Human PDXK Recombinant Protein – Cat# MBS144291

Pyridoxal Kinase (PDXK) Human Recombinant Protein

Name: PDXK Recombinant Protein; Pyridoxal Kinase; Human; MyBioSource
Brand: MyBioSource
SKU: MBS144291
Price: 250 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS144291

Description: PDXK Human Recombinant fused with a 24 amino acid His tag at N-terminus produced in E Coli is a single, non-glycosylated, polypeptide chain containing 336 amino acids (1-312 a.a.) and having a molecular mass of 37.6kDa. The PDXK is purified by… More details

$250 / 0.002 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Pyridoxal Kinase (PDXK), Recombinant Protein

Full Product Name

Recombinant Human Pyridoxal Kinase

Product Gene Name

PDXK recombinant protein

Product Synonym Names

PDXK Human; Pyridoxal Kinase Human Recombinant; Pyridoxal kinase; Pyridoxine kinase; PDXK; C21orf124; C21orf97; PKH; PNK; PRED79; FLJ31940; FLJ37311; MGC15873; MGC31754; MGC52346; DKFZp566A071

Sequence

MGSSHHH HHH SSGLVPRGSH MGSHME EECR VLSIQSHVIR GYVGNRAATF PLQVLGFEID AVNSVQFSNH TGYAHWKGQV LNSDELQELY EGLRLNNMNK YDYVLTGYTR DKSFLAMVVD IVQELKQQNP RLVYVCDPVL GDKWDGEGSM YVPEDLLPVY KEKVVPLADI ITPNQFEAEL LSGRKIHSQE EALRVMDMLH SMGPDTVVIT SSDLPSPQGS NYLIVLGSQR RRNPAGSVVM ERIRMDIRKV DAVFVGTGDL FAAMLLAWTH KHPNNLKVAC EKTVSTLHHV LQRTIQCAKA QAGEGVRPSP MQLELRMVQS KRDIEDPEIV VQATVL

Host

E Coli

Form/Format

The PDXK solution (1 mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 1mM DTT and 10% glycerol.
Sterile Filtered colorless solution.

Purity/Purification

Greater than 90.0% as determined by SDS-PAGE.

Preparation and Storage

PDXK should be stored desiccated below -18 degree C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.

Molecular Weight

26,827 Da

OMIM

179020

3D Structure

ModBase 3D Structure for O00764

Product Categories/Family for PDXK recombinant protein

Protein Kinases; Enzymes; Protein Kinases

Other Notes

Small volumes of PDXK recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PDXK purchase

MBS144291 is a recombinant protein targeting PDXK. Also known as Recombinant Human Pyridoxal Kinase. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for PDXK. It may not necessarily be applicable to this product.

NCBI GI #

4505701

NCBI GeneID

8566

NCBI Accession #

NP_003672.1

UniProt Primary Accession #

O00764

UniProt Secondary Accession #

Q7Z2Y0; Q9BS02

UniProt Related Accession #

O00764

GenBank Nucleotide #

NM_003681.4

NCBI Official Full Name

pyridoxal kinase

NCBI Official Synonym Full Names

pyridoxal (pyridoxine, vitamin B6) kinase

NCBI Official Symbol

PDXK

NCBI Official Synonym Symbols

PKH; PNK; PRED79; C21orf97; HEL-S-1a; C21orf124

UniProt Protein Name

Pyridoxal kinase

UniProt Synonym Protein Names

Pyridoxine kinase

Protein Family

Putative pyridoxine kinase

UniProt Gene Name

PDXK

UniProt Synonym Gene Names

C21orf124; C21orf97; PKH; PNK

UniProt Entry Name

PDXK_HUMAN

NCBI Protein Information

pyridoxal kinase; epididymis secretory sperm binding protein Li 1a; pyridoxamine kinase; pyridoxine kinase; vitamin B6 kinase

NCBI Summary for PDXK

The protein encoded by this gene phosphorylates vitamin B6, a step required for the conversion of vitamin B6 to pyridoxal-5-phosphate, an important cofactor in intermediary metabolism. The encoded protein is cytoplasmic and probably acts as a homodimer. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]

UniProt Comments for PDXK

PDXK: Required for synthesis of pyridoxal-5-phosphate from vitamin B6. Belongs to the pyridoxine kinase family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Cofactor and Vitamin Metabolism - vitamin B6; EC 2.7.1.35; Kinase, other

