Human TFAM Recombinant Protein – Cat# MBS144557

Transcription Factor-A (TFAM) Human Recombinant Protein

Name: TFAM Recombinant Protein; Transcription Factor-A; Human; MyBioSource
Brand: MyBioSource
SKU: MBS144557
Price: 250 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS144557

Description: TFAM produced in E Coli is a single, non-glycosylated polypeptide chain containing 225 amino acids (43-246.a.a) and having a molecular mass of 26.6kDa. TFAM is fused to a 21 amino acid His-tag at N-terminus & purified by proprietary… More details

$250 / 0.001 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Transcription Factor-A (TFAM), Recombinant Protein

Full Product Name

Recombinant Human Transcription Factor-A

Product Gene Name

TFAM recombinant protein

Product Synonym Names

TFAM Human; Transcription Factor-A Recombinant Human; Transcription factor A; mitochondrial; TCF6; TCF6L2; Mitochondrial transcription factor 1; Transcription factor 6-like 2; MtTF1; mtTFA; TCF6L1; TCF6L3

Sequence

MGSSHHH HHH SSGLVPRGS H MSSVLA SCPK KPVSSYLRFS KEQLPIFKAQ NPDAKTTELI RRIAQRWREL PDSKKKIYQD AYRAEWQVYK EEISRFKEQL TPSQIMSLEK EIMDKHLKRK AMTKKKELTL LGKPKRPRSA YNVYVAERFQ EAKGDSPQEK LKTVKENWKN LSDSEKELYI QHAKEDETRY HNEMKSWEEQ MIEVGRKDLL RRTIKKQRKY GAEEC

Host

E Coli

Form/Format

The TFAM protein solution (0.25mg/1ml) is formulated in 20 mM Tris-HCl buffer (pH8.0), 0.2M NaCl, 5mM DTT and 20% glycerol.

Purity/Purification

Greater than 85% as determined by SDS-PAGE.

Preparation and Storage

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozenat -20°C for longer periods of time. Please avoid freeze thaw cycles.

OMIM

600438

3D Structure

ModBase 3D Structure for Q00059

Physical Activity

Sterile Filtered clear solution.

Product Categories/Family for TFAM recombinant protein

Recombinant & Natural Proteins; Recombinant Proteins

Other Notes

Small volumes of TFAM recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TFAM purchase

MBS144557 is a recombinant protein targeting TFAM. Also known as Recombinant Human Transcription Factor-A. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for TFAM. It may not necessarily be applicable to this product.

NCBI GI #

399498566

NCBI GeneID

7019

NCBI Accession #

NP_001257711.1

UniProt Primary Accession #

Q00059

UniProt Secondary Accession #

Q5U0C6; A8MRB2; A9QXC6; B5BU05

UniProt Related Accession #

Q00059

GenBank Nucleotide #

NM_001270782.1

NCBI Official Full Name

transcription factor A, mitochondrial isoform 2

NCBI Official Synonym Full Names

transcription factor A, mitochondrial

NCBI Official Symbol

TFAM

NCBI Official Synonym Symbols

TCF6; MTTF1; MTTFA; TCF6L1; TCF6L2; TCF6L3

UniProt Protein Name

Transcription factor A, mitochondrial

UniProt Synonym Protein Names

Mitochondrial transcription factor 1; MtTF1; Transcription factor 6; TCF-6; Transcription factor 6-like 2

Protein Family

Transcription factor

UniProt Gene Name

TFAM

UniProt Synonym Gene Names

TCF6; TCF6L2; mtTFA; MtTF1; TCF-6

UniProt Entry Name

TFAM_HUMAN

NCBI Protein Information

transcription factor A, mitochondrial; mitochondrial transcription factor 1; mitochondrial transcription factor A; transcription factor 6; transcription factor 6-like 1; transcription factor 6-like 2 (mitochondrial transcription factor); transcription factor 6-like 3

NCBI Summary for TFAM

This gene encodes a key mitochondrial transcription factor containing two high mobility group motifs. The encoded protein also functions in mitochondrial DNA replication and repair. Sequence polymorphisms in this gene are associated with Alzheimer's and Parkinson's diseases. There are pseudogenes for this gene on chromosomes 6, 7, and 11. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

UniProt Comments for TFAM

TFAM: regulates mitochondrial transcription. Induced in humans by caloric restriction. Required for accurate and efficient promoter recognition by the mitochondrial RNA polymerase. Activates transcription by binding immediately upstream of transcriptional start sites. Is able to unwind and bend DNA. Involved in cisplatin resistance. Interacts with TFB1M and TFB2M.

