Human CTDSPL Recombinant Protein – Cat# MBS144605

CTD Small Phosphatase-Like (CTDSPL) Human Recombinant Protein

Name: CTDSPL Recombinant Protein; CTD Small Phosphatase-Like; Human; MyBioSource
Brand: MyBioSource
SKU: MBS144605
Price: 250 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS144605

Description: CTDSPL Human Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 209 amino acids (82-265) and having a molecular mass of 23.9kDa.CTDSPL is fused to a 24 amino acid His-tag at N-terminus & purified by… More details

$250 / 0.005 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

CTD Small Phosphatase-Like (CTDSPL), Recombinant Protein

Full Product Name

Recombinant Human CTD Small Phosphatase-Like

Product Gene Name

CTDSPL recombinant protein

Product Synonym Names

CTDSPL Human; CTD Small Phosphatase-Like Human Recombinant; CTD small phosphatase-like protein; CTDSP-like; Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 3; NIF-like protein; Nuclear LIM interactor-interacting factor 1; NLI-interacting factor 1; Protein YA22; hYA22; RBSP3; Small C-terminal domain phosphatase 3; SCP3; Small CTD phosphatase 3; CTDSPL; C3orf8; NIF1; NIFL; SCP3; YA22; PSR1

Sequence

MGSSHHH HHH SSGLVPRGSH MGSHMK YLLP EVTVLDYGKK CVVIDLDETL VHSSFKPISN ADFIVPVEID GTIHQVYVLK RPHVDEFLQR MGQLFECVLF TASLAKYADP VADLLDRWGV FRARLFRESC VFHRGNYVKD LSRLGRELSK VIIVDNSPAS YIFHPENAVP VQSWFDDMTD TELLDLIPFF EGLSREDDVY SMLHRLCNR.

Host

E Coli

Form/Format

The CTDSPL solution (0.5mg/ml) contains 20mM Tris-HCl buffer (pH8.0), 40% glycerol, 0.15M NaCl and 1mM DTT.
Sterile filtered colorless solution.

Purity/Purification

Greater than 90.0% as determined by SDS-PAGE.

Preparation and Storage

Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.

Molecular Weight

29,937 Da

OMIM

608592

3D Structure

ModBase 3D Structure for O15194

Product Categories/Family for CTDSPL recombinant protein

Enzymes; Phosphatase

Other Notes

Small volumes of CTDSPL recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CTDSPL purchase

MBS144605 is a recombinant protein targeting CTDSPL. Also known as Recombinant Human CTD Small Phosphatase-Like. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for CTDSPL. It may not necessarily be applicable to this product.

NCBI GI #

56549683

NCBI GeneID

10217

NCBI Accession #

NP_001008393.1

UniProt Primary Accession #

O15194

UniProt Secondary Accession #

Q3ZTU0; Q70KI4; Q7Z5Q2

UniProt Related Accession #

O15194

GenBank Nucleotide #

NM_001008392.1

NCBI Official Full Name

CTD small phosphatase-like protein isoform 1

NCBI Official Synonym Full Names

CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like

NCBI Official Symbol

CTDSPL

NCBI Official Synonym Symbols

PSR1; SCP3; HYA22; RBSP3; C3orf8

UniProt Protein Name

CTD small phosphatase-like protein

UniProt Synonym Protein Names

Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 3; NIF-like protein; Nuclear LIM interactor-interacting factor 1; NLI-interacting factor 1; Protein YA22; hYA22; RBSP3; Small C-terminal domain phosphatase 3; SCP3; Small CTD phosphatase 3

Protein Family

CTD small phosphatase-like protein

UniProt Gene Name

CTDSPL

UniProt Synonym Gene Names

C3orf8; NIF1; NIFL; SCP3; YA22; CTDSP-like; NLI-interacting factor 1; hYA22; SCP3; Small CTD phosphatase 3

UniProt Entry Name

CTDSL_HUMAN

NCBI Protein Information

CTD small phosphatase-like protein; CTDSP-like; NIF-like protein; NLI-interacting factor 1; RB protein serine phosphatase from chromosome 3; carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 3; nuclear LIM interactor-interacting factor 1; small C-terminal domain phosphatase 3; small CTD phosphatase 3

UniProt Comments for CTDSPL

CTDSPL: Preferentially catalyzes the dephosphorylation of 'Ser- 5' within the tandem 7 residues repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.1.3.16; Phosphatase

Chromosomal Location of Human Ortholog: 3p21.3

Cellular Component: nucleus

Molecular Function: metal ion binding; phosphoprotein phosphatase activity

Biological Process: negative regulation of protein amino acid phosphorylation; dephosphorylation

Research Articles on CTDSPL

1. identified RBSP3, a phosphatase-like tumor suppressor, as a bona fide target of miR-100 and validated that RBSP3 was involved in cell differentiation and survival in acute myeloid leukemia

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with CTDSPL recombinant protein

Reference Product	PubMed Publications
ITGA9 recombinant protein	>7 publications with CTDSPL and ITGA9
NPRL2 recombinant protein	>2 publications with CTDSPL and NPRL2
SMAD2 recombinant protein	>1 publications with CTDSPL and SMAD2

Pathways associated with CTDSPL recombinant protein

Products by Pathway	Pathway Diagram
BMP Receptor Signaling Pathway antibodies	BMP Receptor Signaling Pathway Diagram
Regulation Of Cytoplasmic And Nuclear SMAD2/3 Signaling Pathway antibodies	Regulation Of Cytoplasmic And Nuclear SMAD2/3 Signaling Pathway Diagram

Diseases associated with CTDSPL recombinant protein

Disease Name	Pubmed Publications
Adenocarcinoma Antibodies	>3 publications with CTDSPL and Adenocarcinoma
Precancerous Conditions Antibodies	>3 publications with CTDSPL and Precancerous Conditions
Anemia, Hemolytic Antibodies	>1 publications with CTDSPL and Anemia, Hemolytic
Infertility, Female Antibodies	>1 publications with CTDSPL and Infertility, Female
Infertility, Male Antibodies	>1 publications with CTDSPL and Infertility, Male
Kidney Diseases Antibodies	>1 publications with CTDSPL and Kidney Diseases
Liver Neoplasms Antibodies	>1 publications with CTDSPL and Liver Neoplasms
Hyperplasia Antibodies	>1 publications with CTDSPL and Hyperplasia
Carcinoma, Hepatocellular Antibodies	>1 publications with CTDSPL and Carcinoma, Hepatocellular
Prostatic Neoplasms Antibodies	>1 publications with CTDSPL and Prostatic Neoplasms

Organs/Tissues associated with CTDSPL recombinant protein

Organ/Tissue Name	Pubmed Publications
Lung Antibodies	>7 publications with CTDSPL and Lung
Bone Antibodies	>4 publications with CTDSPL and Bone
Lymph Node Antibodies	>4 publications with CTDSPL and Lymph Node
Bone Marrow Antibodies	>3 publications with CTDSPL and Bone Marrow
Blood Antibodies	>3 publications with CTDSPL and Blood
Prostate Antibodies	>2 publications with CTDSPL and Prostate
Spleen Antibodies	>1 publications with CTDSPL and Spleen
Liver Antibodies	>1 publications with CTDSPL and Liver
Embryonic Tissue Antibodies	>1 publications with CTDSPL and Embryonic Tissue
Kidney Antibodies	>1 publications with CTDSPL and Kidney