Chromosomal Location of Human Ortholog: 21q22.3

Cellular Component: nucleoplasm; cytoplasm; nucleus; cytosol

Molecular Function: potassium ion binding; sodium ion binding; protein homodimerization activity; zinc ion binding; pyridoxal kinase activity; magnesium ion binding; lithium ion binding; ATP binding; pyridoxal phosphate binding

Biological Process: cell proliferation; vitamin metabolic process; vitamin B6 metabolic process; pyridoxal 5'-phosphate salvage; phosphorylation; water-soluble vitamin metabolic process; pyridoxal phosphate biosynthetic process

Research Articles on PDXK

1. The affected pyridoxine metabolism is discussed as an inborn genetic trait in epilepsy in general, rather than a specific sign of pyridoxine-dependent epilepsy solely.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with PDXK recombinant protein

Reference Product	PubMed Publications
PDXP recombinant protein	>3 publications with PDXK and PDXP
TRAPPC4 recombinant protein	>1 publications with PDXK and TRAPPC4
DBP recombinant protein	>1 publications with PDXK and DBP
TEF recombinant protein	>1 publications with PDXK and TEF

Pathways associated with PDXK recombinant protein

Products by Pathway	Pathway Diagram
Defective AMN Causes Hereditary Megaloblastic Anemia 1 Pathway antibodies	Defective AMN Causes Hereditary Megaloblastic Anemia 1 Pathway Diagram
Defective BTD Causes Biotidinase Deficiency Pathway antibodies	Defective BTD Causes Biotidinase Deficiency Pathway Diagram
Defective CD320 Causes Methylmalonic Aciduria Pathway antibodies	Defective CD320 Causes Methylmalonic Aciduria Pathway Diagram
Defective CUBN Causes Hereditary Megaloblastic Anemia 1 Pathway antibodies	Defective CUBN Causes Hereditary Megaloblastic Anemia 1 Pathway Diagram
Defective GIF Causes Intrinsic Factor Deficiency Pathway antibodies	Defective GIF Causes Intrinsic Factor Deficiency Pathway Diagram
Defective HLCS Causes Multiple Carboxylase Deficiency Pathway antibodies	Defective HLCS Causes Multiple Carboxylase Deficiency Pathway Diagram
Defective LMBRD1 Causes Methylmalonic Aciduria And Homocystinuria Type CblF Pathway antibodies	Defective LMBRD1 Causes Methylmalonic Aciduria And Homocystinuria Type CblF Pathway Diagram
Defective MMAA Causes Methylmalonic Aciduria Type CblA Pathway antibodies	Defective MMAA Causes Methylmalonic Aciduria Type CblA Pathway Diagram
Defective MMAB Causes Methylmalonic Aciduria Type CblB Pathway antibodies	Defective MMAB Causes Methylmalonic Aciduria Type CblB Pathway Diagram
Defective MMACHC Causes Methylmalonic Aciduria And Homocystinuria Type CblC Pathway antibodies	Defective MMACHC Causes Methylmalonic Aciduria And Homocystinuria Type CblC Pathway Diagram

Diseases associated with PDXK recombinant protein

Disease Name	Pubmed Publications
Carcinoma Antibodies	>5 publications with PDXK and Carcinoma
Cardiovascular Diseases Antibodies	>1 publications with PDXK and Cardiovascular Diseases
Seizures Antibodies	>1 publications with PDXK and Seizures
Neoplasms, Experimental Antibodies	>1 publications with PDXK and Neoplasms, Experimental
Poisoning Antibodies	>1 publications with PDXK and Poisoning
Atrophy Antibodies	>1 publications with PDXK and Atrophy
Disease Models, Animal Antibodies	>1 publications with PDXK and Disease Models, Animal
Inflammation Antibodies	>1 publications with PDXK and Inflammation
Hyperplasia Antibodies	>1 publications with PDXK and Hyperplasia
Necrosis Antibodies	>1 publications with PDXK and Necrosis

Organs/Tissues associated with PDXK recombinant protein

Organ/Tissue Name	Pubmed Publications
Lung Antibodies	>4 publications with PDXK and Lung
Brain Antibodies	>3 publications with PDXK and Brain
Liver Antibodies	>2 publications with PDXK and Liver
Muscle Antibodies	>1 publications with PDXK and Muscle
Blood Antibodies	>1 publications with PDXK and Blood
Embryonic Tissue Antibodies	>1 publications with PDXK and Embryonic Tissue