Human CLIC1 Recombinant Protein – Cat# MBS143959

Chloride Intracellular Channel 1 (CLIC1) Human Recombinant Protein

Name: CLIC1 Recombinant Protein; Human; MyBioSource
Brand: MyBioSource
SKU: MBS143959
Price: 250 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS143959

Description: CLIC1 Human Recombinant produced in E Coli is a single, non-glycosylated, polypeptide chain containing 261amino acids (1-241a.a.) and having a molecular mass of 29 kDa. CLIC1 protein is fused to a 20 amino acid His tag at N-terminus and is… More details

$250 / 0.005 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Chloride Intracellular Channel 1 (CLIC1), Recombinant Protein

Full Product Name

Recombinant Human Chloride Intracellular Channel 1

Product Gene Name

CLIC1 recombinant protein

Product Synonym Names

CLIC1 Human; Chloride Intracellular Channel 1 Human Recombinant; ACBP; ACBD1; CCK-RP; EP; CLIC1; G6; NCC27; Nuclear chloride ion channel 27; Chloride channel ABP; Regulatory nuclear chloride ion channel protein; hRNCC; Chloride intracellular channel protein 1

Sequence

GSSHHHH HH SSGLVPRGSH MAEEQPQVEL FVKAGSDGAK IGNCPFSQRL FMVLWLKGVT FNVTTVDTKR RTETVQKLCP GGQLPFLLYG TEVHTDTNKI EEFLEAVLCP PRYPKLAALN PESNTAGLDI FAKFSAYIKN SNPALNDNLE KGLLKALKVL DNYLTSPLPE EVDETSAEDE GVSQRKFLDG NELTLADCNL LPKLHIVQVV CKKYRGFTIP EAFRGVHRYL SNAYAREEFA STCPDDEEIE LAYEQVAKAL K

Host

E Coli

Form/Format

1mg/ml solution containing 20mM Tris-HCl pH-8, 0.1M NaCl & 10% glycerol.
Sterile filtered colorless solution.

Purity/Purification

Greater than 90% as determined by SDS-PAGE.

Concentration

1mg/ml (lot specific)

Preparation and Storage

Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time.
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Avoid multiple freeze-thaw cycles.

Molecular Weight

26,923 Da

OMIM

602872

3D Structure

ModBase 3D Structure for O00299

Product Categories/Family for CLIC1 recombinant protein

Recombinant & Natural Proteins; Recombinant Proteins; Chloride Intracellular Channel

Other Notes

Small volumes of CLIC1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CLIC1 purchase

MBS143959 is a recombinant protein targeting CLIC1. Also known as Recombinant Human Chloride Intracellular Channel 1. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for CLIC1. It may not necessarily be applicable to this product.

NCBI GI #

567757607

NCBI GeneID

1192

NCBI Accession #

NP_001274522.1

UniProt Primary Accession #

O00299

UniProt Secondary Accession #

Q15089; Q502X1

UniProt Related Accession #

O00299

GenBank Nucleotide #

NM_001287593.1

NCBI Official Full Name

chloride intracellular channel protein 1

NCBI Official Synonym Full Names

chloride intracellular channel 1

NCBI Official Symbol

CLIC1

NCBI Official Synonym Symbols

G6; NCC27

UniProt Protein Name

Chloride intracellular channel protein 1

UniProt Synonym Protein Names

Chloride channel ABP; Nuclear chloride ion channel 27; NCC27; Regulatory nuclear chloride ion channel protein; hRNCC

Protein Family

Chloride intracellular channel protein

UniProt Gene Name

CLIC1

UniProt Synonym Gene Names

G6; NCC27; NCC27; hRNCC

UniProt Entry Name

CLIC1_HUMAN

NCBI Protein Information

chloride intracellular channel protein 1; RNCC protein; chloride channel ABP; hRNCC; nuclear chloride ion channel 27; nuclear chloride ion channel protein; p64CLCP; regulatory nuclear chloride ion channel protein

NCBI Summary for CLIC1

Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 1 is a member of the p64 family; the protein localizes principally to the cell nucleus and exhibits both nuclear and plasma membrane chloride ion channel activity. [provided by RefSeq, Jul 2008]

UniProt Comments for CLIC1

CLIC1: Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Involved in regulation of the cell cycle. Belongs to the chloride channel CLIC family.

Protein type: Membrane protein, integral; Channel, chloride

Chromosomal Location of Human Ortholog: 6p21.3

Cellular Component: extracellular space; nuclear membrane; mitochondrion; membrane; perinuclear region of cytoplasm; cytoplasm; plasma membrane; nuclear envelope; nucleus; vesicle; brush border

Molecular Function: chloride channel activity; protein binding; voltage-gated ion channel activity

Biological Process: positive regulation of osteoblast differentiation; regulation of mitochondrial membrane potential; regulation of cell cycle; chloride transport; signal transduction

Research Articles on CLIC1

1. Mutation of the two charged amino acids (K37 and R29) in the putative transmembrane region of CLIC1 alters the biophysical properties of the ion channel in both artificial bilayers and cells.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with CLIC1 recombinant protein

Disease Name	Pubmed Publications
Liver Diseases Antibodies	>8 publications with CLIC1 and Liver Diseases
Nervous System Diseases Antibodies	>8 publications with CLIC1 and Nervous System Diseases
Liver Neoplasms Antibodies	>8 publications with CLIC1 and Liver Neoplasms
Brain Diseases Antibodies	>7 publications with CLIC1 and Brain Diseases
Neoplasm Metastasis Antibodies	>7 publications with CLIC1 and Neoplasm Metastasis
Carcinoma, Hepatocellular Antibodies	>6 publications with CLIC1 and Carcinoma, Hepatocellular
Necrosis Antibodies	>5 publications with CLIC1 and Necrosis
Inflammation Antibodies	>4 publications with CLIC1 and Inflammation
Cardiovascular Diseases Antibodies	>2 publications with CLIC1 and Cardiovascular Diseases
Hemorrhage Antibodies	>1 publications with CLIC1 and Hemorrhage

Organs/Tissues associated with CLIC1 recombinant protein

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>11 publications with CLIC1 and Blood
Brain Antibodies	>9 publications with CLIC1 and Brain
Liver Antibodies	>8 publications with CLIC1 and Liver
Muscle Antibodies	>6 publications with CLIC1 and Muscle
Bone Antibodies	>6 publications with CLIC1 and Bone
Kidney Antibodies	>6 publications with CLIC1 and Kidney
Stomach Antibodies	>4 publications with CLIC1 and Stomach
Lymph Antibodies	>3 publications with CLIC1 and Lymph
Vascular Antibodies	>3 publications with CLIC1 and Vascular
Lymph Node Antibodies	>3 publications with CLIC1 and Lymph Node