recombinant produced in E Coli is a single, non-glycosylated, polypeptide chain containing 805 amino acids and having a molecular mass of 87kDa.The CD163 is fused to an 8 amino acid His Tag at C-terminus and purified by proprietary… More details

$250 / 0.01 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

CD163 (pCD163), Recombinant Protein

Full Product Name

Recombinant Porcine CD163

Product Gene Name

pCD163 recombinant protein

Product Synonym Names

CD163 Porcine; CD163 Porcine Recombinant; CD-163; Hemoglobin scavenger receptor; macrophage-associated antigen; M130; sCD163; CD163; MM130

Sequence

MDKLRMVLHE NSGSADLKLR VVDGVTECSG RLEVKFQGEW GTICDDGWDS DDAAVACKQL GCPTAVTAIG RVNASEGTGH IWLDSVSCHG HESALWQCRH HEWGKHYCNH NEDAGVTCSD GSDLELRLKG GGSHCAGTVE VEIQKLVGKV CDRSWGLKEA DVVCRQLGCG SALKTSYQVY SKTKATNTWL FVSSCNGNET SLWDCKNWQW GGLSCDHYDE AKITCSAHRK PRLVGGDIPC SGRVEVQHGD TWGTVCDSDF SLEAASVLCR ELQCGTVVSL LGGAHFGEGS GQIWAEEFQC EGHESHLSLC PVAPRPDGTC SHSRDVGVVC SRYTQIRLVN GKTPCEGRVE LNILGSWGSL CNSHWDMEDA HVLCQQLKCG VALSIPGGAP FGKGSEQVWR HMFHCTGTEK HMGDCSVTAL GASLCSSGQV ASVICSGNQS QTLSPCNSSS SDPSSSIISE ENGVACIGSG QLRLVDGGGR CAGRVEVYHE GSWGTICDDS WDLNDAHVVC KQLSCGWAIN ATGSAHFGEG TGPIWLDEIN CNGKESHIWQ CHSHGWGRHN CRHKEDAGVI CSEFMSLRLI SENSRETCAG RLEVFYNGAW GSVGKNSMSP ATVGVVCRQL GCADRGDISP ASSDKTVSRH MWVDNVQCPK GPDTLWQCPS SPWKKRLASP SEETWITCAN KIRLQEGNTN CSGRVEIWYG GSWGTVCDDS WDLEDAQVVC RQLGCGSALE AGKEAAFGQG TGPIWLNEVK CKGNETSLWD CPARSWGHSD CGHKEDAAVT CSEIAKSRES LHATGRSHHH HHHHH

Host

E Coli

Form/Format

The protein was lyophilized from a 0.2 um filtered concentrated solution in 1xPBS, pH 7.4, containing 4M Urea.

Purity/Purification

Greater than 95.0% as determined by: (a) Analysis by HPLC. (b) Analysis by SDS-PAGE.

Preparation and Storage

Lyophilized CD163 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution CD163 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.

3D Structure

ModBase 3D Structure for Q2VL90

Solubility

It is recommended to reconstitute the lyophilized CD163 in sterile 18M Omega -cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions.

Appearance

Sterile Filtered White lyophilized (freeze-dried) powder

Product Categories/Family for pCD163 recombinant protein

Recombinant & Natural Proteins; CD Antigens

Other Notes

Small volumes of pCD163 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for pCD163 purchase

MBS143958 is a recombinant protein targeting pCD163. Also known as Recombinant Porcine CD163. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for pCD163. It may not necessarily be applicable to this product.

NCBI GI #

47522778

NCBI GeneID

397031

NCBI Accession #

NP_999141.1

UniProt Primary Accession #

Q2VL90

UniProt Secondary Accession #

Q2VL89; Q8HY22

UniProt Related Accession #

Q2VL90

GenBank Nucleotide #

NM_213976.1

NCBI Official Full Name

scavenger receptor cysteine-rich type 1 protein M130

NCBI Official Symbol

CD163

UniProt Protein Name

Scavenger receptor cysteine-rich type 1 protein M130

UniProt Synonym Protein Names

CD_antigen: CD163Soluble CD163; sCD163

Protein Family

Scavenger receptor cysteine-rich type 1 protein

UniProt Gene Name

CD163

UniProt Synonym Gene Names

M130; sCD163

UniProt Entry Name

C163A_PIG

NCBI Protein Information

scavenger receptor cysteine-rich type 1 protein M130

UniProt Comments for pCD163

Involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1 (). May play a role in the process of infection of porcine monocytes/macrophages by African swine fever virus (ASFV). In case of porcine reproductive and respiratory syndrome virus (PRRSV), serves mediates virion attachment and plays a role in viral entry.

Research Articles on pCD163

1. Overexpression of ADAM17 induced downregulation of CD163 expression and a reduction in reproductive and respiratory syndrome virus infection.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with pCD163 recombinant protein

Disease Name	Pubmed Publications
Inflammation Antibodies	>401 publications with pCD163 and Inflammation
Necrosis Antibodies	>180 publications with pCD163 and Necrosis
Cardiovascular Diseases Antibodies	>115 publications with pCD163 and Cardiovascular Diseases
Nervous System Diseases Antibodies	>108 publications with pCD163 and Nervous System Diseases
Brain Diseases Antibodies	>67 publications with pCD163 and Brain Diseases
Disease Models, Animal Antibodies	>66 publications with pCD163 and Disease Models, Animal
Fibrosis Antibodies	>60 publications with pCD163 and Fibrosis
Lung Diseases Antibodies	>55 publications with pCD163 and Lung Diseases
Adenocarcinoma Antibodies	>43 publications with pCD163 and Adenocarcinoma
Heart Diseases Antibodies	>38 publications with pCD163 and Heart Diseases

Organs/Tissues associated with pCD163 recombinant protein

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>653 publications with pCD163 and Blood
Skin Antibodies	>121 publications with pCD163 and Skin
Liver Antibodies	>113 publications with pCD163 and Liver
Lung Antibodies	>80 publications with pCD163 and Lung
Muscle Antibodies	>79 publications with pCD163 and Muscle
Bone Marrow Antibodies	>72 publications with pCD163 and Bone Marrow
Lymph Antibodies	>70 publications with pCD163 and Lymph
Lymph Node Antibodies	>66 publications with pCD163 and Lymph Node
Joint Antibodies	>60 publications with pCD163 and Joint
Heart Antibodies	>47 publications with pCD163 and Heart