Mouse mKGF 2 Active Protein – Cat# MBS144840

Keratinocyte Growth Factor-2 (mKGF 2) Mouse Active Protein

Name: mKGF 2 Active Protein; Keratinocyte Growth Factor-2; Mouse; MyBioSource
Brand: MyBioSource
SKU: MBS144840
Price: 250 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS144840

Description: KGF 2 Mouse Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 173 amino acids and having a molecular mass of 19.5kDa. The KGF 2 is purified by proprietary chromatographic techniques.Introduction: KGF-2 is a… More details

$250 / 0.005 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Keratinocyte Growth Factor-2 (mKGF 2), Active Protein

Full Product Name

Recombinant Mouse Keratinocyte Growth Factor-2

Product Gene Name

mKGF 2 active protein

Product Synonym Names

KGF 2 Mouse; Keratinocyte Growth Factor-2 Mouse Recombinant; FGFA; FGF10; FGF-10; KGF-2; Fibroblast growth factor 10

Sequence

QALGQDMVSQ EATNCSSSSS SFSSPSSAGR HVRSYNHLQG DVRWRRLFSF TKYFLTIEKN GKVSGTKNED CPYSVLEITS VEIGVVAVKA INSNYYLAMN KKGKLYGSKE FNNDCKLKER IEENGYNTYA SFNWQHNGRQ MYVALNGKGA PRRGQKTRRK NTSAHFLPMT IQT

Host

E Coli

Form/Format

Lyophilized from a 0.2 um filtered concentrated solution in 1xPBS, pH 7.4 containing 5% trehalose.
Sterile Filtered White lyophilized (freeze-dried) powder.

Purity/Purification

Greater than 97.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.

Molecular Weight

23,597 Da

3D Structure

ModBase 3D Structure for O35565

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Solubility

It is recommended to reconstitute the lyophilized KGF 2 Mouse Recombinant in sterile 18M-cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions.

Biological Activity

Fully biologically active when compared to standard. The ED50 as determined by the dose-dependent stimulation of thymidine uptake by BaF3 cells expressing FGF receptors is <0.5ng/ml.

Product Categories/Family for mKGF 2 active protein

Cytokines and Growth Factors; Growth Factors; Keratinocyte Growth Factor

Other Notes

Small volumes of mKGF 2 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for mKGF 2 purchase

MBS144840 is an active protein targeting mKGF 2. Also known as Recombinant Mouse Keratinocyte Growth Factor-2. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for mKGF 2. It may not necessarily be applicable to this product.

NCBI GI #

7106313

NCBI GeneID

14165

NCBI Accession #

NP_032028.1

UniProt Primary Accession #

O35565

UniProt Secondary Accession #

Q543V5

UniProt Related Accession #

O35565

GenBank Nucleotide #

NM_008002.4

NCBI Official Full Name

fibroblast growth factor 10

NCBI Official Synonym Full Names

fibroblast growth factor 10

NCBI Official Symbol

Fgf10

NCBI Official Synonym Symbols

AEY17; Fgf-10; BB213776; Gsfaey17

UniProt Protein Name

Fibroblast growth factor 10

UniProt Synonym Protein Names

Keratinocyte growth factor 2

UniProt Gene Name

Fgf10

UniProt Synonym Gene Names

FGF-10

UniProt Entry Name

FGF10_MOUSE

NCBI Protein Information

fibroblast growth factor 10; keratinocyte growth factor 2

UniProt Comments for mKGF 2

FGF10: Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. May play a role in wound healing. Interacts with FGFR1 and FGFR2. Interacts with FGFBP1. Belongs to the heparin-binding growth factors family.

Protein type: Secreted; Cytokine; Secreted, signal peptide; Cell development/differentiation; Motility/polarity/chemotaxis

Cellular Component: extracellular matrix; extracellular space; cell surface; cell; extracellular region; plasma membrane; nucleus

Molecular Function: heparin binding; protein binding; growth factor activity; type 2 fibroblast growth factor receptor binding; fibroblast growth factor receptor binding; chemoattractant activity; receptor binding

