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Serine/Threonine-Protein Phosphatase 2a 56 Kda Regulatory Subunit Beta Isoform (PPP2R5B) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1442921

MBS1442921 is a recombinant protein targeting PPP2R5B. Also known as Recombinant Human Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform (PPP2R5B). Host: E Coli or Yeast or Baculovirus or Mammalian Cell. More details

$1295 / 0.02 mg (E-Coli) +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform (PPP2R5B), Recombinant Protein
Full Product Name
Recombinant Human Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform (PPP2R5B)
Product Gene Name
PPP2R5B recombinant protein
Product Synonym Gene Name
PPP2R5B
Sequence
METKLPPAST PTSPSSPGLS PVPPPDKVDG FSRRSLRRAR PRRSHSSSQF RYQSNQQELT PLPLLKDVPA SELHELLSRK LAQCGVMFDF LDCVADLKGK EVKRAALNEL VECVGSTRGV LIEPVYPDII RMISVNIFRT LPPSENPEFD PEEDEPNLEP SWPHLQLVYE FFLRFLESPD FQPSVAKRYV DQKFVLMLLE LFDSEDPRER EYLKTILHRV YGKFLGLRAY IRKQCNHIFL RFIYEFEHFN GVAELLEILG SIINGFALPL KTEHKQFLVR VLIPLHSVKS LSVFHAQLAY CVVQFLEKDA TLTEHVIRGL LKYWPKTCTQ KEVMFLGEME EILDVIEPSQ FVKIQEPLFK QVARCVSSPH FQVAERALYF WNNEYILSLI EDNCHTVLPA VFGTLYQVSK EHWNQTIVSL IYNVLKTFME MNGKLFDELT ASYKLEKQQE QQKAQERQEL WQGLEELRLR RLQGTQGAKE APLQRLTPQV AASGGQS
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
57,294 Da
Sequence Positions
1-497, Full length protein
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
OMIM
601644
3D Structure
ModBase 3D Structure for Q15173
Species
Human
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of PPP2R5B recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for PPP2R5B. It may not necessarily be applicable to this product.

NCBI GI #
5453952
NCBI GeneID
5526
NCBI Accession #
NP_006235.1
UniProt Primary Accession #
Q15173
UniProt Secondary Accession #
Q13853
UniProt Related Accession #
Q15173
GenBank Nucleotide #
NM_006244.3
NCBI Official Full Name
serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform
NCBI Official Synonym Full Names
protein phosphatase 2 regulatory subunit B'beta
NCBI Official Symbol
PPP2R5B
NCBI Official Synonym Symbols
B56B; PR61B; B56beta
UniProt Protein Name
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform
UniProt Synonym Protein Names
PP2A B subunit isoform B'-beta; PP2A B subunit isoform B56-beta; PP2A B subunit isoform PR61-beta; PP2A B subunit isoform R5-beta
Protein Family
Serine/threonine-protein phosphatase
UniProt Gene Name
PPP2R5B
NCBI Protein Information
serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform

NCBI Summary for PPP2R5B

The product of this gene belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a beta isoform of the regulatory subunit B56 subfamily. [provided by RefSeq, Jul 2008]
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UniProt Comments for PPP2R5B

As the regulatory component of the serine/threonine-protein phosphatase 2A (PP2A) holoenzyme, modulates substrate specificity, subcellular localization, and responsiveness to phosphorylation. The phosphorylated form mediates the interaction between PP2A and AKT1, leading to AKT1 dephosphorylation.

Research Articles on PPP2R5B

1. knockdown of B56beta attenuates hemin-induced K562 erythroid differentiation.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with PPP2R5B recombinant protein

 Reference Product  PubMed Publications
 CHEK2 recombinant protein  >1 publications with PPP2R5B and CHEK2

Pathways associated with PPP2R5B recombinant protein

 Products by Pathway  Pathway Diagram
 Activation Of Chaperones By IRE1alpha Pathway antibodies  Activation Of Chaperones By IRE1alpha Pathway Diagram
 Adaptive Immunity Signaling Pathway antibodies  Adaptive Immunity Signaling Pathway Diagram
 Beta-catenin Phosphorylation Cascade Pathway antibodies  Beta-catenin Phosphorylation Cascade Pathway Diagram
 CTLA4 Inhibitory Signaling Pathway antibodies  CTLA4 Inhibitory Signaling Pathway Diagram
 Cell Cycle, Mitotic Pathway antibodies  Cell Cycle, Mitotic Pathway Diagram
 Costimulation By The CD28 Family Pathway antibodies  Costimulation By The CD28 Family Pathway Diagram
 DNA Replication Pathway antibodies  DNA Replication Pathway Diagram
 Degradation Of Beta-catenin By The Destruction Complex Pathway antibodies  Degradation Of Beta-catenin By The Destruction Complex Pathway Diagram
 Diabetes Pathways antibodies  Diabetes Pathways Diagram
 Formation Of Platelet Plug Pathway antibodies  Formation Of Platelet Plug Pathway Diagram

Diseases associated with PPP2R5B recombinant protein

 Disease Name  Pubmed Publications
 Breast Neoplasms Antibodies  >2 publications with PPP2R5B and Breast Neoplasms
 Lung Neoplasms Antibodies  >1 publications with PPP2R5B and Lung Neoplasms
 Carcinoma Antibodies  >1 publications with PPP2R5B and Carcinoma
 Necrosis Antibodies  >1 publications with PPP2R5B and Necrosis

Organs/Tissues associated with PPP2R5B recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Pancreas Antibodies  >1 publications with PPP2R5B and Pancreas
 Thymus Antibodies  >1 publications with PPP2R5B and Thymus
 Lung Antibodies  >1 publications with PPP2R5B and Lung
 Brain Antibodies  >1 publications with PPP2R5B and Brain
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