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Selenocysteinyl-Trna (SEPSECS) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS144290

Description: SEPSECS produced in E Coli is a single, non-glycosylated polypeptide chain containing 521 amino acids (1-501a.a.) and having a molecular mass of 57.9kDa.SEPSECS is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary… More details

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Testing Data View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
Selenocysteinyl-tRNA (SEPSECS), Recombinant Protein
Full Product Name
Recombinant Human Selenocysteinyl-tRNA(Sec) synthase
Product Gene Name
SEPSECS recombinant protein
Product Synonym Names
SEPSECS Human; Selenocysteinyl-tRNA(Sec) synthase Human Recombinant; SLA; SLA/LP autoantigen; SLA-p35; Selenocysteinyl-tRNA(Sec) synthase; Selenocysteine synthase; Liver-pancreas antigen; Soluble liver antigen; Sec synthase; UGA suppressor tRNA-associated protein
Sequence
MGSSHHH HHH SSGLVPRGSH MNRESFAAGE RLVSPAYVRQ GCEARRSHEH LIRLLLEKGK CPENGWDEST LELFLHELAI MDSNNFLGNC GVGEREGRVA SALVARRHYR FIHGIGRSGD ISAVQPKAAG SSLLNKITNS LVLDIIKLAG VHTVANCFVV PMATGMSLTL CFLTLRHKRP KAKYIIWPRI DQKSCFKSMI TAGFEPVVIE NVLEGDELRT DLKAVEAKVQ ELGPDCILCI HSTTSCFAPR VPDRLEELAV ICANYDIPHI VNNAYGVQSS KCMHLIQQGA RVGRIDAFVQ SLDKNFMVPV GGAIIAGFND SFIQEISKMY PGRASASPSL DVLITLLSLG SNGYKKLLKE RKEMFSYLSN QIKKLSEAYN ERLLHTPHNP ISLAMTLKTL DEHRDKAVTQ LGSMLFTRQV SGARVVPLGS MQTVSGYTFR GFMSHTNNYP CAYLNAASAI GMKMQDVDLF IKRLDRCLKA VRKERSKESD DNYDKTEDVD IEEMALKLDN VLLDTYQDAS S
Host
E Coli
Form/Format
The SEPSECS protein solution (0.5mg/1ml) is formulated in 20mM Tris-HCl buffer (pH8.0) 1mM DTT, 100mM NaCl and 10% glycerol.
Sterile Filtered clear solution.
Purity/Purification
Greater than 90% as determined by SDS-PAGE.
Preparation and Storage
Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Molecular Weight
55,411 Da
OMIM
613009
3D Structure
ModBase 3D Structure for Q9HD40

Product Categories/Family for SEPSECS recombinant protein

Enzymes; Synthase

Other Notes

Small volumes of SEPSECS recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SEPSECS purchase

MBS144290 is a recombinant protein targeting SEPSECS. Also known as Recombinant Human Selenocysteinyl-tRNA(Sec) synthase. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for SEPSECS. It may not necessarily be applicable to this product.

NCBI GI #
267844904
NCBI GeneID
51091
NCBI Accession #
NP_058651.3
UniProt Primary Accession #
Q9HD40
UniProt Secondary Accession #
Q0D2P3; Q17RT1; Q9NXZ5; Q9UGM9; Q9Y353; A8K8W1
UniProt Related Accession #
Q9HD40
GenBank Nucleotide #
NM_016955.3
NCBI Official Full Name
O-phosphoseryl-tRNA(Sec) selenium transferase
NCBI Official Synonym Full Names
Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase
NCBI Official Symbol
SEPSECS
NCBI Official Synonym Symbols
LP; SLA; PCH2D; SLA/LP
UniProt Protein Name
O-phosphoseryl-tRNA(Sec) selenium transferase
UniProt Synonym Protein Names
Liver-pancreas antigen; LP; SLA-p35; SLA/LP autoantigen; Selenocysteine synthase; Sec synthase; Selenocysteinyl-tRNA(Sec) synthase; Sep-tRNA:Sec-tRNA synthase; SepSecS; Soluble liver antigen; SLA; UGA suppressor tRNA-associated protein; tRNA(Ser/Sec)-associated antigenic protein
Protein Family
O-phosphoseryl-tRNA(Sec) selenium transferase
UniProt Gene Name
SEPSECS
UniProt Synonym Gene Names
TRNP48; LP; Sec synthase; SepSecS; SLA
UniProt Entry Name
SPCS_HUMAN
NCBI Protein Information
O-phosphoseryl-tRNA(Sec) selenium transferase; O-phosphoseryl-tRNA(Sec) selenium transferase; SLA-p35; SLA/LP autoantigen; UGA suppressor tRNA-associated protein; liver-pancreas antigen; soluble liver antigen; soluble liver antigen/liver pancreas antigen; tRNA(Ser/Sec)-associated antigenic protein

