Sorting Nexin 1 (SNX1) Human Recombinant Protein

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This endosomal protein regulates the cell-surface expression of epidermal growth factor receptor. This protein also has a role in sorting protease-activated receptor-1 from early endosomes to lysosomes. This protein may form oligomeric complexes with family members. This gene results in three transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]

SNX1: May be involved in several stages of intracellular trafficking. Plays a role in targeting ligand-activated EGFR to the lysosomes for degradation after endocytosis from the cell surface and release from the Golgi. Component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network. Interacts with membranes containing phosphatidylinositol 3- phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Belongs to the sorting nexin family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Vesicle

Chromosomal Location of Human Ortholog: 15q22.31

Cellular Component: Golgi apparatus; protein complex; extrinsic to membrane; intracellular membrane-bound organelle; membrane; retromer complex; lamellipodium; early endosome membrane; cytoplasm; endosome membrane; cytosol

Molecular Function: identical protein binding; protein binding; phosphoinositide binding; insulin receptor binding; epidermal growth factor receptor binding

Biological Process: intracellular protein transport; receptor internalization; vesicle organization and biogenesis; positive regulation of protein catabolic process; retrograde transport, endosome to Golgi