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Transforming Growth Factor-Beta 3 (TGF b 3) Human Active Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS144136

Description: TGFB3 Human Recombinant produced in plant is a disulfide-linked homodimeric, glycosylated, polypeptide chain containing 118 amino acids and having a molecular mass of 27.2kDa. The TGFB3 is fused to 6xHis tag at N-terminus and purified by standard… More details

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Product Overview

Online Datasheet in PDF
Product Name
Transforming Growth Factor-Beta 3 (TGF b 3), Active Protein
Full Product Name
Recombinant Human Transforming Growth Factor-Beta 3, Plant
Product Gene Name
TGF b 3 active protein
Product Synonym Names
TGF b 3 Human, Plant; Transforming Growth Factor-Beta 3 Human Recombinant, Plant; Transforming Growth Factor-beta3; TGFB3; ARVD; FLJ16571; TGF-beta3; TGF b 3 Plant
Sequence
HHHHHALDTN YCFRNLEENC CVRPLYIDFR QDLGWKWVHE PKGYYANFCS GPCPYLRSAD TTHSTVLGLY NTLNPEASAS PCCVPQDLEP LTILYYVGRT PKVEQLSNMV VKSCKCS
Host
Nicotiana benthamiana
Form/Format
Lyophilized from a concentrated (1mg/ml) solution containing 50mM Tris-HCl pH-7.4.
Sterile Filtered White lyophilized (freeze-dried) powder.
Purity/Purification
Greater than 95.0% as determined by SDS-PAGE.
Preparation and Storage
Lyophilized TGFB3 although stable at room temperature for 3 weeks, should be stored desiccated below -18 degree C. Upon reconstitution TGFB3 Human should be stored at 4 degree C between 2-7 days and for future use below -18 degree C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
Molecular Weight
35,708 Da
OMIM
107970
3D Structure
ModBase 3D Structure for P10600
Active Protein Note
Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.
Solubility
It is recommended to reconstitute the lyophilized TGFB3 in sterile 5mM HCl & 50ug/ml BSA at a concentration of 0.05mg/ml, which can then be further diluted to other aqueous solutions.
Biological Activity
The biological activity of TGFB3 is measured in culture by its ability to inhibit the mink lung epithelial (Mv1Lu) cells proliferation. ED50 ? 40ng/ml corresponding to a specific activity of 25,000 Units/mg.

Product Categories/Family for TGF b 3 active protein

Cytokines and Growth Factors; Growth Factors; Transforming Growth Factor

Other Notes

Small volumes of TGF b 3 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TGF b 3 purchase

MBS144136 is an active protein targeting TGF b 3. Also known as Recombinant Human Transforming Growth Factor-Beta 3, Plant. Host: Nicotiana benthamiana.

Additional Details

NCBI/Uniprot data below describe general gene information for TGF b 3. It may not necessarily be applicable to this product.

NCBI GI #
4507465
NCBI GeneID
7043
NCBI Accession #
NP_003230.1
UniProt Primary Accession #
P10600
UniProt Secondary Accession #
Q8WV88
UniProt Related Accession #
P10600
GenBank Nucleotide #
NM_003239.3
NCBI Official Full Name
transforming growth factor beta-3 preproprotein
NCBI Official Synonym Full Names
transforming growth factor, beta 3
NCBI Official Symbol
TGFB3
NCBI Official Synonym Symbols
ARVD; RNHF; ARVD1; TGF-beta3
UniProt Protein Name
Transforming growth factor beta-3
Protein Family
Transforming growth factor
UniProt Gene Name
TGFB3
UniProt Synonym Gene Names
TGF-beta-3; LAP
UniProt Entry Name
TGFB3_HUMAN
NCBI Protein Information
transforming growth factor beta-3; TGF-beta-3; prepro-transforming growth factor beta-3

NCBI Summary for TGF b 3

This gene encodes a member of the TGF-beta family of proteins. The encoded protein is secreted and is involved in embryogenesis and cell differentiation. Defects in this gene are a cause of familial arrhythmogenic right ventricular dysplasia 1. [provided by RefSeq, Mar 2009]

UniProt Comments for TGF b 3

TGFB3: Involved in embryogenesis and cell differentiation. Homodimer; disulfide-linked. Interacts with ASPN. Belongs to the TGF-beta family.

