Human CDKN3 Recombinant Protein – Cat# MBS144188

Cyclin-Dependent Kinase Inhibitor 3 (CDKN3) Human Recombinant Protein

Name: CDKN3 Recombinant Protein; Human; MyBioSource
Brand: MyBioSource
SKU: MBS144188
Price: 250 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS144188

Description: CDKN3 Human Recombinant fused with a 20 amino acid His tag at N-terminus produced in E Coli is a single, non-glycosylated, polypeptide chain containing 232 amino acids (1-212 a.a.) and having a molecular mass of 25.9kDa. The CDKN3 is purified by… More details

$250 / 0.005 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Cyclin-Dependent Kinase Inhibitor 3 (CDKN3), Recombinant Protein

Full Product Name

Recombinant Human Cyclin-Dependent Kinase Inhibitor 3

Product Gene Name

CDKN3 recombinant protein

Product Synonym Names

CDKN3 Human; Cyclin-Dependent Kinase Inhibitor 3 Human Recombinant; Cyclin-dependent kinase inhibitor 3; CDK2-associated dual-specificity phosphatase; Cyclin-dependent kinase interactor 1; Cyclin-dependent kinase-interacting protein 2; Kinase-associated phosphatase; KAP; CDI1; CIP2; KAP1; FLJ25787; MGC70625; CDKN3

Sequence

MGSSHHH HHH SSGLVPRGSH MKPPSSIQTS EFDSSDEEPI EDEQTPIHIS WLSLSRVNCS QFLGLCALPG CKFKDVRRNV QKDTEELKSC GIQDIFVFCT RGELSKYRVP NLLDLYQQCG IITHHHPIAD GGTPDIASCC EIMEELTTCL KNYRKTLIHC YGGLGRSCLV AACLLLYLSD TISPEQAIDS LRDLRGSGAI QTIKQYNYLH EFRDKLAAHL SSRDSQSRSV SR

Host

E Coli

Form/Format

The CDKN3 solution (0.5 mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 1mM DTT, 40% glycerol and 0.1M NaCl.
Sterile Filtered colorless solution.

Purity/Purification

Greater than 90.0% as determined by SDS-PAGE.

Preparation and Storage

CDKN3 should be stored desiccated below -18 degree C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.

Molecular Weight

19,359 Da

OMIM

114550

3D Structure

ModBase 3D Structure for Q16667

Product Categories/Family for CDKN3 recombinant protein

Protein Kinases; Enzymes; Cyclin-Dependent Kinase

Other Notes

Small volumes of CDKN3 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CDKN3 purchase

MBS144188 is a recombinant protein targeting CDKN3. Also known as Recombinant Human Cyclin-Dependent Kinase Inhibitor 3. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for CDKN3. It may not necessarily be applicable to this product.

NCBI GI #

195927025

NCBI GeneID

1033

NCBI Accession #

NP_001124323.1

UniProt Primary Accession #

Q16667

UniProt Secondary Accession #

Q53ZU6; Q5U0M4; Q6P1N8; Q99585; Q9BPW7; Q9BY36; Q9C042; Q9C046; Q9C047; Q9C049; Q9C051

UniProt Related Accession #

Q16667

GenBank Nucleotide #

NM_001130851.1

NCBI Official Full Name

cyclin-dependent kinase inhibitor 3 isoform 2

NCBI Official Synonym Full Names

cyclin-dependent kinase inhibitor 3

NCBI Official Symbol

CDKN3

NCBI Official Synonym Symbols

KAP; CDI1; CIP2; KAP1

UniProt Protein Name

Cyclin-dependent kinase inhibitor 3

UniProt Synonym Protein Names

CDK2-associated dual-specificity phosphatase; Cyclin-dependent kinase interactor 1; Cyclin-dependent kinase-interacting protein 2; Kinase-associated phosphatase

