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CGRP Receptor Component (CRCP) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS144756

Description: CRCP Human Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 168 amino acids (1-148) and having a molecular mass of 19.0 kDa.The CRCP is fused to a 20 amino acid His-Tag at N-terminus and purified by… More details

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Testing Data View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
CGRP Receptor Component (CRCP), Recombinant Protein
Full Product Name
Recombinant Human CGRP Receptor Component
Product Gene Name
CRCP recombinant protein
Product Synonym Names
CRCP Human; CGRP Receptor Component Human Recombinant; CGRP receptor component protein; CGRP-RCP; RCP; RCP9; Calcitonin gene-related peptide-receptor component protein; RNA polymerase III subunit C9; DNA-directed RNA polymerase III subunit RPC9; HsC17; MGC111194
Sequence
MGSSHHH HHH SSGLVPRGSH MEVKDANSAL LSNYEVFQLL TDLKEQRKES GKNKHSSGQQ NLNTITYETL KYISKTPCRH QSPEIVREFL TALKSHKLTK AEKLQLLNHR PVTAVEIQLM VEESEERLTE EQIEALLHTV TSILPAEPEA EQKKNTNSNV AMDEEDPA
Host
E Coli
Form/Format
The CRCP solution (0.5mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.1M NaCl, 1mM DTT and 20% glycerol.
Sterile Filtered colorless solution.
Purity/Purification
Greater than 95% as determined by SDS-PAGE.
Molecular Weight
8,011 Da
OMIM
606121
3D Structure
ModBase 3D Structure for O75575

Product Categories/Family for CRCP recombinant protein

Recombinant & Natural Proteins; Recombinant Proteins

Other Notes

Small volumes of CRCP recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CRCP purchase

MBS144756 is a recombinant protein targeting CRCP. Also known as Recombinant Human CGRP Receptor Component. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for CRCP. It may not necessarily be applicable to this product.

NCBI GI #
100913026
NCBI GeneID
27297
NCBI Accession #
NP_001035737.1
UniProt Primary Accession #
O75575
UniProt Secondary Accession #
Q3KRA3; Q5HYF1; Q8IXL4; A8MUZ4; A8MW23; B2R4H4; B4E198
UniProt Related Accession #
O75575
GenBank Nucleotide #
NM_001040647.1
NCBI Official Full Name
DNA-directed RNA polymerase III subunit RPC9 isoform b
NCBI Official Synonym Full Names
CGRP receptor component
NCBI Official Symbol
CRCP
NCBI Official Synonym Symbols
RCP; RCP9; CGRPRCP; CGRP-RCP
UniProt Protein Name
DNA-directed RNA polymerase III subunit RPC9
UniProt Synonym Protein Names
Calcitonin gene-related peptide-receptor component protein; CGRP-RCP; CGRP-receptor component protein; CGRPRCP; HsC17
UniProt Gene Name
CRCP
UniProt Synonym Gene Names
RNA polymerase III subunit C9; CGRP-RCP; CGRP-receptor component protein; CGRPRCP; HsC17
UniProt Entry Name
RPC9_HUMAN
NCBI Protein Information
DNA-directed RNA polymerase III subunit RPC9; CGRP-receptor component protein; RNA polymerase III subunit C9; calcitonin gene-related peptide-receptor component protein

NCBI Summary for CRCP

This gene encodes a membrane protein that functions as part of a receptor complex for a small neuropeptide that increases intracellular cAMP levels. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

UniProt Comments for CRCP

CGRP-RCP: an ubiquitous coupling protein for the calcitonin gene-related peptide (CGRP) and adrenomedullin receptors. Modulates ligand responsiveness in a variety of tissues. Two splice-variant isoforms have been described.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 7q11.21

Cellular Component: nucleoplasm; DNA-directed RNA polymerase III complex; acrosome; plasma membrane; cytosol

Molecular Function: calcitonin gene-related polypeptide receptor activity; DNA-directed RNA polymerase activity; nucleotide binding

Biological Process: transcription from RNA polymerase III promoter; transcription initiation from RNA polymerase III promoter; termination of RNA polymerase III transcription; neuropeptide signaling pathway; positive regulation of interferon type I production; innate immune response; gene expression; defense response to virus; RNA elongation from RNA polymerase III promoter
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Research Articles on CRCP

1. In this review, the influence of the CGRP family peptides in reproduction and pregnancy is explored and discussed.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with CRCP recombinant protein

 Reference Product  PubMed Publications
 CALCRL recombinant protein  >6 publications with CRCP and CALCRL

Pathways associated with CRCP recombinant protein

 Products by Pathway  Pathway Diagram
 Cytosolic Sensors Of Pathogen-associated DNA Pathway antibodies  Cytosolic Sensors Of Pathogen-associated DNA Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Innate Immune System Pathway antibodies  Innate Immune System Pathway Diagram
 Myometrial Relaxation And Contraction Pathways antibodies  Myometrial Relaxation And Contraction Pathways Diagram
 RNA Polymerase I, RNA Polymerase III, And Mitochondrial Transcription Pathway antibodies  RNA Polymerase I, RNA Polymerase III, And Mitochondrial Transcription Pathway Diagram
 RNA Polymerase III Abortive And Retractive Initiation Pathway antibodies  RNA Polymerase III Abortive And Retractive Initiation Pathway Diagram
 RNA Polymerase III Chain Elongation Pathway antibodies  RNA Polymerase III Chain Elongation Pathway Diagram
 RNA Polymerase III Transcription Pathway antibodies  RNA Polymerase III Transcription Pathway Diagram
 RNA Polymerase III Transcription Initiation Pathway antibodies  RNA Polymerase III Transcription Initiation Pathway Diagram

Diseases associated with CRCP recombinant protein

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >30 publications with CRCP and Nervous System Diseases
 Cardiovascular Diseases Antibodies  >17 publications with CRCP and Cardiovascular Diseases
 Hypothermia Antibodies  >7 publications with CRCP and Hypothermia
 Inflammation Antibodies  >4 publications with CRCP and Inflammation
 Neurobehavioral Manifestations Antibodies  >3 publications with CRCP and Neurobehavioral Manifestations
 Coma Antibodies  >3 publications with CRCP and Coma
 Carcinoma Antibodies  >3 publications with CRCP and Carcinoma
 Hypertension Antibodies  >3 publications with CRCP and Hypertension
 Fetal Death Antibodies  >2 publications with CRCP and Fetal Death
 Weight Loss Antibodies  >2 publications with CRCP and Weight Loss

Organs/Tissues associated with CRCP recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >51 publications with CRCP and Blood
 Vascular Antibodies  >33 publications with CRCP and Vascular
 Brain Antibodies  >28 publications with CRCP and Brain
 Heart Antibodies  >17 publications with CRCP and Heart
 Muscle Antibodies  >16 publications with CRCP and Muscle
 Connective Tissue Antibodies  >7 publications with CRCP and Connective Tissue
 Prostate Antibodies  >4 publications with CRCP and Prostate
 Liver Antibodies  >4 publications with CRCP and Liver
 Uterus Antibodies  >3 publications with CRCP and Uterus
 Testis Antibodies  >3 publications with CRCP and Testis
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