Human BLK Recombinant Protein – Cat# MBS144443

B Lymphoid Tyrosine Kinase (BLK) Human Recombinant Protein

Name: BLK Recombinant Protein; B Lymphoid Tyrosine Kinase; Human; MyBioSource
Brand: MyBioSource
SKU: MBS144443
Price: 250 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS144443

Description: BLK Human Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 525 amino acids (1-505 a.a.) and having a molecular mass of 59.8kDa.BLK is fused to a 20 amino acid His-tag at N-terminus & purified by… More details

$250 / 0.002 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

B lymphoid tyrosine kinase (BLK), Recombinant Protein

Full Product Name

Recombinant Human B lymphoid tyrosine kinase

Product Gene Name

BLK recombinant protein

Product Synonym Names

BLK Human; B lymphoid tyrosine kinase Human Recombinant; Tyrosine-protein kinase Blk; B lymphocyte kinase; p55-Blk; BLK; MODY11; MGC10442

Sequence

MGSSHHH HHH SSGLVPRGSH MGLVSSKKPD KEKPIKEKDK GQWSPLKVSA QDKDAPPLPP LVVFNHLTPP PPDEHLDEDK HFVVALYDYT AMNDRDLQML KGEKLQVLKG TGDWWLARSL VTGREGYVPS NFVARVESLE MERWFFRSQG RKEAERQLLA PINKAGSFLI RESETNKGAF SLSVKDVTTQ GELIKHYKIR CLDEGGYYIS PRITFPSLQA LVQHYSKKGD GLCQRLTLPC VRPAPQNPWA QDEWEIPRQS LRLVRKLGSG QFGEVWMGYY KNNMKVAIKT LKEGTMSPEA FLGEANVMKA LQHERLVRLY AVVTKEPIYI VTEYMARGCL LDFLKTDEGS RLSLPRLIDM SAQIAEGMAY IERMNSIHRD LRAANILVSE ALCCKIADFG LARIIDSEYT AQEGAKFPIK WTAPEAIHFG VFTIKADVWS FGVLLMEVVT YGRVPYPGMS NPEVIRNLER GYRMPRPDTC PPELYRGVIA ECWRSRPEER PTFEFLQSVL EDFYTATERQ YELQP

Host

E Coli

Form/Format

BLK protein solution (0.25mg/ml) containing 20mM Tris-HCl buffer (pH8.0), 30% glycerol, 0.1M NaCl, 1mM DTT and 0.1mM PMSF.
Sterile Filtered colorless solution.

Purity/Purification

Greater than 80.0% as determined by SDS-PAGE.

Molecular Weight

57,706 Da

OMIM

191305

3D Structure

ModBase 3D Structure for P51451

Product Categories/Family for BLK recombinant protein

Protein Kinases; Enzymes; Protein Kinases

Other Notes

Small volumes of BLK recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for BLK purchase

MBS144443 is a recombinant protein targeting BLK. Also known as Recombinant Human B lymphoid tyrosine kinase. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for BLK. It may not necessarily be applicable to this product.

NCBI GI #

33469982

NCBI GeneID

640

NCBI Accession #

NP_001706.2

UniProt Primary Accession #

P51451

UniProt Secondary Accession #

Q16291; Q96IN1

UniProt Related Accession #

P51451

GenBank Nucleotide #

NM_001715.2

NCBI Official Full Name

tyrosine-protein kinase Blk

NCBI Official Synonym Full Names

BLK proto-oncogene, Src family tyrosine kinase

NCBI Official Symbol

BLK

NCBI Official Synonym Symbols

MODY11

UniProt Protein Name

Tyrosine-protein kinase Blk

UniProt Synonym Protein Names

B lymphocyte kinase; p55-Blk

Protein Family

Tyrosine-protein kinase

UniProt Gene Name

BLK

UniProt Entry Name

BLK_HUMAN

NCBI Protein Information

tyrosine-protein kinase Blk; B lymphoid tyrosine kinase; BLK nonreceptor tyrosine kinase; b lymphocyte kinase; p55-Blk

NCBI Summary for BLK

This gene encodes a nonreceptor tyrosine-kinase of the src family of proto-oncogenes that are typically involved in cell proliferation and differentiation. The protein has a role in B-cell receptor signaling and B-cell development. The protein also stimulates insulin synthesis and secretion in response to glucose and enhances the expression of several pancreatic beta-cell transcription factors. [provided by RefSeq, Aug 2010]

