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Activin-A (INHBA) Rat Active Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS144774

Description: Active form Activin-A Rat Recombinant produced in E Coli is a homodimeric, non-glycosylated, polypeptide chain containing 2 x 117 amino acids and having a molecular weight of 26.2kDa.The Active form Activin-A is purified by standard… More details

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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
Activin-A (Inhba), Active Protein
Full Product Name
Recombinant Rat Activin-A
Product Gene Name
Inhba active protein
Product Synonym Names
Activin-A Rat; Activin-A Rat Recombinant; Inhba; Inhibin beta A; FSH releasing protein; rActivin A
Sequence
MGLECDGKVN ICCKKQFFVS FKDIGWNDWI IAPSGYHANY CEGECPSHIA GTSGSSLSFH STVINHYRMR GHSPFANLKS CCVPTKLRPM SMLYYDDGQN IIKKDIQNMI VEECGCS
Host
E Coli
Form/Format
Rat Activin-A was lyophilized from a concentrated 1mg/ml protein solution containing 0.02% TFA.
Lyophilized freeze dried powder.
Purity/Purification
Greater than 95% as obsereved by SDS-PAGE.
Molecular Weight
47,406 Da
3D Structure
ModBase 3D Structure for P18331
Active Protein Note
Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.
Solubility
Rat INHBA protein should be reconstituted in distilled pyrogen free water to a concentration of 100ug /ml which can then be further diluted to other aqueous solutions.
Biological Activity
Biological activity is assessed by the ability to induce cytoxicity of MPC-11 cells and was found to be 1-1.5 ng/ml corresponding to a specific activity of 666,667-1,000,000 Units/mg.

Product Categories/Family for Inhba active protein

Cytokines and Growth Factors; Growth Factors; Activin

Other Notes

Small volumes of Inhba active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Inhba purchase

MBS144774 is an active protein targeting Inhba. Also known as Recombinant Rat Activin-A. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for Inhba. It may not necessarily be applicable to this product.

NCBI GI #
8393613
NCBI GeneID
29200
NCBI Accession #
NP_058824.1
UniProt Primary Accession #
P18331
UniProt Related Accession #
P18331
GenBank Nucleotide #
NM_017128.2
NCBI Official Full Name
inhibin beta A chain preproprotein
NCBI Official Synonym Full Names
inhibin beta-A
NCBI Official Symbol
Inhba
UniProt Protein Name
Inhibin beta A chain
UniProt Synonym Protein Names
Activin beta-A chain
Protein Family
Inhibin
UniProt Gene Name
Inhba
UniProt Entry Name
INHBA_RAT
NCBI Protein Information
inhibin beta A chain; activin A; activin beta-A chain

NCBI Summary for Inhba

subunit which can homodimerize or heterodimerize with Inhbb to regulate FSH secretion [RGD, Feb 2006]

UniProt Comments for Inhba

INHBA: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins. Belongs to the TGF-beta family.

Protein type: Secreted; Secreted, signal peptide

Cellular Component: extracellular space; extracellular region

Molecular Function: identical protein binding; growth factor activity; protein heterodimerization activity; hormone activity; peptide hormone binding; cytokine activity; transforming growth factor beta receptor binding; receptor binding

Biological Process: positive regulation of transcription, DNA-dependent; positive regulation of cellular protein metabolic process; activin receptor signaling pathway; mesodermal cell differentiation; palate development; negative regulation of cell cycle; regulation of apoptosis; odontogenesis; negative regulation of cell proliferation; hair follicle development; ovarian follicle development; cell cycle arrest; response to drug; hemoglobin biosynthetic process; regulation of follicle-stimulating hormone secretion; positive regulation of erythrocyte differentiation; male gonad development; progesterone secretion; regulation of transcription from RNA polymerase II promoter; mesoderm formation; regulation of MAPKKK cascade; hemopoietic progenitor cell differentiation; positive regulation of transcription from RNA polymerase II promoter; negative regulation of cell growth; cell development; growth; G1/S transition of mitotic cell cycle
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Research Articles on Inhba

1. These data suggest that activin A produced by interstitial fibroblasts acts as a potent profibrotic factor during renal fibrosis. Blockade of activin A action may be a novel approach for the prevention of renal fibrosis progression.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with Inhba active protein

 Reference Product  PubMed Publications
 Inhbb active protein  >23 publications with Inhba and Inhbb
 Inha active protein  >18 publications with Inhba and Inha
 Fst active protein  >11 publications with Inhba and Fst
 Tgfb2 active protein  >1 publications with Inhba and Tgfb2
 Cga active protein  >1 publications with Inhba and Cga
 Inhbe active protein  >1 publications with Inhba and Inhbe
 Inhbc active protein  >1 publications with Inhba and Inhbc
 Fshb active protein  >1 publications with Inhba and Fshb
 Acvr2b active protein  >1 publications with Inhba and Acvr2b

Pathways associated with Inhba active protein

 Products by Pathway  Pathway Diagram
 Activin Signaling Pathway antibodies  Activin Signaling Pathway Diagram
 Activin Signaling Pathway antibodies  Activin Signaling Pathway Diagram
 Antagonism Of Activin By Follistatin Pathway antibodies  Antagonism Of Activin By Follistatin Pathway Diagram
 Glycoprotein Hormones Pathway antibodies  Glycoprotein Hormones Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 Peptide Hormone Biosynthesis Pathway antibodies  Peptide Hormone Biosynthesis Pathway Diagram
 Peptide Hormone Metabolism Pathway antibodies  Peptide Hormone Metabolism Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By Activin Pathway antibodies  Signaling By Activin Pathway Diagram
 Signaling Pathways Regulating Pluripotency Of Stem Cells antibodies  Signaling Pathways Regulating Pluripotency Of Stem Cells Diagram

Diseases associated with Inhba active protein

 Disease Name  Pubmed Publications
 Adenocarcinoma Antibodies  >8 publications with Inhba and Adenocarcinoma
 Necrosis Antibodies  >7 publications with Inhba and Necrosis
 Disease Models, Animal Antibodies  >6 publications with Inhba and Disease Models, Animal
 Kidney Diseases Antibodies  >5 publications with Inhba and Kidney Diseases
 Inflammation Antibodies  >5 publications with Inhba and Inflammation
 Lung Neoplasms Antibodies  >3 publications with Inhba and Lung Neoplasms
 Pre-Eclampsia Antibodies  >3 publications with Inhba and Pre-Eclampsia
 Cardiovascular Diseases Antibodies  >2 publications with Inhba and Cardiovascular Diseases
 Hypertrophy Antibodies  >2 publications with Inhba and Hypertrophy
 Infertility, Male Antibodies  >2 publications with Inhba and Infertility, Male

Organs/Tissues associated with Inhba active protein

 Organ/Tissue Name  Pubmed Publications
 Connective Tissue Antibodies  >2 publications with Inhba and Connective Tissue
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