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T-Cell Immunoreceptor with Ig and ITIM Domains (TIGIT) Human Active Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1444441

Binds with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells. More details

$315 / 0.02 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
T-cell immunoreceptor with Ig and ITIM domains (TIGIT), Active Protein
Full Product Name
Recombinant Human T-cell immunoreceptor with Ig and ITIM domains
Product Gene Name
TIGIT active protein
Product Synonym Names
V-set and immunoglobulin domain-containing protein 9; V-set and transmembrane domain-containing protein 3
Sequence
MMTGTIETTG NISAEKGGSI ILQCHLSSTT AQVTQVNWEQ QDQLLAICNA DLGWHISPSF KDRVAPGPGL GLTLQSLTVN DTGEYFCIYH TYPDGTYTGR IFLEVLESSV AEHGARFQIP
Host
Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
Molecular Weight
29.1 kDa
Sequence Positions
22-141aa; Extracellular Domain
OMIM
612859
3D Structure
ModBase 3D Structure for Q495A1
Active Protein Note
Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.
Species
Homo sapiens (Human)
Production Note
Special Offer: The E Coli host-expressed protein is manufactured from a stock plasmid containing the protein gene. E Colihost-expressed protein is stocked in different unit sizes ranging from as small as 10 ug to as large as 1 mg. Bulk inventory is also available. The E Coli host-expressed protein has been ordered over and over again by researchers and has stood the test of time as both a robust protein and important target for the research community. It is part of our new program to make our most popular protein targets and corresponding hosts available in expanded unit sizes and with a quick processing time. Select E Coli host-expressed protein for the fastest delivery among all hosts. Please contact our technical support team or email to support@mybiosource.com for more details.

Product Categories/Family for TIGIT active protein

Immunology
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

SDS-Page of TIGIT active protein

Human TIGIT Active Protein – Cat# MBS1444441

Product References and Citations for TIGIT active protein

"The surface protein TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells." Yu X., Harden K., Gonzalez L.C., Francesco M., Chiang E., Irving B., Tom I., Ivelja S., Refino C.J., Clark H., Eaton D., Grogan J.L. Nat. Immunol. 10:48-57(2009)

Other Notes

Small volumes of TIGIT active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TIGIT purchase

MBS1444441 is an active protein targeting TIGIT. Also known as Recombinant Human T-cell immunoreceptor with Ig and ITIM domains. Host: Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for TIGIT. It may not necessarily be applicable to this product.

NCBI GI #
256600228
NCBI GeneID
201633
NCBI Accession #
NP_776160.2
UniProt Primary Accession #
Q495A1
UniProt Secondary Accession #
Q495A3; Q5JPD8; Q6MZS2; Q8N877
UniProt Related Accession #
Q495A1
GenBank Nucleotide #
NM_173799.3
NCBI Official Full Name
T-cell immunoreceptor with Ig and ITIM domains
NCBI Official Synonym Full Names
T-cell immunoreceptor with Ig and ITIM domains
NCBI Official Symbol
TIGIT
NCBI Official Synonym Symbols
VSIG9; VSTM3; WUCAM
UniProt Protein Name
T-cell immunoreceptor with Ig and ITIM domains
UniProt Synonym Protein Names
V-set and immunoglobulin domain-containing protein 9; V-set and transmembrane domain-containing protein 3
Protein Family
T-cell immunoreceptor with Ig and ITIM domains
UniProt Gene Name
TIGIT
UniProt Synonym Gene Names
VSIG9; VSTM3
UniProt Entry Name
TIGIT_HUMAN
NCBI Protein Information
T-cell immunoreceptor with Ig and ITIM domains

NCBI Summary for TIGIT

This gene encodes a member of the PVR (poliovirus receptor) family of immunoglobin proteins. The product of this gene is expressed on several classes of T cells including follicular B helper T cells (TFH). The protein has been shown to bind PVR with high affinity; this binding is thought to assist interactions between TFH and dendritic cells to regulate T cell dependent B cell responses.[provided by RefSeq, Sep 2009]
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UniProt Comments for TIGIT

TIGIT: Binds with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell surface; Membrane protein, integral

Chromosomal Location of Human Ortholog: 3q13.31

Cellular Component: cell surface; cell-cell adherens junction; integral to plasma membrane

Molecular Function: cell adhesion molecule binding; protein binding; protein homodimerization activity; receptor activity; receptor binding

Biological Process: cell recognition; heterophilic cell adhesion; homophilic cell adhesion; negative regulation of interleukin-12 production; negative regulation of T cell activation; positive regulation of interleukin-10 production
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Research Articles on TIGIT

1. a novel mechanism that links TIGIT expression with NK-cell functional heterogeneity, and this mechanism might partially explain why individuals have different susceptibilities to infection, autoimmune disease, and cancer.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with TIGIT active protein

 Reference Product  PubMed Publications
 CD226 active protein  >24 publications with TIGIT and CD226
 CD96 active protein  >10 publications with TIGIT and CD96
 PVR active protein  >9 publications with TIGIT and PVR
 PVRL1 active protein  >7 publications with TIGIT and PVRL1
 CRTAM active protein  >2 publications with TIGIT and CRTAM
 PVRL2 active protein  >1 publications with TIGIT and PVRL2
 PVRL3 active protein  >1 publications with TIGIT and PVRL3

Pathways associated with TIGIT active protein

 Products by Pathway  Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram

Diseases associated with TIGIT active protein

 Disease Name  Pubmed Publications
 Hypersensitivity Antibodies  >3 publications with TIGIT and Hypersensitivity
 Lung Diseases Antibodies  >2 publications with TIGIT and Lung Diseases
 Pneumonia Antibodies  >1 publications with TIGIT and Pneumonia
 Anemia, Aplastic Antibodies  >1 publications with TIGIT and Anemia, Aplastic
 Pregnancy Complications Antibodies  >1 publications with TIGIT and Pregnancy Complications

Organs/Tissues associated with TIGIT active protein

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >43 publications with TIGIT and Blood
 Spleen Antibodies  >3 publications with TIGIT and Spleen
 Lung Antibodies  >2 publications with TIGIT and Lung
 Lymph Node Antibodies  >2 publications with TIGIT and Lymph Node
 Kidney Antibodies  >1 publications with TIGIT and Kidney
 Thymus Antibodies  >1 publications with TIGIT and Thymus
 Mouth Antibodies  >1 publications with TIGIT and Mouth
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