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Signal Transducing Adapter Molecule 1 (STAM) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1441781

This gene was identified by the rapid tyrosine-phosphorylation of its product in response to cytokine stimulation. The encoded protein contains a SH3 domain and the immunoreceptor tyrosine-based activation motif (ITAM). This protein associates with JAK3 and… More details

$1345 / 0.02 mg (E-Coli) +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Signal transducing adapter molecule 1 (STAM), Recombinant Protein
Full Product Name
Recombinant Human Signal transducing adapter molecule 1 (STAM)
Product Gene Name
Product Synonym Gene Name
STAM
Sequence
PLFATNPFDQ DVEKATSEMN TAEDWGLILD ICDKVGQSRT GPKDCLRSIM RRVNHKDPHV AMQALTLLGA CVSNCGKIFH LEVCSRDFAS EVSNVLNKGH PKVCEKLKAL MVEWTDEFKN DPQLSLISAM IKNLKEQGVT FPAIGSQAAE QAKASPALVA KDPGTVANKK EEEDLAKAIE LSLKEQRQQS TTLSTLYPST SSLLTNHQHE GRKVRAIYDF EAAEDNELTF KAGEIITVLD DSDPNWWKGE THQGIGLFPS NFVTADLTAE PEMIKTEKKT VQFSDDVQVE TIEPEPEPAF IDEDKMDQLL QMLQSTDPSD DQPDLPELLH LEAMCHQMGP LIDEKLEDID RKHSELSELN VKVMEALSLY TKLMNEDPMY SMYAKLQNQP YYMQSSGVSG SQVYAGPPPS GAYLVAGNAQ MSHLQSYSLP PEQLSSLSQA VVPPSANPAL PSQQTQAAYP NTMVSSVQGN TYPSQAPVYS PPPAATAAAA TADVTLYQNA GPNMPQVPNY NLTSSTLPQP GGSQQPPQPQ QPYSQKALL
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
44,972 Da
Sequence Positions
2-540, Full length protein
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
OMIM
601899
3D Structure
ModBase 3D Structure for Q92783
Species
Human
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of STAM recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for STAM purchase

MBS1441781 is a recombinant protein targeting STAM. Also known as Recombinant Human Signal transducing adapter molecule 1 (STAM). Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for STAM. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
signal transducing adapter molecule 1 isoform a
NCBI Official Synonym Full Names
signal transducing adaptor molecule
NCBI Official Symbol
STAM
NCBI Official Synonym Symbols
STAM1; STAM-1
UniProt Protein Name
Signal transducing adapter molecule 1
UniProt Gene Name
STAM
UniProt Synonym Gene Names
STAM1; STAM-1
NCBI Protein Information
signal transducing adapter molecule 1

NCBI Summary for STAM

This gene encodes a member of the signal-transducing adaptor molecule family. These proteins mediate downstream signaling of cytokine receptors and also play a role in ER to Golgi trafficking by interacting with the coat protein II complex. The encoded protein also associates with hepatocyte growth factor-regulated substrate to form the endosomal sorting complex required for transport-0 (ESCRT-0), which sorts ubiquitinated membrane proteins to the ESCRT-1 complex for lysosomal degradation. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Feb 2011]
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UniProt Comments for STAM

Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes.
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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