Protein type: Ligand, receptor tyrosine kinase; Secreted; Motility/polarity/chemotaxis; Cell development/differentiation; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 14q24

Cellular Component: extracellular matrix; extracellular space; cell surface; cell soma; T-tubule; plasma membrane; extracellular region; nucleus

Molecular Function: identical protein binding; protein binding; growth factor activity; protein heterodimerization activity; transforming growth factor beta binding; punt binding; cytokine activity

Biological Process: extracellular matrix organization and biogenesis; activation of MAPK activity; positive regulation of apoptosis; positive regulation of transcription, DNA-dependent; positive regulation of collagen biosynthetic process; palate development; female pregnancy; SMAD protein nuclear translocation; odontogenesis; regulation of apoptosis; negative regulation of cell proliferation; platelet degranulation; mammary gland development; transforming growth factor beta receptor signaling pathway; salivary gland morphogenesis; embryonic neurocranium morphogenesis; negative regulation of neuron apoptosis; cell growth; inner ear development; aging; uterine wall breakdown; positive regulation of filopodium formation; platelet activation; intercellular junction assembly and maintenance; in utero embryonic development; positive regulation of bone mineralization; regulation of cell proliferation; gut development; positive regulation of protein secretion; response to estrogen stimulus; negative regulation of DNA replication; regulation of MAPKKK cascade; positive regulation of cell division; response to hypoxia; positive regulation of transcription from RNA polymerase II promoter; response to progesterone stimulus; blood coagulation; negative regulation of transforming growth factor beta receptor signaling pathway; alveolus development; positive regulation of DNA replication

Disease: Arrhythmogenic Right Ventricular Dysplasia, Familial, 1; Rienhoff Syndrome
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Research Articles on TGF b 3

1. Crystal structures, mutations and peptide-affinity measurements show that alpahVbeta6 binds with high affinity to a RGDLXXL/I motif within the prodomains of TGF-beta1 and TGF-beta3.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with TGF b 3 active protein

 Reference Product  PubMed Publications
 TGFB2 active protein  >575 publications with TGF b 3 and TGFB2
 EGF active protein  >22 publications with TGF b 3 and EGF
 SERPINE1 active protein  >16 publications with TGF b 3 and SERPINE1
 TGFBR2 active protein  >10 publications with TGF b 3 and TGFBR2
 TGFBR1 active protein  >9 publications with TGF b 3 and TGFBR1
 SMAD5 active protein  >2 publications with TGF b 3 and SMAD5
 TIMP1 active protein  >2 publications with TGF b 3 and TIMP1
 FN1 active protein  >2 publications with TGF b 3 and FN1
 ACVRL1 active protein  >1 publications with TGF b 3 and ACVRL1

Pathways associated with TGF b 3 active protein

 Products by Pathway  Pathway Diagram
 ALK1 Signaling Events Pathway antibodies  ALK1 Signaling Events Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Chronic Myeloid Leukemia Pathway antibodies  Chronic Myeloid Leukemia Pathway Diagram
 Chronic Myeloid Leukemia Pathway antibodies  Chronic Myeloid Leukemia Pathway Diagram
 Colorectal Cancer Pathway antibodies  Colorectal Cancer Pathway Diagram

Diseases associated with TGF b 3 active protein

 Disease Name  Pubmed Publications
 Fibrosis Antibodies  >192 publications with TGF b 3 and Fibrosis
 Cleft Palate Antibodies  >108 publications with TGF b 3 and Cleft Palate
 Disease Models, Animal Antibodies  >107 publications with TGF b 3 and Disease Models, Animal
 Cardiovascular Diseases Antibodies  >88 publications with TGF b 3 and Cardiovascular Diseases
 Inflammation Antibodies  >82 publications with TGF b 3 and Inflammation
 Necrosis Antibodies  >65 publications with TGF b 3 and Necrosis
 Heart Diseases Antibodies  >54 publications with TGF b 3 and Heart Diseases
 Breast Neoplasms Antibodies  >40 publications with TGF b 3 and Breast Neoplasms
 Lung Diseases Antibodies  >39 publications with TGF b 3 and Lung Diseases
 Hypertrophy Antibodies  >39 publications with TGF b 3 and Hypertrophy

Organs/Tissues associated with TGF b 3 active protein

 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >365 publications with TGF b 3 and Bone
 Connective Tissue Antibodies  >255 publications with TGF b 3 and Connective Tissue
 Embryonic Tissue Antibodies  >147 publications with TGF b 3 and Embryonic Tissue
 Bone Marrow Antibodies  >130 publications with TGF b 3 and Bone Marrow
 Mouth Antibodies  >122 publications with TGF b 3 and Mouth
 Heart Antibodies  >81 publications with TGF b 3 and Heart
 Lung Antibodies  >79 publications with TGF b 3 and Lung
 Eye Antibodies  >68 publications with TGF b 3 and Eye
 Brain Antibodies  >68 publications with TGF b 3 and Brain
 Liver Antibodies  >53 publications with TGF b 3 and Liver
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