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Non-T-Cell Activation Linker (NTAL) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS144024

Description: NTAL Human Recombinant produced in E Coli is a single, non-glycosylated, polypeptide chain containing 238 amino acids (27-243 a.a.) and having a molecular mass of 26.2 kDa. NTAL protein is fused to a 21 amino acid His tag at N-terminus and is… More details

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Product Overview

Online Datasheet in PDF
Product Name
Non-T-cell Activation Linker (NTAL), Recombinant Protein
Full Product Name
Recombinant Human Non-T-cell Activation Linker
Product Gene Name
Product Synonym Names
NTAL Human; Non-T-cell Activation Linker Human Recombinant; LAT2; Linker for Activation of T CellsFamily Member 2; HSPC046; LAB; WBSCR15; WBSCR5; WSCR5; Non-T-cell activation linker; Linker for activation of B-cells; Membrane-associated adapter molecule; Williams-Beuren syndrome chromosomal region 5 protein; Williams-Beuren syndrome chromosomal region 15 protein
Sequence
MGSSHHH HHH SSGLVPRGSH MRCSRP GAKR SEKIYQQRSL REDQQSFTGS RTYSLVGQAW PGPLADMAPT RKDKLLQFYP SLEDPASSRY QNFSKGSRHG SEEAYIDPIA MEYYNWGRFS KPPEDDDANS YENVLICKQK TTETGAQQEG IGGLCRGDLS LSLALKTGPT SGLCPSASPE EDEESEDYQN SASIHQWRES RKVMGQLQRE ASPGPVGSPD EEDGEPDYVN GEVAATEA
Host
E Coli
Form/Format
NTAL Human solution containing 20mM Trsi HCL pH-8, & 10% glycerol.
Sterile filtered colorless solution.
Purity/Purification
Greater than 80% as determined by SDS-PAGE.
Preparation and Storage
NTAL Human although stable at 4 degree C for 1 week, should be stored desiccated below -18 degree C. Please prevent freeze thaw cycles.
Molecular Weight
12,255 Da
OMIM
605719
3D Structure
ModBase 3D Structure for Q9GZY6

Other Notes

Small volumes of NTAL recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for NTAL purchase

MBS144024 is a recombinant protein targeting NTAL. Also known as Recombinant Human Non-T-cell Activation Linker. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for NTAL. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
linker for activation of T-cells family member 2
NCBI Official Synonym Full Names
linker for activation of T cells family, member 2
NCBI Official Symbol
LAT2
NCBI Official Synonym Symbols
LAB; NTAL; WSCR5; WBSCR5; HSPC046; WBSCR15
UniProt Protein Name
Linker for activation of T-cells family member 2
UniProt Synonym Protein Names
Linker for activation of B-cells; Membrane-associated adapter molecule; Non-T-cell activation linker; Williams-Beuren syndrome chromosomal region 15 protein; Williams-Beuren syndrome chromosomal region 5 protein
UniProt Gene Name
LAT2
UniProt Synonym Gene Names
LAB; NTAL; WBS15; WBSCR15; WBSCR5
UniProt Entry Name
NTAL_HUMAN
NCBI Protein Information
linker for activation of T-cells family member 2; Williams-Beuren syndrome chromosomal region 15 protein; Williams-Beuren syndrome chromosomal region 5 protein; linker for activation of B-cells; linker for activation of T cells, transmembrane adaptor 2; membrane-associated adapter molecule; non-T-cell activation linker

NCBI Summary for NTAL

This gene is one of the contiguous genes at 7q11.23 commonly deleted in Williams syndrome, a multisystem developmental disorder. This gene consists of at least 14 exons, and its alternative splicing generates 3 transcript variants, all encoding the same protein. [provided by RefSeq, Jul 2008]

UniProt Comments for NTAL

LAB: linker for activation of B cells (LAB) is an adaptor protein. B cell antigen receptor signaling leads to its phosphorylation and interaction with the adaptor protein Grb2. Decreased expression leads to a reduction in BCR-mediated calcium flux and Erk activation. Localized to lipid rafts.

Protein type: Adaptor/scaffold; Membrane protein, integral

Chromosomal Location of Human Ortholog: 7q11.23

Cellular Component: mast cell granule; integral to membrane; plasma membrane; lipid raft

Molecular Function: protein binding; SH2 domain binding

Biological Process: B cell receptor signaling pathway; B cell activation; calcium-mediated signaling; innate immune response; mast cell degranulation
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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