Transcription Initiation Factor TFIID Subunit 11 (TAF11) Human Recombinant Protein

Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes a small subunit of TFIID that is present in all TFIID complexes and interacts with TBP. This subunit also interacts with another small subunit, TAF13, to form a heterodimer with a structure similar to the histone core structure. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2012]

TAF11: a TBP-associated factor (TAF). A component of TFIID complexes composed of the TATA binding protein (TBP), TAF13 and TAF11. TAF10 and TAF13 contain non-canonical histone folds, forming a histone-like pair in TFIID complexes.

Protein type: DNA-binding; Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: 6p21.31

Cellular Component: nucleoplasm; Golgi apparatus; transcription factor TFIID complex

Molecular Function: protein binding; DNA binding; vitamin D receptor binding; protein heterodimerization activity; transcription coactivator activity; protein N-terminus binding; thyroid hormone receptor binding

Biological Process: transcription from RNA polymerase II promoter; transcription initiation from RNA polymerase II promoter; regulation of transcription, DNA-dependent; viral reproduction; RNA elongation from RNA polymerase II promoter; gene expression