Human RGN Recombinant Protein – Cat# MBS144397

Regucalcin (RGN) Human Recombinant Protein

Name: RGN Recombinant Protein; Regucalcin; Human; MyBioSource
Brand: MyBioSource
SKU: MBS144397
Price: 250 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS144397

Description: RGN Human Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 319 amino acids (1-299 a.a.) and having a molecular mass of 35.4kDa.RGN is fused to a 20 amino acid His-tag at N-terminus & purified by… More details

$250 / 0.005 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Regucalcin (RGN), Recombinant Protein

Full Product Name

Recombinant Human Regucalcin

Product Gene Name

RGN recombinant protein

Product Synonym Names

RGN Human; Regucalcin Human Recombinant; Regucalcin; RC; Gluconolactonase; GNL; Senescence marker protein 30; SMP-30; RGN; SMP30

Sequence

MGSSHHH HHH SSGLVPRGSH MSSIKI ECVL PENCRCGESP VWEEVSNSLL FVDIPAKKVC RWDSFTKQVQ RVTMDAPVSS VALRQSGGYV ATIGTKFCAL NWKEQSAVVL ATVDNDKKNN RFNDGKVDPA GRYFAGTMAE ETAPAVLERH QGALYSLFPD HHVKKYFDQV DISNGLDWSL DHKIFYYIDS LSYSVDAFDY DLQTGQISNR RSVYKLEKEE QIPDGMCIDA EGKLWVACYN GGRVIRLDPV TGKRLQTVKL PVDKTTSCCF GGKNYSEMYV TCARDGMDPE GLLRQPEAGG IFKITGLGVK GIAPYSYAG.

Host

E Coli

Form/Format

RGN protein solution (0.5mg/ml) containing 20mM Tris-HCl, pH8.0, 2M Urea and 20% Glycerol.
Sterile filtered colorless solution.

Purity/Purification

Greater than 85.0% as determined by SDS-PAGE.

Molecular Weight

24,968 Da

OMIM

300212

3D Structure

ModBase 3D Structure for Q15493

Product Categories/Family for RGN recombinant protein

Recombinant & Natural Proteins; Recombinant Proteins

Other Notes

Small volumes of RGN recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for RGN purchase

MBS144397 is a recombinant protein targeting RGN. Also known as Recombinant Human Regucalcin. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for RGN. It may not necessarily be applicable to this product.

NCBI GI #

544583589

NCBI GeneID

9104

NCBI Accession #

NP_001269777.1

UniProt Primary Accession #

Q15493

UniProt Secondary Accession #

Q53FC9; Q5JRR5; A4FTW1; A8K271

UniProt Related Accession #

Q15493

GenBank Nucleotide #

NM_001282848.1

NCBI Official Full Name

regucalcin isoform 2

NCBI Official Synonym Full Names

regucalcin

NCBI Official Symbol

RGN

NCBI Official Synonym Symbols

RC; GNL; SMP30; HEL-S-41

UniProt Protein Name

Regucalcin

UniProt Synonym Protein Names

Gluconolactonase (EC:3.1.1.17); GNL; Senescence marker protein 30; SMP-30

Protein Family

Regucalcin

UniProt Gene Name

RGN

UniProt Synonym Gene Names

SMP30; RC; GNL; SMP-30

UniProt Entry Name

RGN_HUMAN

NCBI Protein Information

regucalcin; epididymis secretory protein Li 41; gluconolactonase; senescence marker protein 30

NCBI Summary for RGN

The protein encoded by this gene is a highly conserved, calcium-binding protein, that is preferentially expressed in the liver and kidney. It may have an important role in calcium homeostasis. Studies in rat indicate that this protein may also play a role in aging, as it shows age-associated down-regulation. This gene is part of a gene cluster on chromosome Xp11.3-Xp11.23. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

UniProt Comments for RGN

RGN: Gluconolactonase with low activity towards other sugar lactones, including gulonolactone and galactonolactone. Can also hydrolyze diisopropyl phosphorofluoridate and phenylacetate (in vitro). Calcium-binding protein. Modulates Ca(2+) signaling, and Ca(2+)-dependent cellular processes and enzyme activities. Belongs to the SMP-30/CGR1 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.1.1.17

Chromosomal Location of Human Ortholog: Xp11.3

Cellular Component: nucleoplasm; cytoplasm; nucleus

Molecular Function: zinc ion binding; gluconolactonase activity; calcium ion binding; enzyme regulator activity

Biological Process: L-ascorbic acid biosynthetic process; cellular calcium ion homeostasis; positive regulation of ATPase activity; regulation of calcium-mediated signaling

Research Articles on RGN

1. SMP30 can inhibit the proliferation and invasion of human hepatoma cells and thus can be regarded as a cancer suppressive factor.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with RGN recombinant protein

Reference Product	PubMed Publications
INS recombinant protein	>2 publications with RGN and INS

Pathways associated with RGN recombinant protein

Products by Pathway	Pathway Diagram
Ascorbate And Aldarate Metabolism Pathway antibodies	Ascorbate And Aldarate Metabolism Pathway Diagram
Ascorbate And Aldarate Metabolism Pathway antibodies	Ascorbate And Aldarate Metabolism Pathway Diagram
Carbon Metabolism Pathway antibodies	Carbon Metabolism Pathway Diagram
Carbon Metabolism Pathway antibodies	Carbon Metabolism Pathway Diagram
Degradation Of Aromatic Compounds Pathway antibodies	Degradation Of Aromatic Compounds Pathway Diagram
Degradation Of Aromatic Compounds Pathway antibodies	Degradation Of Aromatic Compounds Pathway Diagram
Metabolic Pathways antibodies	Metabolic Pathways Diagram
Pentose Phosphate Pathway antibodies	Pentose Phosphate Pathway Diagram
Pentose Phosphate Pathway antibodies	Pentose Phosphate Pathway Diagram

Diseases associated with RGN recombinant protein

Disease Name	Pubmed Publications
Liver Diseases Antibodies	>56 publications with RGN and Liver Diseases
Liver Neoplasms Antibodies	>34 publications with RGN and Liver Neoplasms
Disease Models, Animal Antibodies	>24 publications with RGN and Disease Models, Animal
Carcinoma, Hepatocellular Antibodies	>21 publications with RGN and Carcinoma, Hepatocellular
Necrosis Antibodies	>19 publications with RGN and Necrosis
Nervous System Diseases Antibodies	>14 publications with RGN and Nervous System Diseases
Fibrosis Antibodies	>13 publications with RGN and Fibrosis
Liver Neoplasms, Experimental Antibodies	>13 publications with RGN and Liver Neoplasms, Experimental
Drug-Induced Liver Injury Antibodies	>11 publications with RGN and Drug-Induced Liver Injury
Fatty Liver Antibodies	>10 publications with RGN and Fatty Liver

Organs/Tissues associated with RGN recombinant protein

Organ/Tissue Name	Pubmed Publications
Liver Antibodies	>186 publications with RGN and Liver
Kidney Antibodies	>70 publications with RGN and Kidney
Brain Antibodies	>36 publications with RGN and Brain
Muscle Antibodies	>24 publications with RGN and Muscle
Bone Antibodies	>14 publications with RGN and Bone
Lung Antibodies	>9 publications with RGN and Lung
Eye Antibodies	>8 publications with RGN and Eye
Testis Antibodies	>7 publications with RGN and Testis
Prostate Antibodies	>6 publications with RGN and Prostate
Connective Tissue Antibodies	>5 publications with RGN and Connective Tissue