Human PGAM1 Recombinant Protein – Cat# MBS144147

Phosphoglycerate Mutase 1 (PGAM1) Human Recombinant Protein

Name: PGAM1 Recombinant Protein; Phosphoglycerate Mutase 1; Human; MyBioSource
Brand: MyBioSource
SKU: MBS144147
Price: 250 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS144147

Description: PGAM1 Human Recombinant produced in E Coli is a single, non-glycosylated, polypeptide chain containing 274 amino acids (1-254 a.a.) and having a molecular mass of 30.9 kDa. The PGAM1 is fused to a 20 amino acid His Tag at N-Terminus and purified… More details

$250 / 0.005 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Phosphoglycerate Mutase 1 (PGAM1), Recombinant Protein

Full Product Name

Recombinant Human Phosphoglycerate Mutase 1

Product Gene Name

PGAM1 recombinant protein

Product Synonym Names

PGAM1 Human; Phosphoglycerate Mutase 1 Human Recombinant; Phosphoglycerate mutase isozyme B; PGAM-B; PGAMA

Sequence

MGSSHHH HHH SSGLVPRGSH MAAYKLVLIR HGESAWNLEN RFSGWYDADL SPAGHEEAKR GGQALRDAGY EFDICFTSVQ KRAIRTLWTV LDAIDQMWLP VVRTWRLNER HYGGLTGLNK AETAAKHGEA QVKIWRRSYD VPPPPMEPDH PFYSNISKDR RYADLTEDQL PSCESLKDTI ARALPFWNEE IVPQIKEGKR VLIAAHGNSL RGIVKHLEGL SEEAIMELNL PTGIPIVYEL DKNLKPIKPM QFLGDEETVR KAMEAVAAQG KAKK

Form/Format

The PGAM1 protein solution (1mg/ml) contains 20mM Tris-HCl pH-8, 1mM DTT, and 10% glycerol.

Purity/Purification

Greater than 90% as determined by SDS-PAGE.

Concentration

1mg/ml (lot specific)

Preparation and Storage

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.

OMIM

172250

3D Structure

ModBase 3D Structure for P18669

Source

E.coli

Appearance

Sterile filtered colorless solution

Product Categories/Family for PGAM1 recombinant protein

Enzymes; Mutase

Other Notes

Small volumes of PGAM1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PGAM1 purchase

MBS144147 is a recombinant protein targeting PGAM1. Also known as Recombinant Human Phosphoglycerate Mutase 1.

Additional Details

NCBI/Uniprot data below describe general gene information for PGAM1. It may not necessarily be applicable to this product.

NCBI GI #

4505753

NCBI GeneID

5223

NCBI Accession #

NP_002620.1

UniProt Primary Accession #

P18669

UniProt Secondary Accession #

Q9BWC0

UniProt Related Accession #

P18669

GenBank Nucleotide #

NM_002629.2

NCBI Official Full Name

phosphoglycerate mutase 1

NCBI Official Synonym Full Names

phosphoglycerate mutase 1 (brain)

NCBI Official Symbol

PGAM1

NCBI Official Synonym Symbols

PGAMA; PGAM-B; HEL-S-35

UniProt Protein Name

Phosphoglycerate mutase 1

UniProt Synonym Protein Names

BPG-dependent PGAM 1; Phosphoglycerate mutase isozyme B; PGAM-B

Protein Family

Phosphoglycerate mutase

UniProt Gene Name

PGAM1

UniProt Synonym Gene Names

PGAMA; PGAM-B

UniProt Entry Name

PGAM1_HUMAN

NCBI Protein Information

phosphoglycerate mutase 1; BPG-dependent PGAM 1; epididymis secretory protein Li 35; phosphoglycerate mutase A, nonmuscle form; phosphoglycerate mutase isozyme B

NCBI Summary for PGAM1

Phosphoglyceric acid mutase (EC 2.7.5.3) is widely distributed in mammalian tissues where it catalyzes the reversible reaction of 3-phosphoglycerate (3-PGA) to 2-phosphoglycerate (2-PGA) in the glycolytic pathway (summary by Chen et al., 1974 [PubMed 4811757]).[supplied by OMIM, Nov 2010]

UniProt Comments for PGAM1

PGAM1: Interconversion of 3- and 2-phosphoglycerate with 2,3- bisphosphoglycerate as the primer of the reaction. Can also catalyze the reaction of EC 5.4.2.4 (synthase) and EC 3.1.3.13 (phosphatase), but with a reduced activity. Homodimer. In mammalian tissues there are two types of phosphoglycerate mutase isozymes: type-M in muscles and type-B in other tissues. Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily.

