Syndecan (SDCBP) Human Recombinant Protein

The protein encoded by this gene was initially identified as a molecule linking syndecan-mediated signaling to the cytoskeleton. The syntenin protein contains tandemly repeated PDZ domains that bind the cytoplasmic, C-terminal domains of a variety of transmembrane proteins. This protein may also affect cytoskeletal-membrane organization, cell adhesion, protein trafficking, and the activation of transcription factors. The protein is primarily localized to membrane-associated adherens junctions and focal adhesions but is also found at the endoplasmic reticulum and nucleus. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

syntenin: Seems to function as an adapter protein. In adherens junctions may function to couple syndecans to cytoskeletal proteins or signaling components. Seems to couple transcription factor SOX4 to the IL-5 receptor (IL5RA). May also play a role in vesicular trafficking. Seems to be required for the targeting of TGFA to the cell surface in the early secretory pathway. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Adaptor/scaffold; Cell adhesion; Motility/polarity/chemotaxis; Cytokine; Membrane protein, integral; Vesicle

Chromosomal Location of Human Ortholog: 8q12

Cellular Component: extracellular space; endoplasmic reticulum membrane; focal adhesion; cytosol; cytoskeleton; adherens junction; membrane; cytoplasm; plasma membrane; interleukin-5 receptor complex; melanosome; nucleus; vesicle

Molecular Function: protein C-terminus binding; syndecan binding; identical protein binding; protein homodimerization activity; ephrin receptor binding; protein N-terminus binding; protein binding; interleukin-5 receptor binding; frizzled binding; protein heterodimerization activity; neurexin binding; growth factor binding; cell adhesion molecule binding; cytoskeletal adaptor activity; glycoprotein binding

Biological Process: axon guidance; synaptic transmission; Ras protein signal transduction; ephrin receptor signaling pathway; positive regulation of JNK cascade; actin cytoskeleton organization and biogenesis; protein targeting to membrane; substrate-bound cell migration, cell extension; positive regulation of phosphorylation