Human QPRT Recombinant Protein – Cat# MBS144110

Quinolinate Phosphoribosyltransferase (QPRT) Human Recombinant Protein

Name: QPRT Recombinant Protein; Human; MyBioSource
Brand: MyBioSource
SKU: MBS144110
Price: 250 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS144110

QPRT Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 317 amino acids (1-297 a.a.) and having a molecular mass of 32.9 kDa. The QPRT is fused to a 20 amino acid His-Tag at N-terminus and purified by proprietary… More details

$250 / 0.005 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Quinolinate Phosphoribosyltransferase (QPRT), Recombinant Protein

Full Product Name

Recombinant Human Quinolinate Phosphoribosyltransferase

Product Gene Name

QPRT recombinant protein

Product Synonym Names

QPRT Human; Quinolinate Phosphoribosyltransferase Human Recombinant; Quinolinate phosphoribosyltransferase; QPRTase; QAPRTase

Sequence

MGSSHHH HHH SSGLVPRGSH MDAEGLALLL PPVTLAALVD SWLREDCPGL NYAALVSGAG PSQAALWAKS PGVLAGQPFF DAIFTQLNCQ VSWFLPEGSK LVPVARVAEV RGPAHCLLLG ERVALNTLAR CSGIASAAAA AVEAARGAGW TGHVAGTRKT TPGFRLVEKY GLLVGGAASH RYDLGGLVMV KDNHVVAAGG VEKAVRAARQ AADFALKVEV ECSSLQEAVQ AAEAGADLVL LDNFKPEELH PTATVLKAQF PSVAVEASGG ITLDNLPQFC GPHIDVISMG MLTQAAPALD FSLKLFAKEV APVPKIH

Host

E. coli

Form/Format

The QPRT solution (1mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 1mM DTT and 10% glycerol.

Purity/Purification

Greater than 95.0% as determined by SDS-PAGE.

Preparation and Storage

Store at 4°C if entire vial will be used within 2-4 weeks.
Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Avoid multiple freeze-thaw cycles.

OMIM

606248

3D Structure

ModBase 3D Structure for Q15274

Physical Appearance

Sterile Filtered colorless solution.

Product Categories/Family for QPRT recombinant protein

Enzymes; Transferase

Other Notes

Small volumes of QPRT recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for QPRT purchase

MBS144110 is a recombinant protein targeting QPRT. Also known as Recombinant Human Quinolinate Phosphoribosyltransferase. Host: E. coli.

Additional Details

NCBI/Uniprot data below describe general gene information for QPRT. It may not necessarily be applicable to this product.

NCBI GI #

45269149

NCBI GeneID

23475

NCBI Accession #

NP_055113.2

UniProt Primary Accession #

Q15274

UniProt Secondary Accession #

Q53XW7; Q96G22; Q9BSG6

UniProt Related Accession #

Q15274

GenBank Nucleotide #

NM_014298.3

NCBI Official Full Name

nicotinate-nucleotide pyrophosphorylase

NCBI Official Synonym Full Names

quinolinate phosphoribosyltransferase

NCBI Official Symbol

QPRT

NCBI Official Synonym Symbols

QPRTase; HEL-S-90n

UniProt Protein Name

Nicotinate-nucleotide pyrophosphorylase [carboxylating]

UniProt Synonym Protein Names

Quinolinate phosphoribosyltransferase [decarboxylating]; QAPRTase; QPRTase

Protein Family

Nicotinate-nucleotide pyrophosphorylase

UniProt Gene Name

QPRT

UniProt Synonym Gene Names

QAPRTase; QPRTase

UniProt Entry Name

NADC_HUMAN

NCBI Protein Information

nicotinate-nucleotide pyrophosphorylase [carboxylating]; nicotinate-nucleotide pyrophosphorylase [carboxylating]; QAPRTase; epididymis secretory sperm binding protein Li 90n; nicotinate-nucleotide pyrophosphorylase (carboxylating)

NCBI Summary for QPRT

This gene encodes a key enzyme in catabolism of quinolinate, an intermediate in the tryptophan-nicotinamide adenine dinucleotide pathway. Quinolinate acts as a most potent endogenous exitotoxin to neurons. Elevation of quinolinate levels in the brain has been linked to the pathogenesis of neurodegenerative disorders such as epilepsy, Alzheimer's disease, and Huntington's disease. [provided by RefSeq, Jul 2008]

UniProt Comments for QPRT

QPRT: Involved in the catabolism of quinolinic acid (QA). Belongs to the NadC/ModD family.

