Human ZNRF3 Active Protein – Cat# MBS1448216

E3 Ubiquitin-Protein Ligase ZNRF3 (ZNRF3) Human Active Protein

Name: ZNRF3 Active Protein; E3 Ubiquitin-Protein Ligase ZNRF3; Human; MyBioSource
Brand: MyBioSource
SKU: MBS1448216
Price: 350 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1448216

E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination and subsequent degradation of Wnt receptor complex components Frizzled and LRP6. Acts on both canonical and non-canonical Wnt signaling… More details

$350 / 0.02 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

E3 ubiquitin-protein ligase ZNRF3, Active Protein

Full Product Name

Recombinant Human E3 ubiquitin-protein ligase ZNRF3

Product Gene Name

ZNRF3 active protein

Product Synonym Names

RING finger protein 203; Zinc/RING finger protein 3

Sequence

KETAFVEVVL FESSPSGDYT TYTTGLTGRF SRAGATLSAE GEIVQMHPLG LCNNNDEEDL YEYGWVGVVK LEQPELDPKP CLTVLGKAKR AVQRGATAVI FDVSENPEAI DQLNQGSEDP LKRPVVYVKG ADAIKLMNIV NKQKVARARI QHRPPRQPTE YFDM

Host

Mammalian Cell

Form/Format

Lyophilized or liquid (Format to be determined during the manufacturing process)

Purity/Purification

Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)

Preparation and Storage

Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.

Molecular Weight

34.2 kDa

Sequence Positions

56-219aa; Extracellular Domain

OMIM

612062

3D Structure

ModBase 3D Structure for Q9ULT6

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Species

Homo sapiens (Human)

Product Categories/Family for ZNRF3 active protein

Epigenetics and Nuclear Signaling

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Product References and Citations for ZNRF3 active protein

"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. Sugano S. Nat. Genet. 36:40-45(2004)

Other Notes

Small volumes of ZNRF3 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ZNRF3 purchase

MBS1448216 is an active protein targeting ZNRF3. Also known as Recombinant Human E3 ubiquitin-protein ligase ZNRF3. Host: Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for ZNRF3. It may not necessarily be applicable to this product.

NCBI GI #

332801080

NCBI GeneID

84133

NCBI Accession #

NP_001193927.1

UniProt Primary Accession #

Q9ULT6

UniProt Secondary Accession #

Q6ICH1; Q6NTF8; Q8WU18; B3KU18

UniProt Related Accession #

Q9ULT6

GenBank Nucleotide #

NM_001206998.1

NCBI Official Full Name

E3 ubiquitin-protein ligase ZNRF3 isoform 1

NCBI Official Synonym Full Names

zinc and ring finger 3

NCBI Official Symbol

ZNRF3

NCBI Official Synonym Symbols

RNF203; BK747E2.3

UniProt Protein Name

E3 ubiquitin-protein ligase ZNRF3

UniProt Synonym Protein Names

RING finger protein 203; Zinc/RING finger protein 3

Protein Family

E3 ubiquitin-protein ligase

UniProt Gene Name

ZNRF3

UniProt Synonym Gene Names

KIAA1133; RNF203

UniProt Entry Name

ZNRF3_HUMAN

NCBI Protein Information

E3 ubiquitin-protein ligase ZNRF3

UniProt Comments for ZNRF3

ZNRF3: E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination and subsequent degradation of Wnt receptor complex components Frizzled and LRP6. Acts on both canonical and non- canonical Wnt signaling pathway. Acts as a tumor suppressor in the intestinal stem cell zone by inhibiting the Wnt signaling pathway, thereby resticting the size of the intestinal stem cell zone. Belongs to the ZNRF3 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 6.3.2.19; Ubiquitin conjugating system; Membrane protein, integral; Ubiquitin ligase; EC 6.3.2.-

Chromosomal Location of Human Ortholog: 22q12.1

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: frizzled binding; ligase activity; protein binding; ubiquitin-protein ligase activity; zinc ion binding

Biological Process: protein ubiquitination; ubiquitin-dependent protein catabolic process; Wnt receptor signaling pathway through beta-catenin; Wnt receptor signaling pathway, planar cell polarity pathway

Research Articles on ZNRF3

1. Data indicate Dishevelled (DVL) as a dual function adaptor to recruit negative regulators ZNRF3/RNF43 to Wnt receptors to ensure proper control of pathway activity.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with ZNRF3 active protein

Reference Product	PubMed Publications
LGR4 active protein	>12 publications with ZNRF3 and LGR4
RSPO1 active protein	>11 publications with ZNRF3 and RSPO1
LGR5 active protein	>9 publications with ZNRF3 and LGR5
LRP6 active protein	>6 publications with ZNRF3 and LRP6
RSPO2 active protein	>6 publications with ZNRF3 and RSPO2
RSPO3 active protein	>5 publications with ZNRF3 and RSPO3
RSPO4 active protein	>3 publications with ZNRF3 and RSPO4
LGR6 active protein	>2 publications with ZNRF3 and LGR6
WNT3A active protein	>1 publications with ZNRF3 and WNT3A

Pathways associated with ZNRF3 active protein

Products by Pathway	Pathway Diagram
Regulation Of FZD By Ubiquitination Pathway antibodies	Regulation Of FZD By Ubiquitination Pathway Diagram
Signal Transduction Pathway antibodies	Signal Transduction Pathway Diagram
Signaling By Wnt Pathway antibodies	Signaling By Wnt Pathway Diagram
TCF Dependent Signaling In Response To WNT Pathway antibodies	TCF Dependent Signaling In Response To WNT Pathway Diagram

Diseases associated with ZNRF3 active protein

Disease Name	Pubmed Publications
Adenocarcinoma Antibodies	>5 publications with ZNRF3 and Adenocarcinoma
Neoplasms, Experimental Antibodies	>3 publications with ZNRF3 and Neoplasms, Experimental
Adrenocortical Carcinoma Antibodies	>3 publications with ZNRF3 and Adrenocortical Carcinoma
Hyperplasia Antibodies	>2 publications with ZNRF3 and Hyperplasia
Liver Neoplasms Antibodies	>2 publications with ZNRF3 and Liver Neoplasms
Liver Diseases Antibodies	>2 publications with ZNRF3 and Liver Diseases
Pancreatic Neoplasms Antibodies	>2 publications with ZNRF3 and Pancreatic Neoplasms
Chromosome Aberrations Antibodies	>1 publications with ZNRF3 and Chromosome Aberrations
Neoplasm Metastasis Antibodies	>1 publications with ZNRF3 and Neoplasm Metastasis
Kidney Diseases Antibodies	>1 publications with ZNRF3 and Kidney Diseases

Organs/Tissues associated with ZNRF3 active protein

Organ/Tissue Name	Pubmed Publications
Kidney Antibodies	>1 publications with ZNRF3 and Kidney