UniProt Comments for BLK

BLK: a nonreceptor tyrosine kinase of the Src family. Expressed predominantly in B lymphocytes

Protein type: Protein kinase, TK; EC 2.7.10.2; Kinase, protein; Protein kinase, tyrosine (non-receptor); TK group; Src family

Chromosomal Location of Human Ortholog: 8p23-p22

Cellular Component: extrinsic to internal side of plasma membrane

Molecular Function: protein binding; protein-tyrosine kinase activity; non-membrane spanning protein tyrosine kinase activity; ATP binding; receptor binding

Biological Process: B cell receptor signaling pathway; innate immune response; positive regulation of insulin secretion; transmembrane receptor protein tyrosine kinase signaling pathway; T cell differentiation; regulation of cell proliferation

Disease: Maturity-onset Diabetes Of The Young, Type 11

Research Articles on BLK

1. Report role of BLK genetic variants in confering risk of systemic lupus erythematosus in Chinese population.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with BLK recombinant protein

Reference Product	PubMed Publications
SYK recombinant protein	>26 publications with BLK and SYK
CSK recombinant protein	>7 publications with BLK and CSK
CD79A recombinant protein	>5 publications with BLK and CD79A
CD79B recombinant protein	>4 publications with BLK and CD79B
EGFR recombinant protein	>3 publications with BLK and EGFR
BLNK recombinant protein	>1 publications with BLK and BLNK
PLCG2 recombinant protein	>1 publications with BLK and PLCG2
CBL recombinant protein	>1 publications with BLK and CBL

Pathways associated with BLK recombinant protein

Products by Pathway	Pathway Diagram
Adaptive Immune System Pathway antibodies	Adaptive Immune System Pathway Diagram
Alpha-synuclein Signaling Pathway antibodies	Alpha-synuclein Signaling Pathway Diagram
Antigen Activates B Cell Receptor (BCR) Leading To Generation Of Second Messengers Pathway antibodies	Antigen Activates B Cell Receptor (BCR) Leading To Generation Of Second Messengers Pathway Diagram
Apoptosis Modulation And Signaling Pathway antibodies	Apoptosis Modulation And Signaling Pathway Diagram
B Cell Receptor Signaling Pathway antibodies	B Cell Receptor Signaling Pathway Diagram
CXCR4-mediated Signaling Events Pathway antibodies	CXCR4-mediated Signaling Events Pathway Diagram
Class I PI3K Signaling Events Pathway antibodies	Class I PI3K Signaling Events Pathway Diagram
EPHA Forward Signaling Pathway antibodies	EPHA Forward Signaling Pathway Diagram
Ephrin B Reverse Signaling Pathway antibodies	Ephrin B Reverse Signaling Pathway Diagram
Focal Adhesion Pathway antibodies	Focal Adhesion Pathway Diagram

Diseases associated with BLK recombinant protein

Disease Name	Pubmed Publications
Immune System Diseases Antibodies	>85 publications with BLK and Immune System Diseases
Lupus Erythematosus, Systemic Antibodies	>48 publications with BLK and Lupus Erythematosus, Systemic
Nervous System Diseases Antibodies	>23 publications with BLK and Nervous System Diseases
Arthritis, Rheumatoid Antibodies	>21 publications with BLK and Arthritis, Rheumatoid
Brain Diseases Antibodies	>17 publications with BLK and Brain Diseases
Inflammation Antibodies	>16 publications with BLK and Inflammation
Necrosis Antibodies	>14 publications with BLK and Necrosis
Breast Neoplasms Antibodies	>11 publications with BLK and Breast Neoplasms
Neoplasms, Experimental Antibodies	>10 publications with BLK and Neoplasms, Experimental
Lung Diseases Antibodies	>7 publications with BLK and Lung Diseases

Organs/Tissues associated with BLK recombinant protein

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>144 publications with BLK and Blood
Spleen Antibodies	>15 publications with BLK and Spleen
Lung Antibodies	>14 publications with BLK and Lung
Bone Marrow Antibodies	>13 publications with BLK and Bone Marrow
Lymph Node Antibodies	>9 publications with BLK and Lymph Node
Lymph Antibodies	>9 publications with BLK and Lymph
Thymus Antibodies	>5 publications with BLK and Thymus
Intestine Antibodies	>4 publications with BLK and Intestine
Connective Tissue Antibodies	>3 publications with BLK and Connective Tissue
Mammary Gland Antibodies	>3 publications with BLK and Mammary Gland