Protein Family

Cyclin-dependent kinase inhibitor

UniProt Gene Name

CDKN3

UniProt Synonym Gene Names

CDI1; CIP2; KAP

UniProt Entry Name

CDKN3_HUMAN

NCBI Protein Information

cyclin-dependent kinase inhibitor 3; CDK2-associated dual specificity phosphatase; CDK2-associated dual-specificity phosphatase; Cdk-associated protein phosphatase; cyclin-dependent kinase interacting protein 2; cyclin-dependent kinase interactor 1; cyclin-dependent kinase-interacting protein 2; kinase associated phosphatase; kinase-associated phosphatase

NCBI Summary for CDKN3

The protein encoded by this gene belongs to the dual specificity protein phosphatase family. It was identified as a cyclin-dependent kinase inhibitor, and has been shown to interact with, and dephosphorylate CDK2 kinase, thus prevent the activation of CDK2 kinase. This gene was reported to be deleted, mutated, or overexpressed in several kinds of cancers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]

UniProt Comments for CDKN3

CDKN3: May play a role in cell cycle regulation. Dual specificity phosphatase active toward substrates containing either phosphotyrosine or phosphoserine residues. Dephosphorylates CDK2 at 'Thr-160' in a cyclin-dependent manner. Defects in CDKN3 are found in patients with hepatocellular carcinoma (HCC). Belongs to the protein-tyrosine phosphatase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; EC 3.1.3.16; Protein phosphatase, dual-specificity; Cell cycle regulation; EC 3.1.3.48

Chromosomal Location of Human Ortholog: 14q22

Cellular Component: perinuclear region of cytoplasm; cytoplasm

Molecular Function: protein binding; protein tyrosine/serine/threonine phosphatase activity; protein tyrosine phosphatase activity; protein serine/threonine phosphatase activity

Biological Process: negative regulation of cell proliferation; regulation of cyclin-dependent protein kinase activity; cell cycle arrest; G1/S transition of mitotic cell cycle

Disease: Hepatocellular Carcinoma

Research Articles on CDKN3

1. CDKN3 may play an important role in the development and proliferation of epithelial ovarian cancer

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with CDKN3 recombinant protein

Disease Name	Pubmed Publications
Adenocarcinoma Antibodies	>9 publications with CDKN3 and Adenocarcinoma
Liver Diseases Antibodies	>8 publications with CDKN3 and Liver Diseases
Liver Neoplasms Antibodies	>7 publications with CDKN3 and Liver Neoplasms
Breast Neoplasms Antibodies	>6 publications with CDKN3 and Breast Neoplasms
Carcinoma, Hepatocellular Antibodies	>6 publications with CDKN3 and Carcinoma, Hepatocellular
Neoplasms, Experimental Antibodies	>5 publications with CDKN3 and Neoplasms, Experimental
Lung Neoplasms Antibodies	>3 publications with CDKN3 and Lung Neoplasms
Cell Transformation, Neoplastic Antibodies	>3 publications with CDKN3 and Cell Transformation, Neoplastic
Fibrosis Antibodies	>2 publications with CDKN3 and Fibrosis
Hepatomegaly Antibodies	>1 publications with CDKN3 and Hepatomegaly

Organs/Tissues associated with CDKN3 recombinant protein

Organ/Tissue Name	Pubmed Publications
Liver Antibodies	>10 publications with CDKN3 and Liver
Prostate Antibodies	>5 publications with CDKN3 and Prostate
Brain Antibodies	>4 publications with CDKN3 and Brain
Lung Antibodies	>3 publications with CDKN3 and Lung
Uterus Antibodies	>2 publications with CDKN3 and Uterus
Mouth Antibodies	>1 publications with CDKN3 and Mouth
Embryonic Tissue Antibodies	>1 publications with CDKN3 and Embryonic Tissue
Blood Antibodies	>1 publications with CDKN3 and Blood
Stomach Antibodies	>1 publications with CDKN3 and Stomach
Kidney Antibodies	>1 publications with CDKN3 and Kidney