Human PPIL2 Active Protein – Cat# MBS144027

Peptidylprolyl Isomerase (PPIL2) Human Active Protein

Name: PPIL2 Active Protein; Peptidylprolyl Isomerase; Human; MyBioSource
Brand: MyBioSource
SKU: MBS144027
Price: 250 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS144027

Description: PPIL2 Human Recombinant fused to 20 amino acid His Tag at N-terminal produced in E Coli is a single, non-glycosylated, polypeptide chain containing 547 amino acids (1-527 a.a.) and having a molecular mass of 61.6 kDa. The PPIL2 is purified by… More details

$250 / 0.002 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Peptidylprolyl Isomerase (PPIL2), Active Protein

Full Product Name

Recombinant Human Peptidylprolyl Isomerase (Cyclophilin)-Like 2

Product Gene Name

PPIL2 active protein

Product Synonym Names

PPIL2 Human; Cyclophilin-60 Human Recombinant; CYC4; Cyp-60; CYP60; hCyP-60; Peptidyl-prolyl cis-trans isomerase-like 2; PPIase; Rotamase PPIL2; Cyclophilin-60; Cyclophilin-like protein Cyp-60; PPIL2; MGC787; FLJ39930; MGC33174

Sequence

MGSSHHH HHH SSGLVPRGSH MGKRQHQKDK MYITCAEYTH FYGGKKPDLP QTNFRRLPFD HCSLSLQPFV YPVCTPDGIV FDLLNIVPWL KKYGTNPSNG EKLDGRSLIK LNFSKNSEGK YHCPVLFTVF TNNTHIVAVR TTGNVYAYEA VEQLNIKAKN FRDLLTDEPF SRQDIITLQD PTNLDKFNVS NFYHVKNNMK IIDPDEEKAK QDPSYYLKNT NAETRETLQE YKEFKGDEI LAATMKAPEK KKVDKLNAAH YSTGKVSASF TSTAMVPETT EAAAIDEDV LRYQFVKKKG YVRLHTNKGD LNLELHCDLT PKTCENFIRL CKKHYYDGTI FHRSIRNFVI QGGDPTGTGT GGESYWGKPF KDEFRPNLSH TGRGILSMAN SGPNSNRSQF FITFRSCAYL DKKHTIFGRV VGGFDVLTAM ENVESDPKTD RPKEEIRIDA TTVFVDPYEE ADAQIAQERK TQLKVAPETK VKSSQPQAGS QGPQTFRQGV GKYINPAATE QQRKSPQPVP LSPCPRRSPV GVLGTSAPGS SRLPDDH

Host

E Coli

Form/Format

The PPIL2 solution contains 20mM Tris-HCl pH-8, 0.1M NaCl and 20% glycerol.
Sterile Filtered clear colorless solution.

Purity/Purification

Greater than 95% as determined by SDS-PAGE.

Preparation and Storage

PPIL2 Recombinant Human although stable at 4 degree C for 30 days, should be stored desiccated below -20 degree C for periods greater than 30 days. Please avoid freeze-thaw cycles.

Molecular Weight

59,458 Da

OMIM

607588

3D Structure

ModBase 3D Structure for Q13356

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Biological Activity

Specific activity is > 290 nmoles/min/mg, and is defined as the amount of enzyme that cleaves 1umole of suc-AAFP-pNA per minute at 25C in Tris-Hcl pH8.0 using chymotrypsin.

Product Categories/Family for PPIL2 active protein

Enzymes; Cyclophilin

Other Notes

Small volumes of PPIL2 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PPIL2 purchase

MBS144027 is an active protein targeting PPIL2. Also known as Recombinant Human Peptidylprolyl Isomerase (Cyclophilin)-Like 2. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for PPIL2. It may not necessarily be applicable to this product.

