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Serine Racemase (SRR) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS144622

Description: SRR Human Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 364 amino acids (1-340) and having a molecular mass of 39.1kDa.SRR is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Serine Racemase (SRR), Recombinant Protein
Full Product Name
Recombinant Human Serine Racemase
Product Gene Name
SRR recombinant protein
Product Synonym Names
SRR Human; Serine Racemase Human Recombinant; Serine racemase; D-serine ammonia-lyase; D-serine dehydratase; L-serine ammonia-lyase; L-serine dehydratase; SRR; ILV1; ISO1
Sequence
MGSSHHH HHH SSGLVPRGSH MGSHMC AQYC ISFADVEKAH INIRDSIHLT PVLTSSILNQ LTGRNLFFKC ELFQKTGSFK IRGALNAVRS LVPDALERKP KAVVTHSSGN HGQALTYAAK LEGIPAYIVV PQTAPDCKKL AIQAYGASIV YCEPSDESRE NVAKRVTEET EGIMVHPNQE PAVIAGQGTI ALEVLNQVPL VDALVVPVGG GGMLAGIAIT VKALKPSVKV YAAEPSNADD CYQSKLKGKL MPNLYPPETI ADGVKSSIGL NTWPIIRDLV DDIFTVTEDE IKCATQLVWE RMKLLIEPTA GVGVAAVLSQ HFQTVSPEVK NICIVLSGGN VDLTSSITWV KQAERPASYQ SVSV.
Host
E Coli
Form/Format
The SRR solution (0.5mg/ml) contains 20mM Tris-HCl buffer (pH8.0), 20% glycerol, 0.1M NaCl and 1mM DTT.
Sterile Filtered colorless solution.
Purity/Purification
Greater than 85.0% as determined by SDS-PAGE.
Preparation and Storage
Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Molecular Weight
36,566 Da
OMIM
606477
3D Structure
ModBase 3D Structure for Q9GZT4

Product Categories/Family for SRR recombinant protein

Enzymes; Lyase

Other Notes

Small volumes of SRR recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SRR purchase

MBS144622 is a recombinant protein targeting SRR. Also known as Recombinant Human Serine Racemase. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for SRR. It may not necessarily be applicable to this product.

NCBI GI #
11345492
NCBI GeneID
63826
NCBI Accession #
NP_068766.1
UniProt Primary Accession #
Q9GZT4
UniProt Secondary Accession #
Q6IA55; D3DTI5
UniProt Related Accession #
Q9GZT4
GenBank Nucleotide #
NM_021947.2
NCBI Official Full Name
serine racemase isoform a
NCBI Official Synonym Full Names
serine racemase
NCBI Official Symbol
SRR
NCBI Official Synonym Symbols
ILV1; ISO1
UniProt Protein Name
Serine racemase
UniProt Synonym Protein Names
D-serine ammonia-lyase; D-serine dehydratase; L-serine ammonia-lyase; L-serine dehydratase
Protein Family
Probable serine racemase
UniProt Gene Name
SRR
UniProt Entry Name
SRR_HUMAN
NCBI Protein Information
serine racemase; D-serine ammonia-lyase; D-serine dehydratase; L-serine ammonia-lyase; L-serine dehydratase

UniProt Comments for SRR

SRR: Catalyzes the synthesis of D-serine from L-serine. D- serine is a key coagonist with glutamate at NMDA receptors. Has dehydratase activity towards both L-serine and D-serine. Belongs to the serine/threonine dehydratase family.

Protein type: EC 5.1.1.18; Isomerase; EC 4.3.1.18; Amino Acid Metabolism - glycine, serine and threonine; EC 4.3.1.17

Chromosomal Location of Human Ortholog: 17p13

Cellular Component: cell soma; apical part of cell; cytoplasm; plasma membrane

Molecular Function: protein homodimerization activity; glycine binding; threonine racemase activity; L-serine ammonia-lyase activity; magnesium ion binding; calcium ion binding; serine racemase activity; D-serine ammonia-lyase activity; ATP binding; PDZ domain binding; pyridoxal phosphate binding

Biological Process: response to drug; pyruvate biosynthetic process; L-serine metabolic process; response to morphine; response to lipopolysaccharide; brain development; serine family amino acid metabolic process; protein homotetramerization; aging
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Research Articles on SRR

1. cross-talk between allosteric and active sites, leading to the stabilization of two alternative protein conformations with ATP affinities of ~ 10 muM and 1.8 mm

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with SRR recombinant protein

 Reference Product  PubMed Publications
 SHMT1 recombinant protein  >3 publications with SRR and SHMT1
 SDS recombinant protein  >1 publications with SRR and SDS

Pathways associated with SRR recombinant protein

 Products by Pathway  Pathway Diagram
 Glycine, Serine And Threonine Metabolism Pathway antibodies  Glycine, Serine And Threonine Metabolism Pathway Diagram
 Glycine, Serine And Threonine Metabolism Pathway antibodies  Glycine, Serine And Threonine Metabolism Pathway Diagram
 Serine And Glycine Biosynthesis Pathway antibodies  Serine And Glycine Biosynthesis Pathway Diagram

Diseases associated with SRR recombinant protein

 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >40 publications with SRR and Cardiovascular Diseases
 Brain Diseases Antibodies  >20 publications with SRR and Brain Diseases
 Hypertension Antibodies  >15 publications with SRR and Hypertension
 Liver Diseases Antibodies  >14 publications with SRR and Liver Diseases
 Liver Neoplasms Antibodies  >13 publications with SRR and Liver Neoplasms
 Disease Models, Animal Antibodies  >13 publications with SRR and Disease Models, Animal
 Hepatitis Antibodies  >13 publications with SRR and Hepatitis
 Infertility, Male Antibodies  >8 publications with SRR and Infertility, Male
 Kidney Diseases Antibodies  >8 publications with SRR and Kidney Diseases
 Poisoning Antibodies  >5 publications with SRR and Poisoning

Organs/Tissues associated with SRR recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >84 publications with SRR and Blood
 Brain Antibodies  >51 publications with SRR and Brain
 Liver Antibodies  >42 publications with SRR and Liver
 Heart Antibodies  >39 publications with SRR and Heart
 Lung Antibodies  >38 publications with SRR and Lung
 Kidney Antibodies  >32 publications with SRR and Kidney
 Bone Antibodies  >30 publications with SRR and Bone
 Muscle Antibodies  >14 publications with SRR and Muscle
 Prostate Antibodies  >13 publications with SRR and Prostate
 Stomach Antibodies  >13 publications with SRR and Stomach
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