ASF1 Anti-Silencing Function 1 Homolog B (ASF1B) Human Recombinant Protein

This gene encodes a member of the H3/H4 family of histone chaperone proteins and is similar to the anti-silencing function-1 gene in yeast. The encoded protein is the substrate of the tousled-like kinase family of cell cycle-regulated kinases, and may play a key role in modulating the nucleosome structure of chromatin by ensuring a constant supply of histones at sites of nucleosome assembly. [provided by RefSeq, Jul 2008]

ASF1B: Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly. Cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly. Does not participate in replication-independent nucleosome deposition which is mediated by ASF1A and HIRA. Required for spermatogenesis. Interacts with histone H3 (including both histone H3.1 and H3.3) and histone H4. Interacts with the CHAF1A, CHAF1B and RBBP4 subunits of the CAF-1 complex. Interacts with HAT1, NASP, TAF1, TLK1 and TLK2. Highly expressed in testis and at lower levels in colon, small intestine and thymus. Belongs to the ASF1 family.

Chromosomal Location of Human Ortholog: 19p13.12

Cellular Component: nucleoplasm; protein complex; nuclear chromatin

Molecular Function: protein binding; histone binding

Biological Process: transcription, DNA-dependent; regulation of transcription, DNA-dependent; DNA replication-independent nucleosome assembly; multicellular organismal development; spermatogenesis; chromatin modification; cell differentiation; DNA replication-dependent nucleosome assembly