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Fission-1 (FIS1) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS143982

Description: FIS1 Human Recombinant produced in E Coli is a single, non-glycosylated, polypeptide chain containing 142 amino acids (1-122 a.a.) and having a molecular mass of 16.3 kDa. FIS1 protein is fused to a 20 amino acid His tag at N-terminus and is… More details

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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
Fission-1 (FIS1), Recombinant Protein
Full Product Name
Recombinant Human Fission-1
Product Gene Name
FIS1 recombinant protein
Product Synonym Names
FIS1 Human; Fission-1 Human Recombinant; TTC11; Tetratricopeptide repeat domain 11; Fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)
Sequence
MGSSHHH HHH SSGLVPRGSH MEAVLNELVS VEDLLKFEKK FQSEKAAGSV SKSTQFEYAW CLVRSKYNDD IRKGIVLLEE LLPKGSKEEQ RDYVFYLAVG NYRLKEYEKA LKYVRGLLQT EPQNNQAKEL ERLIDKAMKK DG
Form/Format
FIS1 protein solution (1mg/ml) containing 20mM Tris-HCl pH-8 and 10% glycerol.
Purity/Purification
Greater than 95.0% as determined by SDS-PAGE.
Preparation and Storage
Store at 4°C if entire vial will be used within 2-4 weeks.
Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).

Avoid multiple freeze-thaw cycles.
OMIM
609003
3D Structure
ModBase 3D Structure for Q9Y3D6
Source
E.Coli
Physical Appearance
Sterile filtered colorless solution.

Product Categories/Family for FIS1 recombinant protein

Recombinant & Natural Proteins; Recombinant Proteins

Other Notes

Small volumes of FIS1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for FIS1 purchase

MBS143982 is a recombinant protein targeting FIS1. Also known as Recombinant Human Fission-1.

Additional Details

NCBI/Uniprot data below describe general gene information for FIS1. It may not necessarily be applicable to this product.

NCBI GI #
151108473
NCBI GeneID
51024
NCBI Accession #
NP_057152.2
UniProt Primary Accession #
Q9Y3D6
UniProt Secondary Accession #
Q9BTP3
UniProt Related Accession #
Q9Y3D6
GenBank Nucleotide #
NM_016068.2
NCBI Official Full Name
mitochondrial fission 1 protein
NCBI Official Synonym Full Names
fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)
NCBI Official Symbol
FIS1
NCBI Official Synonym Symbols
TTC11; CGI-135
UniProt Protein Name
Mitochondrial fission 1 protein
UniProt Synonym Protein Names
FIS1 homolog; hFis1; Tetratricopeptide repeat protein 11; TPR repeat protein 11
Protein Family
Mitochondria fission 1 protein
UniProt Gene Name
FIS1
UniProt Synonym Gene Names
TTC11; hFis1; TPR repeat protein 11
UniProt Entry Name
FIS1_HUMAN
NCBI Protein Information
mitochondrial fission 1 protein; FIS1 homolog; H_NH0132A01.6; TPR repeat protein 11; hFis1; tetratricopeptide repeat domain 11; tetratricopeptide repeat protein 11

NCBI Summary for FIS1

The balance between fission and fusion regulates the morphology of mitochondria. TTC11 is a component of a mitochondrial complex that promotes mitochondrial fission (James et al., 2003 [PubMed 12783892]).[supplied by OMIM, Mar 2008]

UniProt Comments for FIS1

FIS1: Promotes the fragmentation of the mitochondrial network and its perinuclear clustering. Can induce cytochrome c release from the mitochondrion to the cytosol, ultimately leading to apoptosis. Also mediates peroxisomal fission. Belongs to the FIS1 family.

Protein type: Membrane protein, integral; Mitochondrial

Chromosomal Location of Human Ortholog: 7q22.1

Cellular Component: integral to peroxisomal membrane; protein complex; mitochondrion; membrane; peroxisome; integral to mitochondrial outer membrane

Molecular Function: protein binding; receptor binding

Biological Process: peroxisome fission; mitochondrial fission; release of cytochrome c from mitochondria; elevation of cytosolic calcium ion concentration; mitochondrial fusion; reduction of endoplasmic reticulum calcium ion concentration; mitochondrion degradation; positive regulation of caspase activity; mitochondrial fragmentation during apoptosis; protein targeting to mitochondrion; protein homooligomerization; elevation of mitochondrial calcium ion concentration
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Research Articles on FIS1

1. PDCD7, Ang2 and FIS1 may indicate a more aggressive form and poor prognosis of acute myeloid leukemia.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with FIS1 recombinant protein

 Reference Product  PubMed Publications
 MFN1 recombinant protein  >48 publications with FIS1 and MFN1
 MFN2 recombinant protein  >46 publications with FIS1 and MFN2
 DNM1L recombinant protein  >40 publications with FIS1 and DNM1L
 PEX11A recombinant protein  >6 publications with FIS1 and PEX11A
 BCAP31 recombinant protein  >3 publications with FIS1 and BCAP31
 PEX11B recombinant protein  >3 publications with FIS1 and PEX11B
 GDAP1 recombinant protein  >2 publications with FIS1 and GDAP1
 PEX11G recombinant protein  >1 publications with FIS1 and PEX11G
 MARCH5 recombinant protein  >1 publications with FIS1 and MARCH5

Diseases associated with FIS1 recombinant protein

 Disease Name  Pubmed Publications
 Death Antibodies  >56 publications with FIS1 and Death
 Nervous System Diseases Antibodies  >31 publications with FIS1 and Nervous System Diseases
 Heart Diseases Antibodies  >8 publications with FIS1 and Heart Diseases
 Movement Disorders Antibodies  >5 publications with FIS1 and Movement Disorders
 Inflammation Antibodies  >5 publications with FIS1 and Inflammation
 Heart Failure Antibodies  >4 publications with FIS1 and Heart Failure
 Necrosis Antibodies  >4 publications with FIS1 and Necrosis
 Diabetes Mellitus Antibodies  >3 publications with FIS1 and Diabetes Mellitus
 Hypertrophy Antibodies  >3 publications with FIS1 and Hypertrophy
 Weight Loss Antibodies  >3 publications with FIS1 and Weight Loss

Organs/Tissues associated with FIS1 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >28 publications with FIS1 and Muscle
 Brain Antibodies  >27 publications with FIS1 and Brain
 Heart Antibodies  >17 publications with FIS1 and Heart
 Blood Antibodies  >9 publications with FIS1 and Blood
 Vascular Antibodies  >8 publications with FIS1 and Vascular
 Lung Antibodies  >7 publications with FIS1 and Lung
 Liver Antibodies  >6 publications with FIS1 and Liver
 Pancreas Antibodies  >3 publications with FIS1 and Pancreas
 Prostate Antibodies  >3 publications with FIS1 and Prostate
 Adipose Tissue Antibodies  >3 publications with FIS1 and Adipose Tissue
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