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Homeobox Protein DLX-1 (DLX1) Mouse Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1448212

This gene encodes a member of a homeobox transcription factor gene family similiar to the Drosophila distal-less gene. The encoded protein is localized to the nucleus where it may function as a transcriptional regulator of signals from multiple TGF-{beta}… More details

$935 / 0.02 mg (E-Coli) +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Homeobox protein DLX-1 (Dlx1), Recombinant Protein
Full Product Name
Recombinant Mouse Homeobox protein DLX-1 (Dlx1)
Product Gene Name
Dlx1 recombinant protein
Product Synonym Gene Name
Dlx1
Sequence
MTMTTMPESL NSPVSGKAVF MEFGPPNQQM SPSPMSHGHY SMHCLHSAGH SQPDGAYSSA SSFSRPLGYP YVNSVSSHAS SPYISSVQSY PGSASLAQSR LEDPGADSEK STVVEGGEVR FNGKGKKIRK PRTIYSSLQL QALNRRFQQT QYLALPERAE LAASLGLTQT QVKIWFQNKR SKFKKLMKQG GAALEGSALA NGRALSAGSP PVPPGWNPNS SSGKGSGSSA GSYVPSYTSW YPSAHQEAMQ QPQLM
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
27,309 Da
Sequence Positions
1-255, full length protein
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
3D Structure
ModBase 3D Structure for Q64317
Species
Mouse
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of Dlx1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Dlx1 purchase

MBS1448212 is a recombinant protein targeting Dlx1. Also known as Recombinant Mouse Homeobox protein DLX-1 (Dlx1). Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for Dlx1. It may not necessarily be applicable to this product.

NCBI GI #
6753644
NCBI GeneID
13390
NCBI Accession #
NP_034183.1
UniProt Primary Accession #
Q64317
UniProt Related Accession #
Q64317
GenBank Nucleotide #
NM_010053.2
NCBI Official Full Name
homeobox protein DLX-1
NCBI Official Synonym Full Names
distal-less homeobox 1
NCBI Official Symbol
Dlx1
NCBI Official Synonym Symbols
Dlx; Dlx-1
UniProt Protein Name
Homeobox protein DLX-1
Protein Family
Homeobox protein
UniProt Gene Name
Dlx1
NCBI Protein Information
homeobox protein DLX-1

NCBI Summary for Dlx1

The protein encoded by this gene is a homeobox-containing transcription factor involved in development. The encoded protein plays a role in craniofacial patterning, as well as in bone, placenta, and sensory organ formation. [provided by RefSeq, Aug 2015]

UniProt Comments for Dlx1

Plays a role as a transcriptional activator or repressor (PubMed:21875655). Inhibits several cytokine signaling pathways, such as TGFB1, activin-A/INHBA and BMP4 by interfering with the transcriptional stimulatory activity of transcription factors, such as MSX2, FAST2, SMAD2 and SMAD3 during hematopoietic cell differentiation (). Plays a role in terminal differentiation of interneurons, such as amacrine and bipolar cells in the developing retina (PubMed:21875655). Likely to play a regulatory role in the development of the ventral forebrain (PubMed:1676488). May play a role in craniofacial patterning and morphogenesis and may be involved in the early development of diencephalic subdivisions (PubMed:1676488).
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Research Articles on Dlx1

1. GABA is the major inhibitory neurotransmitter in the brain. We show that Dlx1/Dlx2 homeobox genes regulate GABA synthesis during forebrain development through direct activation of glutamic acid decarboxylase enzyme isoforms that convert glutamate to GABA.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with Dlx1 recombinant protein

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >6 publications with Dlx1 and Neoplasms
 Child Development Disorders, Pervasive Antibodies  >4 publications with Dlx1 and Child Development Disorders, Pervasive
 Eye Abnormalities Antibodies  >3 publications with Dlx1 and Eye Abnormalities
 Autistic Disorder Antibodies  >3 publications with Dlx1 and Autistic Disorder
 Craniofacial Abnormalities Antibodies  >3 publications with Dlx1 and Craniofacial Abnormalities
 Cleft Palate Antibodies  >2 publications with Dlx1 and Cleft Palate
 Nervous System Malformations Antibodies  >2 publications with Dlx1 and Nervous System Malformations
 Leukemia, Myeloid Antibodies  >2 publications with Dlx1 and Leukemia, Myeloid
 Embryo Loss Antibodies  >2 publications with Dlx1 and Embryo Loss
 Abnormalities, Drug-Induced Antibodies  >1 publications with Dlx1 and Abnormalities, Drug-Induced

Organs/Tissues associated with Dlx1 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >68 publications with Dlx1 and Brain
 Embryonic Tissue Antibodies  >20 publications with Dlx1 and Embryonic Tissue
 Eye Antibodies  >14 publications with Dlx1 and Eye
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