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GRO-Gamma (rGRO g/CINC-2a) Rat Active Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS144808

Description: GRO-g Rat Recombinant produced in E Coli is a single,non-glycosylated, polypeptide chain containing 69 amino acids and having a molecular mass of 7.8kDa. The CXCL3 is purified by proprietary chromatographic techniques.Introduction: Chemokine… More details

$250 / 0.002 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
GRO-gamma (rGRO g/CINC-2a), Active Protein
Full Product Name
Recombinant Rat GRO-gamma (CXCL3), CINC-2 alpha
Product Gene Name
rGRO g/CINC-2a active protein
Product Synonym Names
GRO g/CINC-2a Rat; GRO-Gamma Rat Recombinant (CXCL3), CINC-2 alpha; Cytokine-induced neutrophil chemoattractant 2; CINC2; CINC-2; Macrophage inflammatory protein 2-alpha
Sequence
RELRCQCLKT LPRVDFENIQ SLTVTPPGPH CTQTEVIATL KDGQEVCLNP QAPRLQKIIQ KLLKSDKSS
Host
E Coli
Form/Format
The Rat CXCL3 lyophilized from a 0.2 um filtered concentrated solution in 1xPBS, pH 7.4.
Sterile Filtered White lyophilized (freeze-dried) powder.
Purity/Purification
Greater than 98.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
Molecular Weight
10,989 Da
3D Structure
ModBase 3D Structure for Q10746
Active Protein Note
Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.
Solubility
It is recommended to reconstitute the lyophilized GRO-gamma in sterile 18Mcm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions.
Biological Activity
Determined by its ability to chemoattract 293 transfected CXCR2 cells using a concentration range of 10-100 ng/ml, corresponding to a specific activity of 10,000-100,000 units/mg.

Product Categories/Family for rGRO g/CINC-2a active protein

Chemokines; GRO

Other Notes

Small volumes of rGRO g/CINC-2a active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for rGRO g/CINC-2a purchase

MBS144808 is an active protein targeting rGRO g/CINC-2a. Also known as Recombinant Rat GRO-gamma (CXCL3), CINC-2 alpha. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for rGRO g/CINC-2a. It may not necessarily be applicable to this product.

NCBI GI #
19924051
NCBI GeneID
171551
NCBI Accession #
NP_612531.1
UniProt Primary Accession #
Q10746
UniProt Secondary Accession #
Q10747; Q5CZ55; Q9EP62
UniProt Related Accession #
Q10746
GenBank Nucleotide #
NM_138522.1
NCBI Official Full Name
C-X-C motif chemokine 3
NCBI Official Synonym Full Names
chemokine (C-X-C motif) ligand 3
NCBI Official Symbol
Cxcl3
NCBI Official Synonym Symbols
Cinc2; Cinc-2; Gm1960
UniProt Protein Name
C-X-C motif chemokine 3
UniProt Synonym Protein Names
Cytokine-induced neutrophil chemoattractant 2; CINC-2; Macrophage inflammatory protein 2-alpha/beta; MIP2-alpha/beta
Protein Family
Growth-regulated protein
UniProt Gene Name
Cxcl3
UniProt Synonym Gene Names
Cinc2; CINC-2; MIP2-alpha/beta
UniProt Entry Name
CXCL3_RAT
NCBI Protein Information
C-X-C motif chemokine 3; MIP2-alpha/beta; cytokine-induced neutrophil chemoattractant 2; cytokine-induced neutrophil chemoattractant-2; macrophage inflammatory protein 2-alpha/beta

NCBI Summary for rGRO g/CINC-2a

acts as a chemoattractant for neutrophils; involved in the inflammatory response [RGD, Feb 2006]

UniProt Comments for rGRO g/CINC-2a

CXCL1: Has chemotactic activity for neutrophils. May play a role in inflammation and exerts its effects on endothelial cells in an autocrine fashion. In vitro, the processed forms GRO- alpha(4-73), GRO-alpha(5-73) and GRO-alpha(6-73) show a 30-fold higher chemotactic activity. Belongs to the intercrine alpha (chemokine CxC) family.

Protein type: Secreted; Motility/polarity/chemotaxis; Secreted, signal peptide

Cellular Component: extracellular space; extracellular region

Molecular Function: chemokine activity; CXCR chemokine receptor binding

Biological Process: G-protein coupled receptor protein signaling pathway; neutrophil chemotaxis; elevation of cytosolic calcium ion concentration; positive regulation of leukocyte chemotaxis; immune response; hemopoiesis; response to lipopolysaccharide; inflammatory response; chemotaxis; regulation of cell proliferation
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Research Articles on rGRO g/CINC-2a

1. The decreased serum concentration of CINC-1 as neuroprotective agent and increased CINC-2alpha in late stage of Morris hepatoma may be considered for their contribution to cerebellar degeneration.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with rGRO g/CINC-2a active protein

 Products by Pathway  Pathway Diagram
 Chemokine Receptors Bind Chemokines Pathway antibodies  Chemokine Receptors Bind Chemokines Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Cytokines And Inflammatory Response (BioCarta) Pathway antibodies  Cytokines And Inflammatory Response (BioCarta) Pathway Diagram
 Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway antibodies  Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 G Alpha (i) Signalling Events Pathway antibodies  G Alpha (i) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram

Diseases associated with rGRO g/CINC-2a active protein

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >73 publications with rGRO g/CINC-2a and Inflammation
 Necrosis Antibodies  >35 publications with rGRO g/CINC-2a and Necrosis
 Respiratory Tract Diseases Antibodies  >13 publications with rGRO g/CINC-2a and Respiratory Tract Diseases
 Lung Diseases Antibodies  >13 publications with rGRO g/CINC-2a and Lung Diseases
 Immune System Diseases Antibodies  >11 publications with rGRO g/CINC-2a and Immune System Diseases
 Skin Diseases Antibodies  >9 publications with rGRO g/CINC-2a and Skin Diseases
 Disease Models, Animal Antibodies  >7 publications with rGRO g/CINC-2a and Disease Models, Animal
 Death Antibodies  >7 publications with rGRO g/CINC-2a and Death
 Fibrosis Antibodies  >6 publications with rGRO g/CINC-2a and Fibrosis
 Neoplasms, Experimental Antibodies  >4 publications with rGRO g/CINC-2a and Neoplasms, Experimental

Organs/Tissues associated with rGRO g/CINC-2a active protein

 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >18 publications with rGRO g/CINC-2a and Lung
 Connective Tissue Antibodies  >5 publications with rGRO g/CINC-2a and Connective Tissue
 Eye Antibodies  >4 publications with rGRO g/CINC-2a and Eye
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