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DNA-Directed RNA Polymerase II Subunit RPB4 (POLR2D) Mouse Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1442356

This gene encodes the fourth largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. In yeast, this polymerase subunit is associated with the polymerase under suboptimal growth conditions and may have a… More details

$790 / 0.02 mg (E-Coli) +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
DNA-directed RNA polymerase II subunit RPB4 (Polr2d), Recombinant Protein
Full Product Name
Recombinant Mouse DNA-directed RNA polymerase II subunit RPB4 (Polr2d)
Product Gene Name
Polr2d recombinant protein
Product Synonym Gene Name
Polr2d
Sequence
MAAGGSDPRA GDVEEDASQL IFPKEFETAE TLLNSEVHML LEHRKQQNES AEDEQELSEV FMKTLNYTAR FSRFKNRETI ASVRSLLLQK KLHKFELACL ANLCPETAEE SKALIPSLEG RFEDEELQQI LDDIQTKRSF QY
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
16,311 Da
Sequence Positions
1-142, full length protein
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
3D Structure
ModBase 3D Structure for Q9D7M8
Species
Mouse
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of Polr2d recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Polr2d purchase

MBS1442356 is a recombinant protein targeting Polr2d. Also known as Recombinant Mouse DNA-directed RNA polymerase II subunit RPB4 (Polr2d). Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for Polr2d. It may not necessarily be applicable to this product.

NCBI GI #
21312246
NCBI GeneID
69241
NCBI Accession #
NP_081278.1
UniProt Primary Accession #
Q9D7M8
UniProt Secondary Accession #
Q6ZWW0; Q78KE6
UniProt Related Accession #
Q9D7M8
GenBank Nucleotide #
NM_027002.4
NCBI Official Full Name
DNA-directed RNA polymerase II subunit RPB4 isoform 1
NCBI Official Synonym Full Names
polymerase (RNA) II (DNA directed) polypeptide D
NCBI Official Symbol
Polr2d
NCBI Official Synonym Symbols
RBP4; HSRBP4; 2310002G05Rik; 2610028L19Rik
UniProt Protein Name
DNA-directed RNA polymerase II subunit RPB4
UniProt Synonym Protein Names
DNA-directed RNA polymerase II subunit D
UniProt Gene Name
Polr2d
UniProt Synonym Gene Names
RNA polymerase II subunit B4
NCBI Protein Information
DNA-directed RNA polymerase II subunit RPB4

UniProt Comments for Polr2d

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB4 is part of a subcomplex with RPB7 that binds to a pocket formed by RPB1, RPB2 and RPB6 at the base of the clamp element. The RBP4-RPB7 subcomplex seems to lock the clamp via RPB7 in the closed conformation thus preventing double-stranded DNA to enter the active site cleft. The RPB4-RPB7 subcomplex binds single-stranded DNA and RNA ().
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with Polr2d recombinant protein

 Products by Pathway  Pathway Diagram
 DNA Repair Pathway antibodies  DNA Repair Pathway Diagram
 Dual Incision Reaction In TC-NER Pathway antibodies  Dual Incision Reaction In TC-NER Pathway Diagram
 Epstein-Barr Virus Infection Pathway antibodies  Epstein-Barr Virus Infection Pathway Diagram
 Epstein-Barr Virus Infection Pathway antibodies  Epstein-Barr Virus Infection Pathway Diagram
 Formation Of RNA Pol II Elongation Complex Pathway antibodies  Formation Of RNA Pol II Elongation Complex Pathway Diagram
 Formation Of The Early Elongation Complex Pathway antibodies  Formation Of The Early Elongation Complex Pathway Diagram
 Formation Of Transcription-coupled NER (TC-NER) Repair Complex Pathway antibodies  Formation Of Transcription-coupled NER (TC-NER) Repair Complex Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Huntington's Disease Pathway antibodies  Huntington's Disease Pathway Diagram
 Huntington's Disease Pathway antibodies  Huntington's Disease Pathway Diagram

Diseases associated with Polr2d recombinant protein

 Disease Name  Pubmed Publications
 Disease Models, Animal Antibodies  >1 publications with Polr2d and Disease Models, Animal
 Neoplasms Antibodies  >1 publications with Polr2d and Neoplasms
 Weight Loss Antibodies  >1 publications with Polr2d and Weight Loss

Organs/Tissues associated with Polr2d recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >1 publications with Polr2d and Muscle
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