Human FKBP6 Active Protein – Cat# MBS143985

FK506 Binding Protein 6 (FKBP6) Human Active Protein

Name: FKBP6 Active Protein; FK506 Binding Protein 6; Human; MyBioSource
Brand: MyBioSource
SKU: MBS143985
Price: 250 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS143985

Description: FKBP6 Human Recombinant produced in E Coli is a single, non-glycosylated, polypeptide chain containing 347 amino acids (1-327 a.a.) and having a molecular mass of 39.3 kDa. FKBP6 protein is fused to a 20 amino acid His tag at N-terminus and is… More details

$250 / 0.002 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

FK506 Binding Protein 6 (FKBP6), Active Protein

Full Product Name

Recombinant Human FK506 Binding Protein 6

Product Gene Name

FKBP6 active protein

Product Synonym Names

FKBP6 Human; FK506 Binding Protein 6 Human Recombinant; FKBP36; EC 5.2.1.8; FKBP-6; PPIase; MGC87179; FK506-binding protein 6; Rotamase

Sequence

MGSSHHH HHH SSGLVPRGSH MGGSALNQGV LEGDDAPGQS LYERLSQRML DISGDRGVLK DVIREGAGDL VAPDASVLVK YSGYLEHMDR PFDSNYFRKT PRLMKLGEDI TLWGMELGLL SMRRGELARF LFKPNYAYGT LGCPPLIPPN TTVLFEIELL DFLDCAESDK FCALSAEQQD QFPLQKVLKV AATEREFGNY LFRQNRFYDA KVRYKRALLL LRRRSAPPEE QHLVEAAKLP VLLNLSFTYL KLDRPTIALC YGEQALIIDQ KNAKALFRCG QACLLLTEYQ KARDFLVRAQ KEQPFNHDIN NELKKLASCY RDYVDKEKEM WHRMFAPCGD GSTAGES

Form/Format

FKBP6 Human solution containing 20mM Trsi HCL pH-8, 1mM DTT, 1mM EDTA, 50mM NaCl & 40% glycerol.
Sterile filtered colorless solution.

Purity/Purification

Greater than 95% as determined by SDS-PAGE.

Preparation and Storage

FKBP6 Human although stable at 4 degree C for 1 week, should be stored desiccated below -18 degree C. Please prevent freeze thaw cycles.

Molecular Weight

33,553 Da

OMIM

604839

3D Structure

ModBase 3D Structure for O75344

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Biological Activity

Specific activity is > 190 nmoles/min/mg, and is defined as the amount of enzyme that cleaves 1umole of suc-AAFP-pNA per minute at 25C in Tris-Hcl pH8.0 using chymotrypsin.

Product Categories/Family for FKBP6 active protein

Enzymes; FK506 Binding Protein

Other Notes

Small volumes of FKBP6 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for FKBP6 purchase

MBS143985 is an active protein targeting FKBP6. Also known as Recombinant Human FK506 Binding Protein 6.

Additional Details

NCBI/Uniprot data below describe general gene information for FKBP6. It may not necessarily be applicable to this product.

NCBI GI #

206725544

NCBI GeneID

8468

NCBI Accession #

NP_001128683.1

UniProt Primary Accession #

O75344

UniProt Secondary Accession #

Q7Z4T4; Q9UDS0; B4DXT7; G3V0I2

UniProt Related Accession #

O75344

GenBank Nucleotide #

NM_001135211.2

NCBI Official Full Name

inactive peptidyl-prolyl cis-trans isomerase FKBP6 isoform b

NCBI Official Synonym Full Names

FK506 binding protein 6, 36kDa

NCBI Official Symbol

FKBP6

NCBI Official Synonym Symbols

FKBP36

UniProt Protein Name

Inactive peptidyl-prolyl cis-trans isomerase FKBP6

UniProt Synonym Protein Names

36 kDa FK506-binding protein; 36 kDa FKBP; FKBP-36; FK506-binding protein 6; FKBP-6; Immunophilin FKBP36

