Human SUB1 Recombinant Protein – Cat# MBS144059

SUB1 Homolog (SUB1) Human Recombinant Protein

Name: SUB1 Recombinant Protein; SUB1 Homolog; Human; MyBioSource
Brand: MyBioSource
SKU: MBS144059
Price: 250 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS144059

Description: SUB1 Human Recombinant produced in E Coli is a single, non-glycosylated, polypeptide chain containing 147 amino acids (1-127 a.a.) and having a molecular mass of 16.5 kDa. SUB1 protein is fused to a 20 amino acid His tag at N-terminus and is… More details

$250 / 0.002 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

SUB1 Homolog, Recombinant Protein

Full Product Name

Recombinant Human SUB1 Homolog

Product Gene Name

SUB1 recombinant protein

Product Synonym Names

SUB1 Human; SUB1 Homolog Human Recombinant; p14; P15; PC4; Positive cofactor 4; SUB1 homolog; RPO2TC1; Activated RNA polymerase II transcriptional coactivator p15; MGC102747

Sequence

MGSSHHH HHH SSGLVPRGSH MPKSKELVSS SSSGSDSDSE VDKKLKRKKQ VAPEKPVKKQ KTGETSRALS SSKQSSSSRD DNMFQIGKMR YVSVRDFKGK VLIDIREYWM DPEGEMKPGR KGISLNPEQW SQLKEQISDI DDAVRKL

Host

E Coli

Form/Format

SUB1 Human solution containing 20mM Tris-HCl pH-8, 0.2M NaCl, 5mM DTT & 20% glycerol.
Sterile filtered colorless solution.

Purity/Purification

Greater than 90% as determined by SDS-PAGE.

Molecular Weight

14,395 Da

OMIM

600503

3D Structure

ModBase 3D Structure for P53999

Product Categories/Family for SUB1 recombinant protein

Recombinant & Natural Proteins; Recombinant Proteins

Other Notes

Small volumes of SUB1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SUB1 purchase

MBS144059 is a recombinant protein targeting SUB1. Also known as Recombinant Human SUB1 Homolog. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for SUB1. It may not necessarily be applicable to this product.

NCBI GI #

217330646

NCBI GeneID

10923

NCBI Accession #

NP_006704.3

UniProt Primary Accession #

P53999

UniProt Secondary Accession #

Q96L29

UniProt Related Accession #

P53999

GenBank Nucleotide #

NM_006713.3

NCBI Official Full Name

activated RNA polymerase II transcriptional coactivator p15

NCBI Official Synonym Full Names

SUB1 homolog (S. cerevisiae)

NCBI Official Symbol

SUB1

NCBI Official Synonym Symbols

P15; PC4; p14

UniProt Protein Name

Activated RNA polymerase II transcriptional coactivator p15

UniProt Synonym Protein Names

Positive cofactor 4; PC4; SUB1 homolog; p14

Protein Family

Activated RNA polymerase II transcriptional coactivator

UniProt Gene Name

SUB1

UniProt Synonym Gene Names

PC4; RPO2TC1; PC4

UniProt Entry Name

TCP4_HUMAN

NCBI Protein Information

activated RNA polymerase II transcriptional coactivator p15; activated RNA polymerase II transcription cofactor 4; positive cofactor 4

UniProt Comments for SUB1

PC4: a transcriptional coactivator that functions cooperatively with TAFs and mediates functional interactions between upstream activators and the general transcriptional machinery. May be involved in stabilizing the multiprotein transcription complex. Binds single-stranded DNA. Also binds, in vitro, nonspecifically to double-stranded DNA (ds DNA). Interacts with CSTF2. Its activity is controlled by phosphorylation of the regulatory domain. Phosphorylation inactivates both dsDNA-binding and cofactor function. Seems to be phosphorylated in vivo by CK2 in at least 7 sites in the N-terminal Ser-rich region.

Protein type: DNA-binding; Transcription, coactivator/corepressor; Nuclear receptor co-regulator

Chromosomal Location of Human Ortholog: 5p13.3

Cellular Component: transcription factor complex; nucleolus; nucleus

Molecular Function: protein binding; transcription coactivator activity; single-stranded DNA binding

Biological Process: regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter

Research Articles on SUB1

1. p38 MAP kinase mediated HNF4 Ser158 phosphorylation (P-HNF4-S158), binding of PC4 to P-HNF4-S158 and characterize the functional domain of PC4 required for P-HNF4-S158 binding.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with SUB1 recombinant protein

Reference Product	PubMed Publications
TP53 recombinant protein	>1 publications with SUB1 and TP53

Diseases associated with SUB1 recombinant protein

Disease Name	Pubmed Publications
Carcinoma Antibodies	>5 publications with SUB1 and Carcinoma
Breast Neoplasms Antibodies	>4 publications with SUB1 and Breast Neoplasms
Lung Neoplasms Antibodies	>3 publications with SUB1 and Lung Neoplasms
Uterine Cervical Neoplasms Antibodies	>1 publications with SUB1 and Uterine Cervical Neoplasms
Inflammation Antibodies	>1 publications with SUB1 and Inflammation
Nervous System Diseases Antibodies	>1 publications with SUB1 and Nervous System Diseases
Ovarian Neoplasms Antibodies	>1 publications with SUB1 and Ovarian Neoplasms
Neoplasm Metastasis Antibodies	>1 publications with SUB1 and Neoplasm Metastasis
Adenocarcinoma Antibodies	>1 publications with SUB1 and Adenocarcinoma
Neurobehavioral Manifestations Antibodies	>1 publications with SUB1 and Neurobehavioral Manifestations

Organs/Tissues associated with SUB1 recombinant protein

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>12 publications with SUB1 and Blood
Brain Antibodies	>4 publications with SUB1 and Brain
Lung Antibodies	>3 publications with SUB1 and Lung
Muscle Antibodies	>3 publications with SUB1 and Muscle
Thyroid Antibodies	>3 publications with SUB1 and Thyroid
Liver Antibodies	>2 publications with SUB1 and Liver
Vascular Antibodies	>2 publications with SUB1 and Vascular
Eye Antibodies	>1 publications with SUB1 and Eye
Skin Antibodies	>1 publications with SUB1 and Skin
Prostate Antibodies	>1 publications with SUB1 and Prostate