Biological Process: salivary gland development; activation of MAPK activity; urothelial cell proliferation; somatic stem cell maintenance; positive regulation of transcription, DNA-dependent; muscle cell fate commitment; regulation of saliva secretion; embryonic pattern specification; G1/S-specific positive regulation of cyclin-dependent protein kinase activity; positive regulation of fibroblast proliferation; epithelial cell proliferation; cell-cell signaling; positive chemotaxis; embryonic digestive tract morphogenesis; induction of an organ; embryonic gut development; embryonic genitalia morphogenesis; spleen development; positive regulation of keratinocyte migration; inner ear morphogenesis; positive regulation of DNA repair; fibroblast growth factor receptor signaling pathway; semicircular canal morphogenesis; positive regulation of urothelial cell proliferation; organ growth; positive regulation of peptidyl-tyrosine phosphorylation; organ morphogenesis; branching morphogenesis of a tube; regulation of gene expression; blood vessel morphogenesis; smooth muscle cell differentiation; positive regulation of transcription from RNA polymerase II promoter; determination of left/right symmetry; alveolus development; positive regulation of epithelial cell proliferation; limb development; epidermis development; wound healing; radial glial cell differentiation; positive regulation of mitotic cell cycle; chemotaxis; regulation of epithelial cell proliferation; positive regulation of vascular endothelial growth factor receptor signaling pathway; induction of positive chemotaxis; negative regulation of cell proliferation; establishment of mitotic spindle orientation; epithelial cell differentiation; positive regulation of MAPKKK cascade; positive regulation of lymphocyte proliferation; epidermis morphogenesis; salivary gland morphogenesis; pancreas development; positive regulation of cell proliferation; male genitalia morphogenesis; thyroid gland development; lacrimal gland development; otic vesicle formation; positive regulation of Wnt receptor signaling pathway; female genitalia morphogenesis; positive regulation of Notch signaling pathway; organ formation; hair follicle morphogenesis; thymus development; keratinocyte proliferation; regulation of activin receptor signaling pathway; limb morphogenesis; embryonic camera-type eye development; odontogenesis of dentine-containing teeth; limb bud formation; negative regulation of cell differentiation; gut development; pituitary gland development; positive regulation of ATPase activity; actin cytoskeleton reorganization; white fat cell differentiation; blood vessel remodeling; positive regulation of Ras protein signal transduction; positive regulation of DNA replication; regulation of smoothened signaling pathway; lung development

Research Articles on mKGF 2

1. A signaling mechanism based on FGF10 and SHH directs outgrowth of the lung bud via a ligand-receptor-based Turing mechanism and a geometry effect in the embryonic mouse.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with mKGF 2 active protein

Products by Pathway	Pathway Diagram
Activated Point Mutants Of FGFR2 Pathway antibodies	Activated Point Mutants Of FGFR2 Pathway Diagram
Adaptive Immune System Pathway antibodies	Adaptive Immune System Pathway Diagram
Constitutive PI3K/AKT Signaling In Cancer Pathway antibodies	Constitutive PI3K/AKT Signaling In Cancer Pathway Diagram
DAP12 Interactions Pathway antibodies	DAP12 Interactions Pathway Diagram
DAP12 Signaling Pathway antibodies	DAP12 Signaling Pathway Diagram
Developmental Biology Pathway antibodies	Developmental Biology Pathway Diagram
Disease Pathway antibodies	Disease Pathway Diagram
Downstream Signal Transduction Pathway antibodies	Downstream Signal Transduction Pathway Diagram
Downstream Signaling Events Of B Cell Receptor (BCR) Pathway antibodies	Downstream Signaling Events Of B Cell Receptor (BCR) Pathway Diagram
Downstream Signaling Of Activated FGFR Pathway antibodies	Downstream Signaling Of Activated FGFR Pathway Diagram

Diseases associated with mKGF 2 active protein

Disease Name	Pubmed Publications
Disease Models, Animal Antibodies	>38 publications with mKGF 2 and Disease Models, Animal
Cleft Palate Antibodies	>29 publications with mKGF 2 and Cleft Palate
Lung Diseases Antibodies	>28 publications with mKGF 2 and Lung Diseases
Inflammation Antibodies	>21 publications with mKGF 2 and Inflammation
Cardiovascular Abnormalities Antibodies	>16 publications with mKGF 2 and Cardiovascular Abnormalities
Skin Diseases Antibodies	>14 publications with mKGF 2 and Skin Diseases
Prostatic Diseases Antibodies	>14 publications with mKGF 2 and Prostatic Diseases
Heart Defects, Congenital Antibodies	>13 publications with mKGF 2 and Heart Defects, Congenital
Lung Neoplasms Antibodies	>13 publications with mKGF 2 and Lung Neoplasms
Prostatic Neoplasms Antibodies	>13 publications with mKGF 2 and Prostatic Neoplasms

Organs/Tissues associated with mKGF 2 active protein

Organ/Tissue Name	Pubmed Publications
Embryonic Tissue Antibodies	>198 publications with mKGF 2 and Embryonic Tissue
Lung Antibodies	>174 publications with mKGF 2 and Lung
Brain Antibodies	>45 publications with mKGF 2 and Brain
Skin Antibodies	>43 publications with mKGF 2 and Skin
Pancreas Antibodies	>40 publications with mKGF 2 and Pancreas
Inner Ear Antibodies	>39 publications with mKGF 2 and Inner Ear
Eye Antibodies	>33 publications with mKGF 2 and Eye
Connective Tissue Antibodies	>23 publications with mKGF 2 and Connective Tissue
Stomach Antibodies	>22 publications with mKGF 2 and Stomach
Mammary Gland Antibodies	>12 publications with mKGF 2 and Mammary Gland