Protein Family

FK506-binding protein

UniProt Gene Name

FKBP6

UniProt Synonym Gene Names

FKBP36; Inactive PPIase FKBP6; 36 kDa FKBP; FKBP-36; FKBP-6

UniProt Entry Name

FKBP6_HUMAN

NCBI Protein Information

inactive peptidyl-prolyl cis-trans isomerase FKBP6; 36 kDa FKBP; PPIase FKBP6; immunophilin FKBP36; inactive PPIase FKBP6; rotamase

NCBI Summary for FKBP6

The protein encoded by this gene is a cis-trans peptidyl-prolyl isomerase that may function in immunoregulation and basic cellular processes involving protein folding and trafficking. This gene is located in a chromosomal region that is deleted in Williams-Beuren syndrome. Defects in this gene may cause male infertility. There are multiple pseudogenes for this gene located nearby on chromosome 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

UniProt Comments for FKBP6

FKBP6: PPIases accelerate the folding of proteins. FKBP6 is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region. Haploinsufficiency of FKBP6 may be the cause of certain cardiovascular and musculo-skeletal abnormalities observed in the disease. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 5.2.1.8; Isomerase

Chromosomal Location of Human Ortholog: 7q11.23

Cellular Component: endoplasmic reticulum membrane; cytoplasm; synaptonemal complex; cytosol

Molecular Function: protein binding; FK506 binding; peptidyl-prolyl cis-trans isomerase activity; Hsp90 protein binding

Biological Process: meiosis; protein peptidyl-prolyl isomerization; protein folding; DNA methylation during gametogenesis; RNA-mediated gene silencing; spermatogenesis; cell differentiation

Research Articles on FKBP6

1. Genome wide DNA methylation assessment approach identified novel biomarkers that differentiate between cervical cancer and normal samples. In the Validation cohort FKBP6 promoter methylation had 73% sensitivity and 80% specificity (AUC = 0.80).

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with FKBP6 active protein

Reference Product	PubMed Publications
GAPDH active protein	>1 publications with FKBP6 and GAPDH

Pathways associated with FKBP6 active protein

Products by Pathway	Pathway Diagram
Cell Cycle Pathway antibodies	Cell Cycle Pathway Diagram
Gene Expression Pathway antibodies	Gene Expression Pathway Diagram
Meiosis Pathway antibodies	Meiosis Pathway Diagram
Meiotic Synapsis Pathway antibodies	Meiotic Synapsis Pathway Diagram
PIWI-interacting RNA (piRNA) Biogenesis Pathway antibodies	PIWI-interacting RNA (piRNA) Biogenesis Pathway Diagram
Regulatory RNA Pathways antibodies	Regulatory RNA Pathways Diagram

Diseases associated with FKBP6 active protein

Disease Name	Pubmed Publications
Infertility, Male Antibodies	>11 publications with FKBP6 and Infertility, Male
Cardiovascular Diseases Antibodies	>9 publications with FKBP6 and Cardiovascular Diseases
Congenital Abnormalities Antibodies	>9 publications with FKBP6 and Congenital Abnormalities
Infertility, Female Antibodies	>2 publications with FKBP6 and Infertility, Female
Myocardial Ischemia Antibodies	>1 publications with FKBP6 and Myocardial Ischemia
Neoplasms, Experimental Antibodies	>1 publications with FKBP6 and Neoplasms, Experimental
Uterine Diseases Antibodies	>1 publications with FKBP6 and Uterine Diseases
Heart Defects, Congenital Antibodies	>1 publications with FKBP6 and Heart Defects, Congenital
Uterine Cervical Neoplasms Antibodies	>1 publications with FKBP6 and Uterine Cervical Neoplasms

Organs/Tissues associated with FKBP6 active protein

Organ/Tissue Name	Pubmed Publications
Testis Antibodies	>10 publications with FKBP6 and Testis
Brain Antibodies	>2 publications with FKBP6 and Brain
Ovary Antibodies	>1 publications with FKBP6 and Ovary
Lung Antibodies	>1 publications with FKBP6 and Lung