Protein type: Transferase; Cofactor and Vitamin Metabolism - nicotinate and nicotinamide; EC 2.4.2.19

Chromosomal Location of Human Ortholog: 16p11.2

Cellular Component: cytoplasm; cytosol

Molecular Function: protein homodimerization activity; nicotinate-nucleotide diphosphorylase (carboxylating) activity

Biological Process: NAD biosynthetic process; vitamin metabolic process; NAD metabolic process; water-soluble vitamin metabolic process; protein oligomerization

Research Articles on QPRT

1. Report of the crystal structure of human QPRT bound to its inhibitor phthalic acid (PHT) and kinetic analysis of PHT inhibition of human QPRT.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with QPRT recombinant protein

Products by Pathway	Pathway Diagram
Defective AMN Causes Hereditary Megaloblastic Anemia 1 Pathway antibodies	Defective AMN Causes Hereditary Megaloblastic Anemia 1 Pathway Diagram
Defective BTD Causes Biotidinase Deficiency Pathway antibodies	Defective BTD Causes Biotidinase Deficiency Pathway Diagram
Defective CD320 Causes Methylmalonic Aciduria Pathway antibodies	Defective CD320 Causes Methylmalonic Aciduria Pathway Diagram
Defective CUBN Causes Hereditary Megaloblastic Anemia 1 Pathway antibodies	Defective CUBN Causes Hereditary Megaloblastic Anemia 1 Pathway Diagram
Defective GIF Causes Intrinsic Factor Deficiency Pathway antibodies	Defective GIF Causes Intrinsic Factor Deficiency Pathway Diagram
Defective HLCS Causes Multiple Carboxylase Deficiency Pathway antibodies	Defective HLCS Causes Multiple Carboxylase Deficiency Pathway Diagram
Defective LMBRD1 Causes Methylmalonic Aciduria And Homocystinuria Type CblF Pathway antibodies	Defective LMBRD1 Causes Methylmalonic Aciduria And Homocystinuria Type CblF Pathway Diagram
Defective MMAA Causes Methylmalonic Aciduria Type CblA Pathway antibodies	Defective MMAA Causes Methylmalonic Aciduria Type CblA Pathway Diagram
Defective MMAB Causes Methylmalonic Aciduria Type CblB Pathway antibodies	Defective MMAB Causes Methylmalonic Aciduria Type CblB Pathway Diagram
Defective MMACHC Causes Methylmalonic Aciduria And Homocystinuria Type CblC Pathway antibodies	Defective MMACHC Causes Methylmalonic Aciduria And Homocystinuria Type CblC Pathway Diagram

Diseases associated with QPRT recombinant protein

Disease Name	Pubmed Publications
Nervous System Diseases Antibodies	>3 publications with QPRT and Nervous System Diseases
Cognition Disorders Antibodies	>2 publications with QPRT and Cognition Disorders
Nerve Degeneration Antibodies	>1 publications with QPRT and Nerve Degeneration
Carcinoma Antibodies	>1 publications with QPRT and Carcinoma
Kidney Diseases Antibodies	>1 publications with QPRT and Kidney Diseases
Cell Transformation, Neoplastic Antibodies	>1 publications with QPRT and Cell Transformation, Neoplastic
Inflammation Antibodies	>1 publications with QPRT and Inflammation

Organs/Tissues associated with QPRT recombinant protein

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>14 publications with QPRT and Brain
Liver Antibodies	>9 publications with QPRT and Liver
Blood Antibodies	>4 publications with QPRT and Blood
Kidney Antibodies	>4 publications with QPRT and Kidney