Protein type: EC 5.4.2.11; EC 5.4.2.4; Isomerase; EC 3.1.3.13; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Phosphatase (non-protein)

Chromosomal Location of Human Ortholog: 10q25.3

Cellular Component: membrane; cytoplasm; cytosol

Molecular Function: protein binding; phosphoglycerate mutase activity; bisphosphoglycerate mutase activity; bisphosphoglycerate phosphatase activity; protein kinase binding

Biological Process: respiratory burst; glycolysis; dephosphorylation; regulation of glycolysis; carbohydrate metabolic process; glucose metabolic process; pathogenesis; regulation of pentose-phosphate shunt; gluconeogenesis

Research Articles on PGAM1

1. Tyrosine26 phosphorylation represents an additional acute mechanism underlying phosphoglycerate mutase 1 upregulation.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with PGAM1 recombinant protein

Reference Product	PubMed Publications
ENO1 recombinant protein	>7 publications with PGAM1 and ENO1
PKM2 recombinant protein	>4 publications with PGAM1 and PKM2
PGK1 recombinant protein	>4 publications with PGAM1 and PGK1
TPI1 recombinant protein	>3 publications with PGAM1 and TPI1
LDHA recombinant protein	>2 publications with PGAM1 and LDHA

Pathways associated with PGAM1 recombinant protein

Products by Pathway	Pathway Diagram
Biosynthesis Of Amino Acids Pathway antibodies	Biosynthesis Of Amino Acids Pathway Diagram
Biosynthesis Of Amino Acids Pathway antibodies	Biosynthesis Of Amino Acids Pathway Diagram
Carbon Metabolism Pathway antibodies	Carbon Metabolism Pathway Diagram
Carbon Metabolism Pathway antibodies	Carbon Metabolism Pathway Diagram
Central Carbon Metabolism In Cancer Pathway antibodies	Central Carbon Metabolism In Cancer Pathway Diagram
Central Carbon Metabolism In Cancer Pathway antibodies	Central Carbon Metabolism In Cancer Pathway Diagram
Disease Pathway antibodies	Disease Pathway Diagram
Gluconeogenesis Pathway antibodies	Gluconeogenesis Pathway Diagram
Gluconeogenesis, Oxaloacetate => Fructose-6P Pathway antibodies	Gluconeogenesis, Oxaloacetate => Fructose-6P Pathway Diagram
Gluconeogenesis, Oxaloacetate => Fructose-6P Pathway antibodies	Gluconeogenesis, Oxaloacetate => Fructose-6P Pathway Diagram

Diseases associated with PGAM1 recombinant protein

Disease Name	Pubmed Publications
Carcinoma Antibodies	>4 publications with PGAM1 and Carcinoma
Disease Models, Animal Antibodies	>3 publications with PGAM1 and Disease Models, Animal
Carcinoma, Hepatocellular Antibodies	>1 publications with PGAM1 and Carcinoma, Hepatocellular
Hepatitis Antibodies	>1 publications with PGAM1 and Hepatitis
Hyperplasia Antibodies	>1 publications with PGAM1 and Hyperplasia
Liver Neoplasms Antibodies	>1 publications with PGAM1 and Liver Neoplasms
Necrosis Antibodies	>1 publications with PGAM1 and Necrosis
Carcinoma, Non-Small-Cell Lung Antibodies	>1 publications with PGAM1 and Carcinoma, Non-Small-Cell Lung
Mammary Neoplasms, Animal Antibodies	>1 publications with PGAM1 and Mammary Neoplasms, Animal
Carcinoma, Squamous Cell Antibodies	>1 publications with PGAM1 and Carcinoma, Squamous Cell

Organs/Tissues associated with PGAM1 recombinant protein

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>13 publications with PGAM1 and Brain
Blood Antibodies	>6 publications with PGAM1 and Blood
Muscle Antibodies	>4 publications with PGAM1 and Muscle
Testis Antibodies	>3 publications with PGAM1 and Testis
Lung Antibodies	>3 publications with PGAM1 and Lung
Heart Antibodies	>3 publications with PGAM1 and Heart
Liver Antibodies	>3 publications with PGAM1 and Liver
Ovary Antibodies	>2 publications with PGAM1 and Ovary
Kidney Antibodies	>2 publications with PGAM1 and Kidney
Stomach Antibodies	>1 publications with PGAM1 and Stomach