NCBI Summary for SEPSECS

The amino acid selenocysteine is the only amino acid that does not have its own tRNA synthetase. Instead, this amino acid is synthesized on its cognate tRNA in a three step process. The protein encoded by this gene catalyzes the third step in the process, the conversion of O-phosphoseryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec).[provided by RefSeq, Mar 2011]
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UniProt Comments for SEPSECS

SLA/LP: Converts O-phosphoseryl-tRNA(Sec) to selenocysteinyl- tRNA(Sec) required for selenoprotein biosynthesis. Defects in SEPSECS are the cause of pontocerebellar hypoplasia type 2D (PCH2D). PCH2D is a disorder characterized by postnatal onset of progressive atrophy of the cerebrum and cerebellum, microcephaly, profound mental retardation, spasticity, and variable seizures. Belongs to the SepSecS family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Transferase; RNA-binding; EC 2.9.1.2

Chromosomal Location of Human Ortholog: 4p15.2

Cellular Component: cytoplasm; nucleus

Molecular Function: protein binding; transferase activity, transferring selenium-containing groups; pyridoxal phosphate binding; tRNA binding

Biological Process: selenocysteine incorporation

Disease: Pontocerebellar Hypoplasia, Type 2d
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Research Articles on SEPSECS

1. structural analysis of the terminal catalytic complex in selenocysteine synthesis

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with SEPSECS recombinant protein

 Reference Product  PubMed Publications
 PSTK recombinant protein  >7 publications with SEPSECS and PSTK
 SELS recombinant protein  >1 publications with SEPSECS and SELS
 SEPHS1 recombinant protein  >1 publications with SEPSECS and SEPHS1

Pathways associated with SEPSECS recombinant protein

 Products by Pathway  Pathway Diagram
 Aminoacyl-tRNA Biosynthesis Pathway antibodies  Aminoacyl-tRNA Biosynthesis Pathway Diagram
 Aminoacyl-tRNA Biosynthesis Pathway antibodies  Aminoacyl-tRNA Biosynthesis Pathway Diagram
 Selenium Metabolism And Selenoproteins Pathway antibodies  Selenium Metabolism And Selenoproteins Pathway Diagram
 Selenocompound Metabolism Pathway antibodies  Selenocompound Metabolism Pathway Diagram
 Selenocompound Metabolism Pathway antibodies  Selenocompound Metabolism Pathway Diagram

Diseases associated with SEPSECS recombinant protein

 Disease Name  Pubmed Publications
 Congenital Abnormalities Antibodies  >1 publications with SEPSECS and Congenital Abnormalities
 Hepatitis Antibodies  >1 publications with SEPSECS and Hepatitis
 Liver Diseases Antibodies  >1 publications with SEPSECS and Liver Diseases

Organs/Tissues associated with SEPSECS recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >3 publications with SEPSECS and Brain
 Placenta Antibodies  >1 publications with SEPSECS and Placenta
 Liver Antibodies  >1 publications with SEPSECS and Liver
 Blood Antibodies  >1 publications with SEPSECS and Blood
 Muscle Antibodies  >1 publications with SEPSECS and Muscle
 Embryonic Tissue Antibodies  >1 publications with SEPSECS and Embryonic Tissue
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