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Dynein Light Chain Roadblock-Type 1 (DYNLRB1) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS143977

Description: DYNLRB1 Recombinant Human produced in E Coli is a single, non-glycosylated polypeptide chain containing 104 amino acids (1-96 a.a.) and having a molecular mass of 11.9 kDa. The DYNLRB1 is fused to 8 amino acid His-Tag at C-terminus and purified… More details

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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
Dynein Light Chain Roadblock-Type 1 (DYNLRB1), Recombinant Protein
Full Product Name
Recombinant Human Dynein Light Chain Roadblock-Type 1
Product Synonym Names
DYNLRB1 Human; Dynein Light Chain Roadblock-Type 1 Human Recombinant; BITH; BLP; DNCL2A; DNLC2A; ROBLD1; HSPC162
Sequence
MAEVEETLKR LQSQKGVQGI IVVNTEGIPI KSTMDNPTTT QYASLMHSFI LKARSTVRDI DPQNDLTFLR IRSKKNEIMV APDKDYFLIV IQNPTEL EHH HHHH
Host
E Coli
Form/Format
1mg/ml solution containing 20mM Tris pH-8, & 10% glycerol.
Sterile filtered colorless solution.
Purity/Purification
Greater than 95.0% as determined by SDS-PAGE.
Preparation and Storage
DYNLRB1 Human although stable at 4C for 1 week, should be stored below -18C. Please prevent freeze thaw cycles.
Molecular Weight
5,060 Da
OMIM
607167
3D Structure
ModBase 3D Structure for Q9NP97

Other Notes

Small volumes of DYNLRB1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for DYNLRB1 purchase

MBS143977 is a recombinant protein targeting DYNLRB1. Also known as Recombinant Human Dynein Light Chain Roadblock-Type 1. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for DYNLRB1. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
dynein light chain roadblock-type 1 isoform b
NCBI Official Synonym Full Names
dynein, light chain, roadblock-type 1
NCBI Official Symbol
DYNLRB1
NCBI Official Synonym Symbols
BLP; BITH; DNCL2A; DNLC2A; ROBLD1
UniProt Protein Name
Dynein light chain roadblock-type 1
UniProt Synonym Protein Names
Bithoraxoid-like protein; BLP; Dynein light chain 2A, cytoplasmic; Dynein-associated protein Km23; Roadblock domain-containing protein 1
Protein Family
UniProt Gene Name
DYNLRB1
UniProt Synonym Gene Names
BITH; DNCL2A; DNLC2A; ROBLD1; BLP
UniProt Entry Name
DLRB1_HUMAN
NCBI Protein Information
dynein light chain roadblock-type 1; ROBL/LC7-like 1; bithoraxoid-like protein; dynein, cytoplasmic, light polypeptide 2A; dynein-associated protein Km23; roadblock domain-containing protein 1

NCBI Summary for DYNLRB1

This gene is a member of the roadblock dynein light chain family. The encoded cytoplasmic protein is capable of binding intermediate chain proteins, interacts with transforming growth factor-beta, and has been implicated in the regulation of actin modulating proteins. Upregulation of this gene has been associated with hepatocellular carcinomas, suggesting that this gene may be involved in tumor progression. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene have been defined on chromosomes 12 and 18. [provided by RefSeq, Aug 2013]
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UniProt Comments for DYNLRB1

DYNLRB1: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Belongs to the GAMAD family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 20q11.21

Cellular Component: microtubule; centrosome; membrane; cytoplasmic dynein complex; cytoplasm

Molecular Function: microtubule motor activity

Biological Process: metabolic process; transport; organelle organization and biogenesis; microtubule-based movement; visual behavior
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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