NCBI GI #

7657473

NCBI GeneID

23759

NCBI Accession #

NP_055152.1

UniProt Primary Accession #

Q13356

UniProt Secondary Accession #

Q13357; Q8TAH2; Q9BWR8

UniProt Related Accession #

Q13356

GenBank Nucleotide #

NM_014337.3

NCBI Official Full Name

peptidyl-prolyl cis-trans isomerase-like 2 isoform a

NCBI Official Synonym Full Names

peptidylprolyl isomerase (cyclophilin)-like 2

NCBI Official Symbol

PPIL2

NCBI Official Synonym Symbols

CYC4; CYP60; UBOX7; Cyp-60; hCyP-60

UniProt Protein Name

Peptidyl-prolyl cis-trans isomerase-like 2

UniProt Synonym Protein Names

CYC4; Cyclophilin-60

Protein Family

Peptidyl-prolyl cis-trans isomerase

UniProt Gene Name

PPIL2

UniProt Synonym Gene Names

PPIaseCurated

UniProt Entry Name

PPIL2_HUMAN

NCBI Protein Information

peptidyl-prolyl cis-trans isomerase-like 2; PPIase; U-box domain containing 7; cyclophilin, 60kDa; cyclophilin-60; cyclophilin-like protein CyP-60; peptidylprolyl cis-trans isomerase; rotamase PPIL2

NCBI Summary for PPIL2

This gene is a member of the cyclophilin family of peptidylprolyl isomerases. The cyclophilins are a highly conserved ubiquitous family, members of which play an important role in protein folding, immunosuppression by cyclosporin A, and infection of HIV-1 virions. This protein interacts with the proteinase inhibitor eglin c and is localized in the nucleus. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

UniProt Comments for PPIL2

PPIL2: a peptidylprolyl isomerase (PPIase) of the cyclophilin-type family. PPIases accelerate the folding of proteins by catalyzing the cis-trans isomerization of proline imidic peptide bonds. Two alternatively-spliced isoforms have been described.

Protein type: Ligase; Cyclophilin; Ubiquitin conjugating system; EC 5.2.1.8; Spliceosome; Ubiquitin ligase; Isomerase

Chromosomal Location of Human Ortholog: 22q11.21

Cellular Component: nucleoplasm; Golgi lumen; cytoplasm; plasma membrane; nucleus

Molecular Function: protein binding; peptidyl-prolyl cis-trans isomerase activity; ligase activity

Biological Process: protein polyubiquitination; protein peptidyl-prolyl isomerization; protein folding; blood coagulation; leukocyte migration

Research Articles on PPIL2

1. common genetic variation in the BACE1-interacting proteins, RTN3 an PPIL2, does not influence platelet b-secretase activity or susceptibility to Alzheimer's disease in this population.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with PPIL2 active protein

Reference Product	PubMed Publications
BSG active protein	>1 publications with PPIL2 and BSG

Pathways associated with PPIL2 active protein

Products by Pathway	Pathway Diagram
Basigin Interactions Pathway antibodies	Basigin Interactions Pathway Diagram
Cell Surface Interactions At The Vascular Wall Pathway antibodies	Cell Surface Interactions At The Vascular Wall Pathway Diagram
Hemostasis Pathway antibodies	Hemostasis Pathway Diagram
Ubiquitin Mediated Proteolysis Pathway antibodies	Ubiquitin Mediated Proteolysis Pathway Diagram
Ubiquitin Mediated Proteolysis Pathway antibodies	Ubiquitin Mediated Proteolysis Pathway Diagram

Diseases associated with PPIL2 active protein

Disease Name	Pubmed Publications
Liver Diseases Antibodies	>1 publications with PPIL2 and Liver Diseases

Organs/Tissues associated with PPIL2 active protein

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>2 publications with PPIL2 and Blood
Nerve Antibodies	>1 publications with PPIL2 and Nerve
Thymus Antibodies	>1 publications with PPIL2 and Thymus
Kidney Antibodies	>1 publications with PPIL2 and Kidney
Pancreas Antibodies	>1 publications with PPIL2 and Pancreas
Testis Antibodies	>1 publications with PPIL2 and Testis
Brain Antibodies	>1 publications with PPIL2 and Brain