Human CTNNBIP1 Recombinant Protein – Cat# MBS1441764

Beta-Catenin-Interacting Protein 1 (CTNNBIP1) Human Recombinant Protein

Name: CTNNBIP1 Recombinant Protein; Human; MyBioSource
Brand: MyBioSource
SKU: MBS1441764
Price: 385 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1441764

Prevents the interaction between CTNNB1 and TCF family members, and acts as negative regulator of the Wnt signaling pathway. More details

$385 / 0.02 mg (E-Coli) +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Beta-catenin-interacting protein 1 (CTNNBIP1), Recombinant Protein

Full Product Name

Recombinant Human Beta-catenin-interacting protein 1 (CTNNBIP1)

Product Gene Name

CTNNBIP1 recombinant protein

Product Synonym Gene Name

CTNNBIP1; ICAT

Product Synonym Names

Beta-catenin-interacting protein 1; Inhibitor of beta-catenin and Tcf-4

Sequence

MNREGAPGKS PEEMYIQQKV RVLLMLRKMG SNLTASEEEF LRTYAGVVNS QLSQLPPHSI DQGAEDVVMA FSRSETEDRR Q

Host

E Coli or Yeast or Baculovirus or Mammalian Cell

Form/Format

Lyophilized or liquid (Format to be determined during the manufacturing process)

Purity/Purification

Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)

Preparation and Storage

Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Molecular Weight

36.2 kDa

Sequence Positions

1-81aa; Full Length

Tag Information

This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.

Sterility

Sterile filter available upon request.

Endotoxin

Low endotoxin available upon request.

OMIM

607758

3D Structure

ModBase 3D Structure for Q9NSA3

Species

Homo sapiens (Human)

Product Categories/Family for CTNNBIP1 recombinant protein

Signal Transduction

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of CTNNBIP1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CTNNBIP1 purchase

MBS1441764 is a recombinant protein targeting CTNNBIP1. Also known as Recombinant Human Beta-catenin-interacting protein 1 (CTNNBIP1). Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for CTNNBIP1. It may not necessarily be applicable to this product.

NCBI GI #

59889555

NCBI GeneID

56998

NCBI Accession #

NP_001012329.1

UniProt Primary Accession #

Q9NSA3

UniProt Secondary Accession #

Q5T4V2

UniProt Related Accession #

Q9NSA3

GenBank Nucleotide #

NM_001012329.1

NCBI Official Full Name

beta-catenin-interacting protein 1

NCBI Official Synonym Full Names

catenin, beta interacting protein 1

NCBI Official Symbol

CTNNBIP1

NCBI Official Synonym Symbols

ICAT

UniProt Protein Name

Beta-catenin-interacting protein 1

UniProt Synonym Protein Names

Inhibitor of beta-catenin and Tcf-4

Protein Family

Beta-catenin-interacting protein

UniProt Gene Name

CTNNBIP1

UniProt Synonym Gene Names

ICAT

UniProt Entry Name

CNBP1_HUMAN

NCBI Protein Information

beta-catenin-interacting protein 1; inhibitor of beta-catenin and Tcf-4; beta-catenin-interacting protein ICAT

NCBI Summary for CTNNBIP1

The protein encoded by this gene binds CTNNB1 and prevents interaction between CTNNB1 and TCF family members. The encoded protein is a negative regulator of the Wnt signaling pathway. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

UniProt Comments for CTNNBIP1

CTNNBIP1: Prevents the interaction between CTNNB1 and TCF family members, and acts as negative regulator of the Wnt signaling pathway. Belongs to the CTNNBIP1 family.

Protein type: Inhibitor; Cell development/differentiation

Chromosomal Location of Human Ortholog: 1p36.22

Cellular Component: nucleoplasm; cytoplasm; cytosol; beta-catenin destruction complex; nucleus

Molecular Function: protein binding; beta-catenin binding

Biological Process: anterior/posterior pattern formation; positive regulation of monocyte differentiation; positive regulation of osteoblast differentiation; Wnt receptor signaling pathway; negative regulation of Wnt receptor signaling pathway; negative regulation of smooth muscle cell proliferation; ureteric bud branching; negative regulation of transcription factor activity; negative regulation of protein binding; regulation of vascular permeability during acute inflammatory response; negative regulation of DNA binding

Research Articles on CTNNBIP1

1. PTHrP was found to inhibit DKK1 expression through c-Jun-mediated inhibition of beta-catenin activity on the DKK1 promoter.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with CTNNBIP1 recombinant protein

Reference Product	PubMed Publications
CTNNB1 recombinant protein	>18 publications with CTNNBIP1 and CTNNB1
TCF7L2 recombinant protein	>1 publications with CTNNBIP1 and TCF7L2

Pathways associated with CTNNBIP1 recombinant protein

Products by Pathway	Pathway Diagram
Regulation Of Wnt-mediated Beta Catenin Signaling And Target Gene Transcription Pathway antibodies	Regulation Of Wnt-mediated Beta Catenin Signaling And Target Gene Transcription Pathway Diagram
Wnt Signaling Pathway NetPath antibodies	Wnt Signaling Pathway NetPath Diagram
Wnt Signaling Pathway antibodies	Wnt Signaling Pathway Diagram
Wnt Signaling Pathway antibodies	Wnt Signaling Pathway Diagram

Diseases associated with CTNNBIP1 recombinant protein

Disease Name	Pubmed Publications
Liver Diseases Antibodies	>2 publications with CTNNBIP1 and Liver Diseases
Carcinoma, Hepatocellular Antibodies	>1 publications with CTNNBIP1 and Carcinoma, Hepatocellular
Congenital Abnormalities Antibodies	>1 publications with CTNNBIP1 and Congenital Abnormalities
Abnormalities, Multiple Antibodies	>1 publications with CTNNBIP1 and Abnormalities, Multiple
Hepatomegaly Antibodies	>1 publications with CTNNBIP1 and Hepatomegaly
Fibrosis Antibodies	>1 publications with CTNNBIP1 and Fibrosis
Necrosis Antibodies	>1 publications with CTNNBIP1 and Necrosis
Hyperplasia Antibodies	>1 publications with CTNNBIP1 and Hyperplasia

Organs/Tissues associated with CTNNBIP1 recombinant protein

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>5 publications with CTNNBIP1 and Blood
Kidney Antibodies	>4 publications with CTNNBIP1 and Kidney
Liver Antibodies	>3 publications with CTNNBIP1 and Liver
Eye Antibodies	>3 publications with CTNNBIP1 and Eye
Connective Tissue Antibodies	>2 publications with CTNNBIP1 and Connective Tissue
Bone Antibodies	>1 publications with CTNNBIP1 and Bone
Uncharacterized Tissue Antibodies	>1 publications with CTNNBIP1 and Uncharacterized Tissue
Prostate Antibodies	>1 publications with CTNNBIP1 and Prostate
Vascular Antibodies	>1 publications with CTNNBIP1 and Vascular
Skin Antibodies	>1 publications with CTNNBIP1 and Skin