Human IL36G Active Protein – Cat# MBS144751

Interleukin-36 Gamma (IL36G) Human Active Protein

Name: IL36G Active Protein; Interleukin-36 Gamma; Human; MyBioSource
Brand: MyBioSource
SKU: MBS144751
Price: 250 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS144751

Description: IL36G (152 a.a.) Human Recombinant produced in E Coli is a single, non-glycosylated, polypeptide chain containing 152 amino acids and having a molecular mass of 17.0kDa.The IL36G (152 a.a.) is purified by proprietary chromatographic… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Interleukin-36 Gamma (IL36G), Active Protein

Full Product Name

Recombinant Human Interleukin-36 Gamma 152 a.a.

Product Gene Name

IL36G active protein

Product Synonym Names

IL36G 152 a.a. Human; Interleukin-36 Gamma (152 a.a) Human Recombinant; Interleukin 36 gamma; IL1F9; interleukin 1 family member 9; Interleukin-1 epsilon; IL-1RP2; IL-1H1; IL1E; interleukin 1-related protein 2; Interleukin-1 homolog 1; IL36G 152 a.a.

Sequence

SMCKPITGTI NDLNQQVWTL QGQNLVAVPR SDSVTPVTVA VITCKYPEAL EQGRGDPIYL GIQNPEMCLY CEKVGEQPTL QLKEQKIMDL YGQPEPVKPF LFYRAKTGRT STLESVAFPD WFIASSKRDQ PIILTSELGK SYNTAFELNI ND

Host

E Coli

Form/Format

Lyophilized from a 0.2 um filtered concentrated solution in 1xPBS, pH 7.4, containing 5% trehalose.
Sterile Filtered White lyophilized (freeze-dried) powder.

Purity/Purification

Greater than 95.0% as determined by SDS-PAGE.

Preparation and Storage

Lyophilized IL36g Human although stable at room temperature for 3 weeks, should be stored desiccated below -18 degree C. Upon reconstitution IL36g should be stored at 4 degree C between 2-7 days and for future use below -18 degree C.Please prevent freeze-thaw cycles.

Molecular Weight

14,928 Da

OMIM

605542

3D Structure

ModBase 3D Structure for Q9NZH8

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Solubility

It is recommended to reconstitute the lyophilized IL36g in sterile 18M-cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions.

Biological Activity

Fully biologically active when compared to standard. The ED50 as measured by its ability to induce IL-8 secretion in human preadipocytes is less than 15ng/ml, corresponding to a Specific Activity of 67,000 IU/mg.

Product Categories/Family for IL36G active protein

Cytokines and Growth Factors; Cytokines; Interleukin

Other Notes

Small volumes of IL36G active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for IL36G purchase

MBS144751 is an active protein targeting IL36G. Also known as Recombinant Human Interleukin-36 Gamma 152 a.a.. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for IL36G. It may not necessarily be applicable to this product.

NCBI GI #

514388113

NCBI GeneID

56300

NCBI Accession #

NP_001265497.1

UniProt Primary Accession #

Q9NZH8

UniProt Secondary Accession #

Q56B91; Q6UVX7; Q7RTZ9

UniProt Related Accession #

Q9NZH8

GenBank Nucleotide #

NM_001278568.1

NCBI Official Full Name

interleukin-36 gamma isoform 2

NCBI Official Synonym Full Names

interleukin 36, gamma

NCBI Official Symbol

IL36G

NCBI Official Synonym Symbols

IL1E; IL1F9; IL1H1; IL-1F9; IL-1H1; IL1RP2; IL-1RP2

UniProt Protein Name

Interleukin-36 gamma

UniProt Synonym Protein Names

IL-1-related protein 2; IL-1RP2; Interleukin-1 epsilon; IL-1 epsilon; Interleukin-1 family member 9; IL-1F9; Interleukin-1 homolog 1; IL-1H1

Protein Family

Interleukin

UniProt Gene Name

IL36G

UniProt Synonym Gene Names

IL1E; IL1F9; IL1H1; IL1RP2; IL-1RP2; IL-1 epsilon; IL-1F9; IL-1H1

UniProt Entry Name

IL36G_HUMAN

NCBI Protein Information

interleukin-36 gamma; IL-1 epsilon; IL-1 related protein 2; IL-1(EPSILON); IL-1-epsilon; IL-1-related protein 2; interleukin 1 family, member 9; interleukin 1-related protein 2; interleukin-1 epsilon; interleukin-1 family member 9; interleukin-1 homolog 1

NCBI Summary for IL36G

The protein encoded by this gene is a member of the interleukin 1 cytokine family. The activity of this cytokine is mediated by interleukin 1 receptor-like 2 (IL1RL2/IL1R-rp2), and is specifically inhibited by interleukin 1 family, member 5 (IL1F5/IL-1 delta). Interferon-gamma, tumor necrosis factor-alpha and interleukin 1, beta (IL1B) are reported to stimulate the expression of this cytokine in keratinocytes. The expression of this cytokine in keratinocytes can also be induced by a contact hypersensitivity reaction or herpes simplex virus infection. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2013]

UniProt Comments for IL36G

Il1f9: Function as an agonist of NF-kappa B activation through the orphan IL-1-receptor-related protein 2. Could constitute part of an independent signaling system analogous to interleukin-1 alpha (IL-1A), beta (IL-1B) receptor agonist and interleukin-1 receptor type I (IL-1R1), that is present in epithelial barriers and takes part in local inflammatory response. Belongs to the IL-1 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cytokine

Chromosomal Location of Human Ortholog: 2q12-q21

Cellular Component: extracellular space

Molecular Function: interleukin-1 receptor binding; cytokine activity

Biological Process: cell-cell signaling; cytokine and chemokine mediated signaling pathway; positive regulation of interleukin-6 production; innate immune response; negative regulation of myoblast differentiation; inflammatory response

Research Articles on IL36G

1. CAMP induces IL-36gamma expression leading to initiation of skin inflammation and occasional exacerbations of psoriasis.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with IL36G active protein

Disease Name	Pubmed Publications
Inflammation Antibodies	>6 publications with IL36G and Inflammation
Skin Diseases Antibodies	>4 publications with IL36G and Skin Diseases
Disease Models, Animal Antibodies	>1 publications with IL36G and Disease Models, Animal
Dermatitis, Atopic Antibodies	>1 publications with IL36G and Dermatitis, Atopic
Death Antibodies	>1 publications with IL36G and Death
Necrosis Antibodies	>1 publications with IL36G and Necrosis

Organs/Tissues associated with IL36G active protein

Organ/Tissue Name	Pubmed Publications
Lung Antibodies	>1 publications with IL36G and Lung