RCD1 Required for Cell Differentiation1 (RQCD1) Human Recombinant Protein

This gene encodes a member of the highly conserved RCD1 protein family. The encoded protein is a transcriptional cofactor and a core protein of the CCR4-NOT complex. It may be involved in signal transduction as well as retinoic acid-regulated cell differentiation and development. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Oct 2012]

RQCD1: Transcription factor that down-regulates MYB- and JUN- dependent transcription. May play a role in cell differentiation. Can bind oligonucleotides, such as poly-G, poly-C or poly-T (in vitro), but the physiological relevance of this is not certain. Does not bind poly-A. Enhances ligand-dependent transcriptional activity of nuclear hormone receptors, including RARA, expect ESR1-mediated transcription that is not only slightly increased, if at all. Belongs to the RCD1 family.

Protein type: Cancer Testis Antigen (CTA)

Chromosomal Location of Human Ortholog: 2q35

Cellular Component: membrane; nucleus; cytosol; CCR4-NOT complex

Molecular Function: protein domain specific binding; protein binding; protein homodimerization activity

Biological Process: regulation of translation; poly(A) tail shortening; transcription, DNA-dependent; regulation of transcription, DNA-dependent; cytokine and chemokine mediated signaling pathway; gene expression; RNA-mediated gene silencing; sex differentiation; mRNA catabolic process, deadenylation-dependent decay; negative regulation of estrogen receptor signaling pathway