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3-Ketodihydrosphingosine Reductase (KDSR) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS144733

Description: KDSR Human Recombinant fused with a 21 amino acid His tag at N-terminus produced in E Coli is a single, non-glycosylated, polypeptide chain containing 266 amino acids (26-270 a.a.) and having a molecular mass of 29kDa. The KDSR is purified by… More details

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Product Overview

Online Datasheet in PDF
Product Name
3-Ketodihydrosphingosine Reductase (KDSR), Recombinant Protein
Full Product Name
Recombinant Human 3-Ketodihydrosphingosine Reductase
Product Gene Name
KDSR recombinant protein
Product Synonym Names
KDSR Human; 3-Ketodihydrosphingosine Reductase Human Recombinant; 3-ketodihydrosphingosine reductase; KDS reductase; 3-dehydrosphinganine reductase; Follicular variant translocation protein 1; FVT-1; KDSR; FVT1; DHSR; SDR35C1; FLJ36555; FLJ92680
Sequence
MGSSHHH HHH SSGLVPRGSH MKPLAL PGAH VVVTGGSSGI GKCIAIECYK QGAFITLVAR NEDKLLQAKK EIEMHSINDK QVVLCISVDV SQDYNQVENV IKQAQEKLGP VDMLVNCAGM AVSGKFEDLE VSTFERLMSI NYLGSVYPSR AVITTMKERR VGRIVFVSSQ AGQLGLFGFT AYSASKFAIR GLAEALQMEV KPYNVYITVA YPPDTDTPGF AEENRTKPLE TRLISETTSV CKPEQVAKQI VKDAIQGNFN SSLGSD
Host
E Coli
Form/Format
The KDSR solution (0.5 mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 1mM DTT, 10% glycerol, 0.1M NaCl and 0.1mM PMSF.
The KDSR is supplied as a sterile filtered colorless solution.
Purity/Purification
KDSR purity was found to be greater than 90.0% as determined by SDS-PAGE.
Molecular Weight
29,159 Da
OMIM
136440
3D Structure
ModBase 3D Structure for Q06136

Product Categories/Family for KDSR recombinant protein

Enzymes; Reductase

Other Notes

Small volumes of KDSR recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for KDSR purchase

MBS144733 is a recombinant protein targeting KDSR. Also known as Recombinant Human 3-Ketodihydrosphingosine Reductase. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for KDSR. It may not necessarily be applicable to this product.

NCBI GI #
4503817
NCBI GeneID
2531
NCBI Accession #
NP_002026.1
UniProt Primary Accession #
Q06136
UniProt Secondary Accession #
B2R5Y1; B4DMX0
UniProt Related Accession #
Q06136
GenBank Nucleotide #
NM_002035.2
NCBI Official Full Name
3-ketodihydrosphingosine reductase
NCBI Official Synonym Full Names
3-ketodihydrosphingosine reductase
NCBI Official Symbol
KDSR
NCBI Official Synonym Symbols
DHSR; FVT1; SDR35C1
UniProt Protein Name
3-ketodihydrosphingosine reductase
UniProt Synonym Protein Names
3-dehydrosphinganine reductase; Follicular variant translocation protein 1; FVT-1
Protein Family
3-ketodihydrosphingosine reductase
UniProt Gene Name
KDSR
UniProt Synonym Gene Names
FVT1; KDS reductase; FVT-1
UniProt Entry Name
KDSR_HUMAN
NCBI Protein Information
3-ketodihydrosphingosine reductase; 3-dehydrosphinganine reductase; FVT-1; KDS reductase; follicular lymphoma variant translocation 1; follicular variant translocation protein 1; short chain dehydrogenase/reductase family 35C, member 1

NCBI Summary for KDSR

The protein encoded by this gene catalyzes the reduction of 3-ketodihydrosphingosine to dihydrosphingosine. The putative active site residues of the encoded protein are found on the cytosolic side of the endoplasmic reticulum membrane. A chromosomal rearrangement involving this gene is a cause of follicular lymphoma, also known as type II chronic lymphatic leukemia. The mutation of a conserved residue in the bovine ortholog causes spinal muscular atrophy. [provided by RefSeq, Jul 2008]
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UniProt Comments for KDSR

FVT1: Catalyzes the reduction of 3-ketodihydrosphingosine (KDS) to dihydrosphingosine (DHS). A chromosomal aberration involving KDSR is a cause of follicular lymphoma; also known as type II chronic lymphatic leukemia. Translocation t(2;18)(p11;q21) with a Ig J kappa chain region. Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Protein type: Lipid Metabolism - sphingolipid; Oxidoreductase; Membrane protein, multi-pass; Oncoprotein; EC 1.1.1.102; Membrane protein, integral

Chromosomal Location of Human Ortholog: 18q21.3

Cellular Component: extracellular space; endoplasmic reticulum membrane; membrane; endoplasmic reticulum; integral to membrane

Molecular Function: 3-dehydrosphinganine reductase activity

Biological Process: sphingolipid metabolic process; sphingolipid biosynthetic process; 3-keto-sphinganine metabolic process
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Research Articles on KDSR

1. FVT1 is significantly underexpressed by germinal center-type diffuse large B-cell lymphoma compared with non-germinal center-type DLBCL, follicular lymphoma, & normal tonsil control samples. Increased expression of FVT1 correlated with decreased survival.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with KDSR recombinant protein

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