Protein type: DNA-binding; Transcription regulation

Chromosomal Location of Human Ortholog: 10q21

Cellular Component: mitochondrion; mitochondrial matrix; cytosol; nucleus

Molecular Function: protein binding; heat shock protein binding; chromatin binding; DNA bending activity; transcription factor activity

Biological Process: chromatin remodeling; mitochondrial respiratory chain complex assembly; mitochondrion organization and biogenesis; regulation of transcription from RNA polymerase I promoter; organelle organization and biogenesis; positive regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; gene expression; DNA-dependent DNA replication; transcription from mitochondrial promoter; transcription initiation from mitochondrial promoter

Research Articles on TFAM

1. indicating that miRNA-214 and MTFA may become important candidates for developing promising therapeutic strategies for the treatment of cervical cancer

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with TFAM recombinant protein

Reference Product	PubMed Publications
NRF1 recombinant protein	>107 publications with TFAM and NRF1
TFB2M recombinant protein	>41 publications with TFAM and TFB2M
TFB1M recombinant protein	>26 publications with TFAM and TFB1M
POLRMT recombinant protein	>18 publications with TFAM and POLRMT
GABPA recombinant protein	>12 publications with TFAM and GABPA
GABPB1 recombinant protein	>1 publications with TFAM and GABPB1
TXN2 recombinant protein	>1 publications with TFAM and TXN2

Pathways associated with TFAM recombinant protein

Products by Pathway	Pathway Diagram
Energy Metabolism Pathway antibodies	Energy Metabolism Pathway Diagram
Gene Expression Pathway antibodies	Gene Expression Pathway Diagram
Huntington's Disease Pathway antibodies	Huntington's Disease Pathway Diagram
Huntington's Disease Pathway antibodies	Huntington's Disease Pathway Diagram
Mitochondrial Gene Expression Pathway antibodies	Mitochondrial Gene Expression Pathway Diagram
Mitochondrial Biogenesis Pathway antibodies	Mitochondrial Biogenesis Pathway Diagram
Mitochondrial Transcription Initiation Pathway antibodies	Mitochondrial Transcription Initiation Pathway Diagram
Organelle Biogenesis And Maintenance Pathway antibodies	Organelle Biogenesis And Maintenance Pathway Diagram
RNA Polymerase I, RNA Polymerase III, And Mitochondrial Transcription Pathway antibodies	RNA Polymerase I, RNA Polymerase III, And Mitochondrial Transcription Pathway Diagram
Transcription From Mitochondrial Promoters Pathway antibodies	Transcription From Mitochondrial Promoters Pathway Diagram

Diseases associated with TFAM recombinant protein

Disease Name	Pubmed Publications
Mitochondrial Diseases Antibodies	>105 publications with TFAM and Mitochondrial Diseases
Nervous System Diseases Antibodies	>88 publications with TFAM and Nervous System Diseases
Disease Models, Animal Antibodies	>55 publications with TFAM and Disease Models, Animal
Cardiovascular Diseases Antibodies	>50 publications with TFAM and Cardiovascular Diseases
Insulin Resistance Antibodies	>41 publications with TFAM and Insulin Resistance
Heart Diseases Antibodies	>36 publications with TFAM and Heart Diseases
Inflammation Antibodies	>34 publications with TFAM and Inflammation
Necrosis Antibodies	>27 publications with TFAM and Necrosis
Liver Diseases Antibodies	>20 publications with TFAM and Liver Diseases
Hyperglycemia Antibodies	>17 publications with TFAM and Hyperglycemia

Organs/Tissues associated with TFAM recombinant protein

Organ/Tissue Name	Pubmed Publications
Muscle Antibodies	>207 publications with TFAM and Muscle
Heart Antibodies	>89 publications with TFAM and Heart
Brain Antibodies	>80 publications with TFAM and Brain
Blood Antibodies	>79 publications with TFAM and Blood
Liver Antibodies	>76 publications with TFAM and Liver
Connective Tissue Antibodies	>31 publications with TFAM and Connective Tissue
Vascular Antibodies	>22 publications with TFAM and Vascular
Lung Antibodies	>18 publications with TFAM and Lung
Kidney Antibodies	>16 publications with TFAM and Kidney
Thyroid Antibodies	>15 publications with TFAM and Thyroid