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Typhimurium Uridine Phosphorylase (UPP1) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS144116

Description: UPP1 Human Recombinant protein produced in E Coli is a single, non-glycosylated, polypeptide chain containing 330 amino acids (1-310) and having a molecular mass of 29.3 kDa. UPP1 is fused to 20 amino acid His Tag at N-terminus and is purified by… More details

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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
Typhimurium Uridine phosphorylase (UPP1), Recombinant Protein
Full Product Name
Recombinant Human Typhimurium Uridine phosphorylase
Product Gene Name
UPP1 recombinant protein
Product Synonym Names
UPP1 Human; Uridine Phosphorylase 1 Human Recombinant; UP; UPASE; UPP; UrdPase 1
Sequence
MGSSHHH HHH SSGLVPRGSH MAATGA NAEK AESHNDCPVR LLNPNIAKMK EDILYHFNLT TSRHNFPALF GDVKFVCVGG SPSRMKAFIR CVGAELGLDC PGRDYPNICA GTDRYAMYKV GPVLSVSHGM GIPSISIMLH ELIKLLYYAR CSNVTIIRIG TSGGIGLEPG TVVITEQAVD TCFKAEFEQI VLGKRVIRKT DLNKKLVQEL LLCSAELSEF TTVVGNTMCT LDFYEGQGRL DGALCSYTEK DKQAYLEAAY AAGVRNIEME SSVFAAMCSA CGLQAAVVCV TLLNRLEGDQ ISSPRNVLSE YQQRPQRLVS YFIKKKLSKA
Host
E Coli
Form/Format
UPP1 0.25mg/ml solution contains 20 mM Tris-HCl buffer (pH 8.0), 1mM DTT, 0.2M NaCl and 40% glycerol.
Sterile filtered colorless solution.
Purity/Purification
Greater than 90.0% as determined by SDS-PAGE.
Preparation and Storage
UPP1 Human Recombinant although stable at 4 degree C for 1 week, should be stored desiccated below -18 degree C. Please prevent freeze thaw cycles.
Molecular Weight
3,694 Da
OMIM
191730
3D Structure
ModBase 3D Structure for Q16831

Product Categories/Family for UPP1 recombinant protein

Enzymes; Phosphorylase

Other Notes

Small volumes of UPP1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for UPP1 purchase

MBS144116 is a recombinant protein targeting UPP1. Also known as Recombinant Human Typhimurium Uridine phosphorylase. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for UPP1. It may not necessarily be applicable to this product.

NCBI GI #
566006139
NCBI GeneID
7378
NCBI Accession #
NP_001274355.1
UniProt Primary Accession #
Q16831
UniProt Secondary Accession #
Q15362; D3DVM4
UniProt Related Accession #
Q16831
GenBank Nucleotide #
NM_001287426.1
NCBI Official Full Name
uridine phosphorylase 1 isoform a
NCBI Official Synonym Full Names
uridine phosphorylase 1
NCBI Official Symbol
UPP1
NCBI Official Synonym Symbols
UP; UPP; UPASE; UDRPASE
UniProt Protein Name
Uridine phosphorylase 1
Protein Family
Uridine phosphorylase
UniProt Gene Name
UPP1
UniProt Synonym Gene Names
UP; UPase 1; UrdPase 1
UniProt Entry Name
UPP1_HUMAN
NCBI Protein Information
uridine phosphorylase 1; UPase 1; urdPase 1

NCBI Summary for UPP1

The 2 known types of pyrimidine nucleoside phosphorylases, uridine phosphorylase (UP; EC 2.4.2.3) and thymidine phosphorylase (TP; EC 2.4.2.4), in the presence of orthophosphate, catalyze the reversible phosphorolysis of uridine and thymidine or deoxyuridine, respectively, to free bases and ribose-1-phosphate or deoxyribose-1-phosphate. Pyrimidine nucleoside phosphorylases can add ribose or deoxyribose to pyrimidine bases to form nucleosides that can be incorporated into RNA or DNA (Watanabe and Uchida, 1995 [PubMed 7488099]).[supplied by OMIM, Aug 2009]
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UniProt Comments for UPP1

UPP1: Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. Belongs to the PNP/UDP phosphorylase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Transferase; EC 2.4.2.3; Xenobiotic Metabolism - drug metabolism - other enzymes; Nucleotide Metabolism - pyrimidine

Chromosomal Location of Human Ortholog: 7p12.3

Cellular Component: cytosol

Molecular Function: uridine phosphorylase activity

Biological Process: cellular response to glucose starvation; pyrimidine nucleoside catabolic process; uridine metabolic process; pyrimidine base metabolic process; nucleobase, nucleoside and nucleotide metabolic process; nucleobase, nucleoside, nucleotide and nucleic acid metabolic process; nucleotide catabolic process; pyrimidine nucleoside salvage
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Research Articles on UPP1

1. The dimeric enzyme is capable of a large hinge motion facilitating ligand exchange.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with UPP1 recombinant protein

 Reference Product  PubMed Publications
 TYMP recombinant protein  >3 publications with UPP1 and TYMP
 DPYD recombinant protein  >1 publications with UPP1 and DPYD

Pathways associated with UPP1 recombinant protein

 Products by Pathway  Pathway Diagram
 Drug Metabolism - Other Enzymes Pathway antibodies  Drug Metabolism - Other Enzymes Pathway Diagram
 Drug Metabolism - Other Enzymes Pathway antibodies  Drug Metabolism - Other Enzymes Pathway Diagram
 Fluoropyrimidine Activity Pathway antibodies  Fluoropyrimidine Activity Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Nucleotides Pathway antibodies  Metabolism Of Nucleotides Pathway Diagram
 Pyrimidine Catabolism Pathway antibodies  Pyrimidine Catabolism Pathway Diagram
 Pyrimidine Metabolism Pathway antibodies  Pyrimidine Metabolism Pathway Diagram
 Pyrimidine Metabolism Pathway antibodies  Pyrimidine Metabolism Pathway Diagram
 Pyrimidine Metabolism Pathway antibodies  Pyrimidine Metabolism Pathway Diagram

Diseases associated with UPP1 recombinant protein

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >3 publications with UPP1 and Nervous System Diseases
 Brain Diseases Antibodies  >3 publications with UPP1 and Brain Diseases
 Mitochondrial Diseases Antibodies  >2 publications with UPP1 and Mitochondrial Diseases
 Disease Models, Animal Antibodies  >1 publications with UPP1 and Disease Models, Animal

Organs/Tissues associated with UPP1 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Ovary Antibodies  >2 publications with UPP1 and Ovary
 Liver Antibodies  >1 publications with UPP1 and Liver
 Blood Antibodies  >1 publications with UPP1 and Blood
 Brain Antibodies  >1 publications with UPP1 and Brain
 Pancreas Antibodies  >1 publications with UPP1 and Pancreas
 Lung Antibodies  >1 publications with UPP1 and Lung
 Skin Antibodies  >1 publications with UPP1 and Skin
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